Update Your ProfileAcademic Title:
Professor
Primary Appointment:
Medicine
Additional Title:
Professor of Medicine, Division of Clinical Care and Research, Institute of Human Virology
Location:
Institute of Human Virology, N548
Phone (Primary):
410-706-1779
Fax:
410-706-1992
Education and Training
B.A., University of Virginia
M.D., University of Maryland School of Medicine
Research/Clinical Keywords
Antibody isolation and engineering, B cell responses and development, HIV-1 Humoral Immunity, HIV-1 Elite Controllers
Highlighted Publications
1) Sajadi MM, Dashti A, Rikhtegaran Tehrani Z, Tolbert WD, Seaman MS, Ouyang X, Gohain N, Pazgier M, Kim D, Cavet G, Yared J, Redfield RR, Lewis GK, DeVico AL. Identification of near pan-neutralizing antibodies against HIV-1 by deconvolution of plasma humoral responses. Cell. 2018 Jun 14;173(7):1783-1795. PMCID: PMC6003858
2) Saadat S, Rikhtegaran Tehrani Z, Logue J, Newman M, Frieman MB, Harris AD, Sajadi MM. Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2. JAMA. 2021 Apr 13;325(14):1467-1469. doi: 10.1001/jama.2021.3341. PMID: 33646292
3) Tehrani ZR, Habibzadeh P, Flinko R, Chen H, Abbasi A, Yared JA, Ciupe SM, Lewis GK, Sajadi MM. Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection. J Infect Dis. 2024 Jul 25;230(1):e30-e33. doi: 10.1093/infdis/jiad603. PMID: 39052732
4) Sajadi MM, Abbasi A, Tehrani ZR, Siska C, Clark R, Chi W, Seaman MS, Mielke D, Wagh K, Liu Q, Jumpa T, Ketchem RR, Nguyen DN, Tolbert WD, Pierce BG, Atkinson B, Deming D, Sprague M, Asakawa A, Ferrer D, Dunn Y, Calvillo S, Yin R, Guest JD, Korber B, Mayer BT, Sato AH, Ouyang X, Foulke S, Habibzadeh P, Karimi M, Aslanabadi A, Hojabri M, Saadat S, Zareidoodeji R, Kędzior M, Pozharski E, Heredia A, Montefiori D, Ferrari G, Pazgier M, Lewis GK, Jardine JG, Lusso P, DeVico A. A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV. Structure. 2025 Jul 3;33(7):1150-1164.e8. doi: 10.1016/j.str.2025.04.016. Epub 2025 May 14. PMID: 40373766
Research Interests
Dr. Sajadi is Infectious Diseases physician and researcher, and his research focuses on antibodies. His lab works on understanding antibody and B cell responses to infection and vaccination, isolation and engineering of antibodies, as well as developing immunotherapies for viral diseases, including such viruses as HIV and Crimean-Congo Hemorrhagic Fever Virus, and Varicella-Zoster Virus. He has been funded by the NIH, Gates Foundation, and Veterans Administration.