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Active Grant Support

Listed by last name of Principal Investigator.

Title: Reducing Disability Via a Bundled Bio-Behavioral-Environmental Approach (Subcontract)

Principal Investigator: Jack Gurlanik, PhD
Agency: NIH/NIA
Funding Period: 4/1/12 – 3/31/17
Total Direct Costs: $66,440

Disability is the result of a mismatch between an individual’s physical and cognitive capabilities and the demands of their environment. The goal of this randomized controlled trial is to test the hypothesis that in frail, community-dwelling older persons a combination of physical exercise supervised by a physical therapist and modification of the home environment, accomplished by a handyman by making repairs and additions in deficient areas, will reduce the progression of disability and improve quality of life.

Title: The Role of Vascular Aging In Cognitive and Physical Function (Subcontract)

Principal Investigator: Jack Guralnik, PhD
Agency: NIH/NIA
Funding Period: 7/1/12 – 6/30/17
Total Direct Costs: $66,440

The life course approach in epidemiology has demonstrated that early life factors may play an important role in aging outcomes. This study will do a follow up on the Bogalusa Heart Study cohort, which is a cohort of black and white persons in rural Louisiana that has been followed since the early 1970’s, when they were young adults. It will focus on cognitive and physical functional outcomes and relate early life factors, particularly cardiovascular disease risk factors, to outcomes in this cohort which is now entering old age.

Title: Resilience to Mobility Impairment: Neural Correlates and Protective Factors (Subcontract)

Principal Investigator: Jack Gurlanik, PhD
Agency: NIH/NIA
Funding Period: 5/1/2012 – 4/30/16
Total Direct Costs: $116,805

Brain changes observed on magnetic resonance imaging (MRI) are highly correlated with limitations in physical and cognitive functioning. However, there is a substantial subset of the older population that has brain abnormalities on MRI, particularly white matter lesions that would be expected to be associated with functional decrements in mobility but are not. This study will target these individuals and attempt to explain what protective factors might be reducing the impact of these changes on mobility impairment.

 

Title: University of Maryland Claude D. Pepper Older Americans Independence Center

Principal Investigator:  Jay Magaziner, PhD, MSHyg 

Agency: NIH/NIA
Grant Number: 5P30AG028747
Funding Period:  07/01/2016 – 06/30/2021
Total Costs: $5,091,455

The overarching UM-OAIC goal is to build on the sciences and therapeutic applications of exercise and rehabilitation by: 1) advancing our understanding of the mechanisms by which exercise and activity-based rehabilitation interventions directed at specific impairments affect multiple body systems underlying functional performance; and 2) developing and testing interventions to restore function and minimize disability following acute disabling events and gradual declines related to serious chronic diseases. The functional impairments and disabilities that occur in Older people emanate from acute events, such as stroke, heart attack, and hip fracture, or reflect the progression of chronic diseases. Older people aging with chronic diseases have a reduced aerobic capacity and develop sarcopenia, fatigue, and neuromotor and cognitive impairments that reduce their physiological reserve, impair their ability to function independently, and increase their level of medical care and risk for institutionalization and death. This pathway of how disease leads to disability has been discussed extensively. The UM-OAIC mission embodies this process and focuses on the restoration of function in order to improve function in those with impairments, and prevent or delay further progression in those who are already disabled. This has been aptly referred to as enablement. (9,10) The UM-OAIC will continue to focus its research on enablement by identifying the impairments associated with disabling conditions, investigating the mechanisms and pathophysiology of the impairments, developing exercise and activity-based interventions that target these mechanisms and deficits, testing them in clinical laboratories/centers, and then adapting them for implementation and further testing in community settings. The aims of the UM-OAIC are to: 1) Conduct research that examines the mechanisms underlying the functional impairments associated with stroke, hip fracture, and prevalent chronic diseases in Older people. 2) Design novel, exercise and activity-based rehabilitation interventions that produce clinically relevant outcomes and study the mechanisms underlying them. 3) Translate interventions developed in UM-OAIC clinical laboratories and in other clinical centers for implementation and rigorous evaluation in community settings. 4) Support pilot and exploratory studies (PESs), development projects (DPs) and externally funded projects (EP) that examine the mechanisms underlying disability and the processes of recovery, and that design and test interventions for the restoration and maintenance of function in clinical laboratories and settings outside the medical Center. 5) Foster the career development of junior faculty/scholars from multiple disciplines into independent, academic scientists with expertise in the study of Older persons with disabling diseases through mentor-based, bench-to-bedside translational research training that includes didactic and experiential/practical- applied training in conducting independent, aging research. 

Title: Effects of Multi-Modal Exercise Intervention Post Hip Fracture

Principal Investigator: Jay Magaziner, PhD
Agency: NIH/NIA
Funding Period: 9/1/11 – 6/30/16
Total Direct Costs: $3,497,870

The goal of this study is to evaluate some of the key mechanisms on the pathway to changes in community ambulation in response to a Multi-Modal Intervention delivered to this frail and disabled group of older persons. This is being done as an ancillary study to a Phase III randomized clinical trial (1R01AG035009).

