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Curt I. Civin, MD

Associate Dean for Research; Director, Center for Stem Cell Biology & Regenerative Medicine

Academic Title:

Professor

Primary Appointment:

Pediatrics

Secondary Appointment(s):

Physiology

Administrative Title:

Associate Dean For Research; Director, Center For Stem Cell Biology & Regenerative Medicine

Additional Title:

Director of the Center for Stem Cell Biology & Regenerative Medicine; Associate Dean for Research

Location:

BRB, 14-021; HSF II, S103D (lab)

Phone (Primary):

(410) 706-1198

Phone (Secondary):

(410) 706-1181

Education and Training

  • Amherst College, BA, Biology/Independent Study, 1970
  • Harvard Medical School, MD, 1974
  • Residency, Children’s Hospital Medical Center, Pediatrics, 1976
  • Fellowships, Pediatric Hematology-Oncology, National Cancer Institute, National Institutes of Health, Immunology-1978, Pediatric Oncology-1979

Biosketch

Dr. Civin is a pioneer in cancer research who is known internationally for developing a way to isolate stem cells from other blood cells  The founding director for the University of Maryland’s Center for Stem Cell Biology & Regenerative Medicine, he has received wide recognition for his groundbreaking 1984 discovery of the CD34 antibody, which has had a major impact on the field of blood research. . Through his laboratory work, Dr. Civin accomplished the rare feat of making multiple discoveries that are used today not only in laboratory research but also in clinical bone marrow stem cell transplantation and leukemia diagnosis.

Dr. Civin holds 12 biomedical patents and is currently a principal or collaborating investigator on 11 peer-reviewed research projects funded by the National Institutes of Health, the state of Maryland Stem Cell Research Fund, the Leukemia & Lymphoma Society, the National Foundation for Cancer Research, and other private foundations. Dr. Civin taught and led research and clinical pediatric oncology at Johns Hopkins University School of Medicine for 30 years before becoming founding director for the University of Maryland’s Center for Stem Cell Biology & Regenerative Medicine and Associate Dean for Research. He has lectured around the world, published more than 250 articles and book chapters, received many awards, and served in leadership positions of multiple distinguished committees and editorial boards. Throughout his career, he has mentored a large number of talented scientists to pursue academic careers in translational research.

Research/Clinical Keywords

Stem Cell Biology, Regenerative Medicine, Pediatrics, Physiology, Pediatric Oncology, Gene Therapy, Pediatric Hematology, Childhood Cancer, Childhood Leukemia, Pediatric Bone Marrow Transplantation, Myeloid Diseases

Highlighted Publications

Tan Y.S., Kim M.J., Kingsbury T.J., Civin C.I., Cheng W.C. Regulation of RAB5C is important for the growth inhibitory effects of miR-509 in human precursor-B acute lymphoblastic leukemia. PLoS One 9:e111777, 2014. PMID: 25368993 PMCID: PMC4219775

Farrance, I.K., Civin, C.I. (eds.) Special Issue: Biochemistry of Stem Cells. In Biochimica et Biophysica Acta 1830, 2013.

Huang T.C., Cutler J., Bharne S., Zhong J., Weinstock D., Tyner J., Gojo I., Civin C.I., Pandey A. Integrated analysis of CRLF2 signaling in acute lymphoblastic leukemia identifies Polo-Like Kinase 1 as a potential therapeutic target. Leuk Lymphoma In Press, 2014. PMID: 25213184 PMCID: In process

Additional Publication Citations

Civin CI. CD34 stem cell stories and lessons from the CD34 wars: the Landsteiner Lecture 2009. Transfusion. 2010 Sep;50(9):2046-56. PubMed PMID: 20561292.

Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J Immunol. 1984 Jul;133(1):157-65. PubMed PMID: 6586833.

Beschorner WE, Civin CI, Strauss LC. Localization of hematopoietic progenitor cells in tissue with the anti-My-10 monoclonal antibody. Am J Pathol. 1985 Apr;119(1):1-4. PubMed PMID: 3885751; PubMed Central PMCID: PMC1888077.

Civin CI, Trischmann T, Kadan NS, Davis J, Noga S, Cohen K, Duffy B, Groenewegen I, Wiley J, Law P, Hardwick A, Oldham F, Gee A. Highly purified CD34-positive cells reconstitute hematopoiesis. J Clin Oncol. 1996 Aug;14(8):2224-33. PubMed PMID: 8708711.

