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Research

Vaccinology is a multidisciplinary scientific and medical field that encompasses and incorporates bacteriology, virology, parasitology, immunology, molecular biology, structural biology, epidemiology, public health, clinical trials, translational medicine, pediatrics, internal medicine, biostatistics, anthropology, ethics, fermentation engineering and, as necessary, other areas of expertise. 

‌The CVD conducts research that ranges from basic laboratory investigations of pathogens, mechanistic aspects of immunity, and construction of vaccine development through pre-clinical animal model studies, performance of early small-scale (Phase 1 and 2) clinical trials, large-scale pivotal Phase 3 efficacy trials, and post-licensure trials. 

While the main research thrust at the CVD has historically focused on bacterial enteric pathogens, rotavirus, and malaria, it has also worked more broadly in the areas of bacterial diseases, parasitic diseases, viral diseases, novel delivery systems, public health and vaccine policy. As a result of many of these endeavors, the CVD generates intellectual property available for licensing by commercial entities.

 

Research initiatives

The CVD has successfully developed and evaluated vaccines from laboratory to licensure.

Examples of our success:

  • Developed cholera vaccine licensed by FDA in 2016
  • Led pivotal trials for a typhoid vaccine
  • Conducted trials of the live attenuated intranasal flu vaccine and multiple pandemic flu vaccines requiring rapid implementation
  • Instrumental in malaria vaccine development, maintaining a mosquito insectary, and performing controlled human malaria infection studies
  • Pioneered the first clinical trial of an edible vaccine to prevent diarrhea
  • Developed human infection challenge models for Shigella, diarrheagenic E. coli, and cholera

Vaccine development

Vaccine research