Title: Community Ambulation Following Hip Fracture

Principal Investigator: Jay Magaziner, PhD
Agency: NIA
Funding Period: 9/1/10-8/31/2015
Total Direct Costs: $11,843,303

This randomized controlled multi-center study will evaluate the effect of a 4 month, home delivered muti-component intervention on survival and the ability to ambulate independently in the community among older men and women who have sustained a hip fracture. The project also will investigate precursors to community ambulation and the cost effectiveness of delivering the program to this frail and disabled population of older persons.

Title: The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in Men

Principal Investigator: Jay Magaziner, PhD
Agency: NIH
Funding Period: 03/01/07—02/29/14
Total Direct Costs: $2,994,863

This ancillary study is designed to extend the investigation of the hip fracture consequences further by examining trajectories of change in bone strength, bone metabolism, muscle composition, hormones, and markers of inflammation following hip fracture, and by comparing these changes in men and women during the year following a hip fracture.

Title: Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture

Principal Investigator: Denise Orwig

Agency: Washington University (NIH Passthrough)
Grant Number:
1R01AG051647 (Binder)
Funding Period: 09/15/2017 – 05/31/2022
Total Costs: $2,696,085

Hip fractures are common among older women and can have a devastating impact on their ability to remain independent. A clinically important functional decline and failure to recover following a hip fracture has been documented as much as a year after the fracture, even among individuals who were functioning at high levels before the event. Age-associated androgen deficiency in women contributes to deficits in muscle mass, strength and power that are common in this patient population before the fracture, and are exacerbated afterward. A pilot study of Testosterone (T) supplementation in elderly female hip fracture patients has demonstrated the feasibility of T treatment in this population, and showed gains in lean body mass (LBM) and muscle strength with active drug, compared to placebo. The benefits of exercise in restoring muscle strength and physical function after a hip fracture have been documented. However, it remains unclear whether T treatment can augment the effects of exercise on mobility and patient-reported function, or whether any observed benefits are sustained beyond the period of active treatment. Proposed is a 3-group, multi-center, randomized, placebo-controlled, double-blinded, parallel group clinical trial in frail elderly female hip fracture patients. 300 female hip fracture patients will be enrolled from 6 clinical sites, using objective screening criteria for T deficiency (serum total Testosterone level < 30 ng/dl) and physical frailty (Modified Physical Performance Test (PPT) Score < 28). The trial will compare the effects of supervised exercise training (EX) alone, EX combined with T therapy (EX+T) and no EX with placebo T treatment (CON), to ascertain the incremental impact of adding T to ET in older adult women following hip fracture. The 6-month intervention will be followed by a 6-month no-treatment sustainability phase. The primary outcome measure is the Six Minute Walk Distance (6MWD). Secondary outcome measures include: 1) dual energy x-ray absorptiometry (DXA) measurements of whole body and appendicular LBM and bone mineral density of the unfractured proximal femur; 2) maximal skeletal muscle strength (1-RM) for leg extension in both limbs; 3) objective physical performance measures; and 4) self-reported performance of activities of daily living and quality of life, including the Hip Rating Questionnaire (HRQ). We plan to carefully monitor Testosterone levels, adverse events, biochemical parameters, and factors related to adherence to the interventions. Information from this study has the potential to alter treatment of hip fracture in older women, a problem that contributes to significant morbidity and mortality, and has a large public health impact. The proposed study is highly aligned with NIA’s mission of identifying interventions that target common geriatric conditions, and improve treatment options for older adults with multiple morbidities or risk factors.

Title: Progenitor Cell Biology Consortium Administrative Coordinating Center

Principal Investigator: Michael Terrin, MD
Agency: NHLBI
Funding Period: 09/30/09-09/29/16
Total Direct Costs: $28,669,691

The Progenitor Cell Biology Consortium Administrative Coordinating Center will make available to the public accessible video reports on the research accomplishments of the Consortium, to the general scientific community reports and data from the Consortium that will advance their research on stem and progenitor cell related health problems and to the members of the Consortium data and meta-data from each other’s work to advance their collaborative research. In addition to providing all involved with newly developed, valuable information, the exchange of this information is expected to result in new therapeutic approaches that could shift paradigms and enormously improve outcomes of some of the most frequently fatal diseases in the U.S.; coronary artery disease and emphysema are just two examples.

Title: Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT)

Principal Investigator: Michael Terrin, MD
Agency: NIA
Funding Period: 08/15/11-07/31/16
Total Direct Costs: $11,716,411

The primary aim of this multi-site clinical trial is to determine if doxycycline (100mg bid) will inhibit by at least 40% the increase in greatest transverse diameter of small abdominal aortic aneurysms over a 24-month period of observation in comparison to a placebo-treated control group.