Clinical and Administrative Director, DC Partnership for HIV/AIDS Progress
810 7th Street, NE Room 2-140 Washington, DC 20002
Education and Training
2004 BS, Biology, BS, Psychology, Virginia Commonwealth University
2009 MD, Eastern Virginia Medical School
2009-2010 Internship, Internal Medicine, George Washington University
2010-2012 Residency, Internal Medicine, George Washington University
I am an academic clinician investigator, with a focus in viral hepatitis and HIV. During medical training and subsequent chief residency, I developed expertise in teaching and innovative program development, serving both my residency program and the surrounding community. As a clinician within the National Institute of Allergy and Infectious Disease, Laboratory of Immunoregulation clinic, I was immersed in clinical trials methodology, regulation, and oversight. I served as the evaluating provider for several research protocols, gaining experience in advanced HIV treatment and the novel use of directly-acting antiviral (DAA) therapy for hepatitis C.
In 2014 I transitioned to the Institute of Human Virology, where I now serve as Assistant Professor in the University of Maryland School of Medicine, and simultaneously lead the DC Partnership for HIV/AIDS Progress Viral Hepatitis Program as Clinical and Administrative Director. In this capacity, I have staffed multiple viral hepatitis clinics at the NIH and in District of Columbia community healthcare centers, to provide both research-related and standard clinical care in an urban cohort representative of the HCV epidemic. I served as the lead investigator of the SYNERGY study, investigating the limits of short duration combination DAA therapy and predictors of successful treatment, and the ASCEND study, a community-based HCV treatment investigation.
My current research focus is community and implementation-based improvements in the HIV and HCV care continuums, with an emphasis on marginalized populations.
Hepatitis C, HIV, Implementation Science
Kattakuzhy S, Levy R, Kottilil S. Sofosbuvir for treatment of chronic hepatitis C. Hepatol Int. 2015 Apr;9(2):161-73. doi: 10.1007/s12072-014-9606-9. Epub 2015 Jan 28. Review. PubMed PMID: 25788194.
Kohli A*, Kattakuzhy S*, Sidharthan S, Nelson A, McLaughlin M, Seamon C, Wilson E, Meissner EG, Sims Z, Silk R, Gross C, Akoth E, Tang L, Price A, Jolley TA, Emmanuel B, Proschan M, Teferi G, Chavez J, Abbott S, Osinusi A, Mo H, Polis MA, Masur H, Kottilil S. Four-Week Direct-Acting Antiviral Regimens in Noncirrhotic Patients With Hepatitis C Virus Genotype 1 Infection: An Open-Label, Nonrandomized Trial. Ann Intern Med. 2015 Dec 15;163(12):899-907. doi: 10.7326/M15-0642. Epub 2015 Nov 24. PubMed PMID: 26595450. *equal contribution
Kattakuzhy S, Wilson E, Sidharthan S, Sims Z, McLaughlin M, Price A, Silk R, Gross C, Akoth E, McManus M, Emmanuel B, Shrivastava S, Tang L, Nelson A, Teferi G, Chavez J, Lam B, Mo H, Osinusi A, Polis MA, Masur H, Kohli A, Kottilil S. Moderate Sustained Virologic Response Rates With 6-Week Combination Directly Acting Anti-Hepatitis C Virus Therapy in Patients With Advanced Liver Disease. Clin Infect Dis. 2016 Feb 15;62(4):440-447. PubMed PMID: 26503379; PubMed Central PMCID: PMC4725378
Kattakuzhy S, Levy R, Rosenthal E, Tang L, Wilson E, Kottilil S. Hepatitis C genotype 3 disease. Hepatol Int. 2016 Nov;10(6):861-870. Epub 2016 Jun 21. Review. PubMed PMID: 27328848.
Kattakuzhy S, Gross C, Emmanuel B, Teferi G, Jenkins V, Silk R, Akoth E, Thomas A, Ahmed C, Espinosa M, Price A, Rosenthal E, Tang L, Wilson E, Bentzen S, Masur H, Kottilil S; and the ASCEND Providers.. Expansion of Treatment for Hepatitis C Virus Infection by Task Shifting to Community-Based Nonspecialist Providers: A Nonrandomized Clinical Trial. Ann Intern Med. 2017 Sep 5;167(5):311-318. doi: 10.7326/M17-0118. Epub 2017 Aug 8. PubMed PMID: 28785771.
