March 18, 2021 | Deborah Kotz
Senior Director of Media Relations
Office of Public Affairs & Communications
University of Maryland School of Medicine
Wednesday, August 24, 2022
Fecal transplants have been successful in treating serious diarrheal infections but have often failed when tried with other diseases. Up until now, no one could predict why these treatments sometimes failed to help restore healthy bacteria in the colon. Researchers from the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) have discovered important clues that could lead more personalized approaches to optimize treatment success. They published their findings in Cell Reports Medicine online earlier this month.
Monday, July 18, 2022
New Genomic Research Shows Why Testing Malaria Vaccines in the Clinic is as Rigorous as Natural Exposure in the Field
Malaria is the deadliest mosquito-borne parasitic infection of humans. In 2021, after a century of research, the World Health Organization (WHO) approved the world’s first malaria vaccine. That vaccine reduces the incidence of malaria infections in young children aged 5-17 months by only 30 percent, meaning that it remains critical to continue developing and testing more effective vaccines.
Thursday, June 23, 2022
New Research Shows Mothers’ HIV Status, Breastfeeding, and the Infant Gut Microbiome Can Have Long-Term Impact on Infant Health
Babies born to women with HIV often have poorer health and under-developed growth in the early months of life than infants born to women without the infection — even if those babies don’t contract HIV during birth, according to a new study by researchers at the University of Maryland School of Medicine (UMSOM)’s Institute for Genome Sciences (IGS) and Institute of Human Virology (IHV). The study also provides new insights into why these health issues often continue throughout the babies’ lives.
Monday, September 20, 2021
UM School of Medicine Receives $7.5 Million Grant to Create Complex Model of Female Reproductive Tract to Study Infections
Researchers at the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine have received a $7.5 million federal grant to create a complex model of the female reproductive system in order to study sexually transmitted infections (STIs). They plan to create a realistic 3D model that integrates vaginal and cervical epithelial cells and the bacteria that colonize these cells, called a microbiome. They aim to use this model to identity factors that play a role in chlamydia and gonorrhea infections experienced by a growing number of women in the U.S. and worldwide.
Wednesday, September 15, 2021
Probiotic-Containing Yogurt Protects Against Microbiome Changes That Lead to Antibiotic-Induced Diarrhea, Study Finds
Eating yogurt containing a particular strain of a well-studied probiotic appears to protect against harmful changes in the gut microbiome that are associated with antibiotic administration. That is the finding from a new randomized clinical trial, led by researchers at the University of Maryland School of Maryland (UMSOM), the University of Maryland School of Pharmacy (UMSOP), and Georgetown University Medical Center, which was recently published in the journal Nutrients.
Thursday, February 25, 2021
UM School of Medicine Researchers Participate in Landmark Study Detailing Sequencing of Full Human Genomes to Better Capture Genetic Diversity
Researchers at the University of Maryland School of Medicine (UMSOM) co-authored a study, published today in the journal Science, that details the sequencing of 64 full human genomes. This reference data includes individuals from around the world and better captures the genetic diversity of the human species. Among other applications, the work will enable population-specific studies on genetic predispositions to human diseases as well as the discovery of more complex forms of genetic variation.
Wednesday, February 26, 2020
Researchers Develop First Catalogue of Genes that Comprise Community of Microbes in Vaginal Microbiome
University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) researchers have created the first catalogue of genes that comprise the community of microbes, which inhabit the human vagina. The catalogue, called human vaginal non-redundant gene catalog (VIRGO), was recently released as a public resource that can be used by researchers to facilitate a more in-depth understanding of the role of vaginal microorganisms in women’s health and to potentially develop future treatments for certain gynecologic conditions.
Tuesday, December 03, 2019
UM School of Medicine Researchers Institute for Genome Sciences' Researchers Discover Potential New Treatment for Tropical Parasitic Disease Using Genomics
Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine (UMSOM) Institute for Genome Sciences identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat. The potential new therapy is an experimental cancer drug called JQ1 and targets proteins found prominently in the worm’s genome; it appears to effectively kill the adult worms in a laboratory setting, according to the study which was published today in the journal mSystems.
Tuesday, August 13, 2019
The vaginal microbiome is believed to protect women against Chlamydia trachomatis, the etiological agent of the most prevalent sexually transmitted infections (STIs) in developed countries. New research by the University of Maryland School of Medicine (UMSOM) shows how the microbiome can either protect or make a woman more susceptible to these serious infections.
Wednesday, March 27, 2019
Spontaneous preterm birth (sPTB), defined as birth before 37 weeks of gestation, and the related complications, are the largest contributors to infant death in the United States and worldwide, according to the World Health Organization. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered that bacteria and innate immune factors in a woman’s birth canal and cervix may increase the risk of spontaneous preterm birth or provide protection against such births.
Tuesday, February 12, 2019
Researchers at the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine (UMSOM) called for open access to genome data, stating that unrestricted usage is needed for progress in combating the world’s most serious diseases.
Tuesday, December 04, 2018
UMSOM/UMSOP Researchers Awarded $1.78 Million Grant to Study Brain-To-Gut Connection in Schizophrenia
Researchers at the University of Maryland School of Medicine’s (UMSOM) Maryland Psychiatric Center (MPRC) and Institute for Genome Sciences (IGS), along with researchers at the University of Maryland School of Pharmacy (UMSOP), have been awarded a collaborative five-year $1.78 million grant to study the brain-to-gut connection in schizophrenia.
Tuesday, October 11, 2016
Led by investigators at the University of Maryland School Of Medicine, a national group of researchers has confirmed for the first time that two of the top genomic databases, which are in wide use today by clinical geneticists, reflect a measurable bias toward genetic data based on European ancestry over that of African ancestry. The results of their study were published today in the journal Nature Communication.
Wednesday, May 25, 2016
A University of Maryland School of Medicine researcher has helped develop an innovative computing technique that, on very large amounts of data, is both faster and more accurate than current methods. To spur research, a program using this technique is being offered for free to the biomedical research community.
Monday, February 08, 2016
A multi-disciplinary group of researchers at the University of Maryland School of Medicine (UM SOM) have for the first time determined the genetic makeup of various strains of E. coli, which every year kills hundreds of thousands of people around the world.
Thursday, January 21, 2016
The White House has awarded Robert E. Fischell, ScD, a member of the University of Maryland School of Medicine (UM SOM) Board of Visitors, the National Medal of Technology and Innovation, the highest honor for technological achievement bestowed by the president of the United States. Previous recipients have included such luminaries as Steven Jobs and Stephen Wozniak (Apple Computer, Inc.), Stephen D. Bechtel, Jr. (Bechtel Group, Inc.), David Packard (Hewlett-Packard Company), Clarence L. Johnson (Lockheed Corporation), Edwin H. Land (Polaroid Corporation) and Edith Flanigen (Union Carbide).