Loken MR, Shah VO, Dattilio KL, Civin CI. Flow cytometric analysis of human bone marrow: I. Normal erythroid development. Blood. 1987 Jan;69(1):255-63. PubMed PMID: 2947644.

Loken MR, Shah VO, Dattilio KL, Civin CI. Flow cytometric analysis of human bone marrow. II. Normal B lymphocyte development. Blood. 1987 Nov;70(5):1316-24. PubMed PMID: 3117132.

Gore SD, Kastan MB, Civin CI. Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells. Blood. 1991 Apr 15;77(8):1681-90. PubMed PMID: 2015396.

Civin CI, Almeida-Porada G, Lee MJ, Olweus J, Terstappen LW, Zanjani ED. Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo. Blood. 1996 Dec 1;88(11):4102-9. PubMed PMID: 8943843.

Hurwitz CA, Loken MR, Graham ML, Karp JE, Borowitz MJ, Pullen DJ, Civin CI. Asynchronous antigen expression in B lineage acute lymphoblastic leukemia. Blood. 1988 Jul;72(1):299-307. PubMed PMID: 3291983.

Borowitz MJ, Shuster JJ, Civin CI, Carroll AJ, Look AT, Behm FG, Land VJ, Pullen DJ, Crist WM. Prognostic significance of CD34 expression in childhood B-precursor acute lymphocytic leukemia: a Pediatric Oncology Group study. J Clin Oncol. 1990 Aug;8(8):1389-98. PubMed PMID: 1696310.

Gore SD, Kastan MB, Goodman SN, Civin CI. Detection of minimal residual T cell acute lymphoblastic leukemia by flow cytometry. J Immunol Methods. 1990 Sep 14;132(2):275-86. PubMed PMID: 1698878.

Geller RB, Zahurak M, Hurwitz CA, Burke PJ, Karp JE, Piantadosi S, Civin CI. Prognostic importance of immunophenotyping in adults with acute myelocytic leukaemia: the significance of the stem-cell glycoprotein CD34 (My10). Br J Haematol. 1990 Nov;76(3):340-7. PubMed PMID: 1702006.

Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):459-63. PubMed PMID: 7507245; PubMed Central PMCID: PMC42968.

Hoehn GT, Stokland T, Amin S, Ramírez M, Hawkins AL, Griffin CA, Small D, Civin CI. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. Oncogene. 1996 Feb 15;12(4):903-13. PubMed PMID: 8632913.

Georgantas RW 3rd, Hildreth R, Morisot S, Alder J, Liu CG, Heimfeld S, Calin GA, Croce CM, Civin CI. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2750-5. PubMed PMID: 17293455; PubMed Central PMCID: PMC1796783.

Kim M, Tan YS, Cheng WC, Kingsbury TJ, Heimfeld S, Civin CI. MIR144 and MIR451 regulate human erythropoiesis via RAB14. Br J Haematol. 2015 Feb;168(4):583-97. PubMed PMID: 25312678; PubMed Central PMCID: PMC4314389.

Fox J.M., Moynihan J.R., Mott B.T., Mazzone J.R., Anders N.M., Brown P.A., Rudek M.A., Liu J.O., Arav-Boger R., Posner G.H., Civin C. I., Chen X. Artemisinin-Derived Dimer ART-838 Potently Inhibited Human Acute Leukemias, Persisted in Vivo, and Synergized with Antileukemic Drugs. Oncotarget 7:7268-7279, 2016. PubMed PMID: 26771236; PubMed Central PMCID: PMC4872784

Research Interests

Awards and Affiliations

  • National Inventor of the Year Award, 1999
  • Editor-in-Chief, Stem Cells, 2000-2007
  • America’s Top Doctors, 2001-present
  • Return of the Child Award, Leukemia Lymphoma Society, (the Society’s highest honor), 2006
  • Karl Landsteiner Memorial Award & Lectureship, American Association of Blood Banks, 2009
  • The John L. Kellerman III Memorial Lecture (2011 Keynote), Maryland Stem Cell Research Fund Annual Meeting
  • 2015 American Society of Hematology Mentor Award, 2015

Previous Positions

  • Active Staff in Oncology and Pediatrics, The Johns Hopkins Hospital, Baltimore, MD, 1979-2009
  • Assistant Professor, Associate Professor, Professor, Oncology and Pediatrics, The Johns Hopkins University School of Medicine, 1979-2009