Wilson EM, Kattakuzhy S, Sidharthan S, Sims Z, Tang L, McLaughlin M, Price A, Nelson A, Silk R, Gross C, Akoth E, Mo H, Subramanian GM, Pang PS, McHutchison JG, Osinusi A, Masur H, Kohli A, Kottilil S. Successful Retreatment of Chronic HCV Genotype-1 Infection With Ledipasvir and Sofosbuvir After Initial Short Course Therapy With Direct-Acting Antiviral Regimens. Clin Infect Dis. 2016 Feb 1;62(3):280-288. PubMed PMID: 26521268; PubMed Central PMCID: PMC4706633.
Faldetta KF, Kattakuzhy S, Wang HW, Sereti I, Sheikh V. Cytomegalovirus immune reconstitution inflammatory syndrome manifesting as acute appendicitis in an HIV-infected patient. BMC Infect Dis. 2014 Jun 9;14:313. PubMed PMID: 24910267; PubMed Central PMCID: PMC4057562.
Hadigan C, Kattakuzhy S. Diabetes mellitus type 2 and abnormal glucose metabolism in the setting of human immunodeficiency virus. Endocrinol Metab Clin North Am. 2014 Sep;43(3):685-96. PubMed PMID: 25169561; PubMed Central PMCID: PMC4159723.
Wilson EM, Rosenthal ES, Kattakuzhy S, Tang L, Kottilil S. Clinical Laboratory Testing in the Era of Directly Acting Antiviral Therapies for Hepatitis C. Clin Microbiol Rev. 2017 Jan;30(1):23-42. PubMed PMID: 27795306; PubMed Central PMCID: PMC5217793.
Tang LS, Masur J, Sims Z, Nelson A, Osinusi A, Kohli A, Kattakuzhy S, Polis M, Kottilil S. Safe and effective sofosbuvir-based therapy in patients with mental health disease on hepatitis C virus treatment. World J Hepatol. 2016 Nov 8;8(31):1318-1326. PubMed PMID: 27872683; PubMed Central PMCID: PMC5099584.
Gross C, Akoth E, Price A, Kattakuzhy S, Silk R, Rosenthal E. HIV/HCV Co-infection: Overcoming Barriers to Treatment. J Assoc Nurses AIDS Care. 2016 Jul-Aug;27(4):524-9. PubMed PMID: 26996983.
Akoth E, Gross C, Silk R, Rosenthal E, Kattakuzhy S. A Practical Approach and Model of Care for HCV Treatment With Direct Acting Antivirals in an Urban Setting. J Assoc Nurses AIDS Care. 2017 Sep - Oct;28(5):680-684. doi: 10.1016/j.jana.2017.04.007. Epub 2017 Apr 26. PubMed PMID: 28506435.
In the last three years, my work has centered on the use of directly-acting antivirals in the treatment of hepatitis C mono-infection and co-infection with HIV. This work identified that combination short-duration antiviral therapy appears to be highly successful in early stage liver fibrosis, with moderate response rates in advanced fibrosis. These investigations also revealed that ultra-short DAA-based treatment had poor rates of response, and that patients treated with short-duration DAAs can successfully be re-treated. Overall this work has furthered the understanding of the limits of short duration hepatitis C therapy, with critical implications on a scientific and public health level. As the field of viral hepatitis has evolved, my contributions to the literature have targeted implementation-based improvements in the HCV care cascade, and hard-to-treat subpopulations of the hepatitis C epidemic.
2008 Primary Care Award and Scholarship, Eastern Virginia Medical School
2010 Intern of the Year, George Washington University Department of Medicine
2012 Resident of the Year, George Washington University Department of Medicine and INOVA Fairfax Hospital
2015 American Association for the Study of Liver Diseases Young Investigator’s Scholarship
2015 European Association for the Study of Liver Diseases Young Investigator’s Scholarship
2017 National Institute of Allergy and Infectious Disease Clinical Research Loan Repayment Program Award
2015-2018 Principal Investigator, Investigator Initiated Grant
2016-2017 Principal Investigator, Investigator Initiated Grant
GRAVITY FOCUS Award
2016-2017 Associate Investigator, Investigator Initiated Grant
IHV-Rwanda Community Education Collaboration (IRCEC)
2016-2018 Principal Investigator, Investigator Initiated Grant
2016-2018 Lead Associate Investigator, Investigator Initiated Grant
2016-2018 Lead Associate Investigator, Investigator Initiated Grant
Merck & Co.
2017-2022 Clinical and Administrative Director, DC Partnership for HIV/AIDS Progress
Hepatitis Clinical Research Program 5-year Programmatic Grant
Office of AIDS Research
|2014||Member, American Association for the Study of Liver Diseases|
|2015||Member, European Association for the Study of Liver Diseases|
|2016||Member, American Public Health Association|