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Translational Genomics Laboratory


The mission of the TranslationalGenomics Laboratory (TGL) is to provide a critical bridge to help accelerate translation from discovery into precision health care, by providing DNA sequencing, genotyping and array-based technologies in both a basic research and clinically-regulated environment.



About the TGL

The Translational Genomics Laboratory (TGL) is the result of 35 years of core facility evolution, starting with peptide and oligonucleotide synthesis, to the current CAP (College of American Pathologists) accredited and CLIA (Clinical Laboratory Improvement Amendments) compliant laboratory, capable of providing support to clinical and translational genetic/genomics studies (CAP# 8017554; CLIA# 21D2027356).

TGL is part of the University of Maryland School of Medicine’s Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCC), the Program for Personalized and Genomic Medicine (PPGM), and the Center for Innovative Biomedical Resources (CIBR).

The services offered by the TGL support basic research. The clinical assays offered are similar to those offered to support basic research, except that these assays are validated under CLIA, enabling them to be used in the clinical decision-making process in research protocols and for routine patient care.



Services (Clinical)


Services (Basic Research)

  • Cytogenomic Arrays
  • Extraction of Nucleic Acid
    • DNA
    • RNA
  • Gene Expression Arrays
    • Global Expression Profiling
    • miRNA Expression Profiling
    • Transcriptome Analysis
  • Genotyping
    • Taqman Assays
  • Next Generation Sequencing (NGS) Gene Panels
  • Sanger DNA Sequencing

TGL Image 01




  • Applied Biosystems 3730XL (Sanger sequencing)
  • Affymetrix GeneChip system 3000 7G (chip-based arrays, e.g. CytoScan HD, DMET)
  • Applied Biosystems 9700 thermocycler (PCR amplification)
  • Nanodrop single-channel and 8-channel spectrophotometers
  • ThermoFisher QuantStudio 5
  • Ion Torrent Personal Genome Machine (next generation sequencing panels, e.g. Comprehensive Cancer Panel, and Custom AmpliSeq panels)
  • Ion Chef System
  • Ion S5 Sequencer

TGL Image 02a

Quant Studio 5 Amplication Plot

TGL Image 02

Quant Studio 5 Experiment


TGL Image 03

ISP Loading/Run Summary

Forms and Documents

CAP Accreditation Certificate

CLIA Certificate of Accreditation 2024 to 2026

Medical Laboratory Permit

QA-506 Clinical Services Test Requisition

QA-514 Clinical Services Test Requisition Extract and Hold Only

QA-36 Clinical Research Project Request

Suggestion Box

Satisfaction Survey


Aaron Rapoport

Aaron P. Rapoport, MD

Professor of Medicine
Gary Jobson Professor
in Medical Oncology
Director of Transplant and
Cellular Therapy (TCT) Program
Head, Division of
Director of Translational
Genomics Laboratory

Nick Ambulos

Nicholas P. Ambulos, PhD

Director, Genomics Core Facility 

Danielle Sewell, BS

Danielle Sewell, MSRS

Compliance Manager



Room 7-037
Bressler Research Building
655 West Baltimore Street
Baltimore, MD 21201


Monday through Friday,
8:00am - 5:00pm


Lab: 410-706-3339
Fax: 410-706-0287

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