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Translational Genomics Laboratory

MISSION:

The mission of the Translational Genomics Laboratory is to provide a critical bridge to help accelerate translation from discovery into precision health care, by providing DNA sequencing, genotyping and arraybased technologies.


ABOUT:

The Translational Genomics Laboratory (TGL) is a CAP (College of American Pathologists) accredited and CLIA (Clinical Laboratory Improvement Amendments) compliant laboratory, capable of providing support to clinical and translational genetic/genomic studies (CAP# 8017554) (CLIA# 21D2027356). TGL is part of the University of Maryland School of Medicine’s Program for Personalized and Genomic Medicine (PPGM) and the Center for Innovative Biomedical Resources (CIBR).

The services offered by the TGL are similar to those offered in traditional academic genomic core labs, except that these assays are validated under CLIA which allows them to be used in the clinical decision-making process in research protocols and for routine patient care.


SERVICES:‌

  • BTD Sequencing
  • Confirmation of a Research Finding
  • CYP2C19 Genotyping
  • CYP2C19 Sequencing
  • Cytogenomic Microarray
  • Extract and Hold
  • FLT3 ITD and TKD Analysis
  • IDH1 R132_IDH2 R140 and R172
  • Site-specific Familial variant analysis‌

TGL Image 01


‌‌INSTRUMENTATION:

  • Applied Biosystems 3730XL (Sanger sequencing)
  • Affymetrix GeneChip system 3000 7G (chip-based arrays, e.g. CytoScan HD, DMET)
  • Applied Biosystems 7900 RT-PCR system (genotyping by Taqman©-based methods)
  • Applied Biosystems 9700 thermocycler (PCR amplification)
  • Nanodrop single-channel and 8-channel spectrophotometers
  • ThermoFisher QuantStudio 5
  • Ion Torrent Personal Genome Machine (next generation sequencing panels, e.g. Comprehensive Cancer Panel, and Custom AmpliSeq panels)
  • Ion Chef System
  • Ion S5 Sequencer

TGL Image 02a

Quant Studio 5 Amplication Plot

TGL Image 02

Quant Studio 5 Experiment

 

TGL Image 03

ISP Loading/Run Summary


Forms and Documents

CAP Accreditation Certificate

CLIA Certificate of Compliance

Medical Laboratory Permit

QA-506 Clinical Services Test Requisition

QA-514 Clinical Services Test Requisition Extract and Hold Only 

QA-36 Clinical Research Project Request

Suggestion Box

Satisfaction Survey


CONTACT:

Ying Zou, MD, PhD, FACMG

Ying Zou, MD, PhD, FACMG

Director, Associate Professor
Department of Pathology
University of Maryland Pathology Associates, P.A.

Danielle Sewell, BS

Danielle Sewell, BS

Compliance Manager

410-706-3339


LOCATION:

Room 7-037
Bressler Research Building
655 West Baltimore Street
Baltimore, MD 21201


HOURS:

Monday through Friday,
8:00am - 5:00pm


PHONE

Lab: 410-706-3339
Fax: 410-706-0287

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