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Raphael P.H. Meier, MD, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Surgery

Location:

29 S. Greene Street, Suite 200

Phone (Primary):

(410) 328-5408

Fax:

(410) 328-6343

Education and Training

1999: Scientific baccalaureate, Switzerland

2007 - 2013: M.D.-Ph.D., Faculty of Medicine, University of Geneva, Switzerland

2007 - 2015: Residency, General Surgery, Geneva University Hospital, Switzerland

2016: Board certification, Surgery, Berne, Switzerland

2015 - 2017: Fellowship, General Surgery, Geneva University Hospital, Switzerland

2018 - 2020: Liver, Kidney, and Pancreas Transplant Surgery, Department of Surgery, University of California, San Francisco, USA

Biosketch

Raphael P. H. Meier, M.D., Ph.D. is a Transplant Surgeon and researcher in the Department of Surgery and Transplant Surgery at University of Maryland. Dr. Meier's research is focused on the development of Mesenchymal Stem Cell transplantation as a therapeutic modality to deliver anti-inflammatory cytokines to treat liver fibrosis and nonalcoholic steatohepatitis. Another part of his research focuses on the development of new strategies to improve outcomes after Islet Transplantation for the treatment of type I diabetes.

Research/Clinical Keywords

Liver transplantation, Kidney transplantation, Pancreas and islet cell transplantation, Mesenchymal stem cells

Highlighted Publications

 

Meier R, Noguchi H, Kelly Y, Sarwal M, Conti G, Ward C, Halleluyan R, Tavakol M, Stock P, Freise C. Impact of Sarcopenia on Simultaneous Pancreas and Kidney Transplantation Outcomes: A Retrospective Observational Cohort Study. Transplantation direct. 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523826/  

Meier R, Meyer J, Muller Y, Szot G, Bedat B, Andres A, Masse N, Lalbanche S, Puppa G, Bosco D, Berney T. Pancreas collagen digestion during islet of Langerhans isolation. Transplant international. 2020 Aug 27. doi: 10.1111/tri.13725. https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13725

Longchamp A, Klauser A, Songeon J, Agius T, Nastasi A, Ruttiman R, Moll S, Meier R, Buhler L, Corpataux JM, Lazeyras F. Ex Vivo Analysis of Kidney Graft Viability Using 31P Magnetic Resonance Imaging Spectroscopy. Transplantation. 2020 Jul 1. https://doi.org/10.1097/tp.0000000000003323 

Meier R, Müller Y, Dietrich PY, Tille JC, Nikolaev S, Sartori A, Labidi-Galy I, Ernandez T, Kaur A, Hirsch H, McKee T, Toso C, Villard J, Berney T. Immunologic clearance of a BK virus-associated metastatic renal allograft carcinoma. Transplantation 2020https://pubmed.ncbi.nlm.nih.gov/32091486/ 

Müller Y, Meier R. Targeting laminin 511, a new pathway to promote organ tolerance? Transplantation 2019 Apr 25. https://pubmed.ncbi.nlm.nih.gov/31033650/ 

Longchamp A*, Meier R*, Colucci N, Balaphas A, Orci L, Nastasi A, Longchamp G, Moll S, Klauser A, Lazeyras F, Pascual M, Corpataux JM, Bühler L (*co-first authors). Impact of an intra-abdominal cooling device during open kidney transplantation in pigs. Swiss Medical Weekly 2019 Dec 23;149:w20143. https://smw.ch/article/doi/smw.2019.20143

Meier R, Syed S, Roberts JP. Re: Biliary Bicarbonate, pH and Glucose Are Suitable Biomarkers of Biliary Viability During Ex Situ Normothermic Machine Perfusion of Human Donor Livers. Transplantation. Jan 2019. https://pubmed.ncbi.nlm.nih.gov/31568215/ 

Ostermann S, Morel P, Chale JJ, Bucher P, Konrad B, Meier R, Ris F, Schiffer ERC. Randomized Controlled Trial of Enhanced Recovery Program Dedicated to Elderly Patients After Colorectal Surgery. Dis Colon Rectum. 2019 Jul 12. https://pubmed.ncbi.nlm.nih.gov/31318772/ 

Meier R, Meyer J, Montanari E, Lacotte S, Balaphas A, Muller Y, Clément S, Negro F, Toso C, Morel P, Buhler L. Interleukin-1 receptor antagonist modulates liver inflammation and fibrosis in mice in a model-dependent manner. International Journal of Molecular Sciences, 2019. https://www.mdpi.com/1422-0067/20/6/1295 

Meier R, Andrey D, Sun P, Niclauss N, Bédat B, Demuylder-Mischler S, Borot S, Benhamou PY, Wojtusciszyn A, Buron F, Pernin N, Muller Y, Bosco D, van Delden C, Berney T. Pancreas preservation fluid microbial contamination is associated with poor islet isolation outcomes. Transplant international. 2018; 31(8):917-929. https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13159

Montanari E, Pimenta J, Szabó L, Noverraz F, Passemard S, Meier RPH, Meyer J, Sidibe J, Thomas A, Schuurman HJ, Gerber-Lemaire S, Gonelle-Gispert C, Buhler LH. Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocyte Viability and Albumin Secretion. Journal of Immunology Research. 2018 Jan 11; https://www.hindawi.com/journals/jir/2018/1078547/

Meier R, Muller YD, Balaphas A, Morel P, Pascual M, Seebach J, Bühler LH. Xenotransplantation: Back to the future? Transplant international. 2018; 31(5):465-477. https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.13104

Meier R, Piller V, Hagen ME, Joliat C, Buchs JB, Nastasi A, Ruttimann R, Buchs NC, Moll S, Vallée JP, Lazeyras F, Morel P, Bühler L. Intra-abdominal cooling system limits ischemia-reperfusion injury during robot-assisted renal transplantation. American journal of transplantation. 2018; 18(1):53-62. https://onlinelibrary.wiley.com/doi/full/10.1111/ajt.14399

Schuetz C, Anazawa T, Cross SE, Labriola L, Meier RPH, Redfield RR 3rd, Scholz H, Stock PG, Zammit NW; IPITA YIC Young Investigator Committee. ß cell replacement therapy: the next 10 years. Transplantation 2018; 102(2):215-229. https://bit.ly/2C3TipR 

Montanari E, Meier R, Mahou R, Seebach JD, Wandrey C, Gerber-Lemaire S, Buhler LH, Gonelle-Gispert C. Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice. Stem Cell Research & Therapy. 2017 Sep 29;8(1):199. doi: 10.1186/s13287-017-0646-7. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0646-7

Meier R, Montanari E, Morel P, Pimenta J, Schuurman HJ, Wandrey C, Gerber-Lemaire S, Mahou R, Bühler L. Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications. P. Stock and Christ B. (eds.), Methods in Molecular Biology, Hepatocyte Transplantation (2017). https://link.springer.com/protocol/10.1007/978-1-4939-6506-9_18

Meier R, Fournier I, Toso C, Berney T, Bednarkiewicz M. Surgical repair of a living-donor kidney graft artery kink by a post anastomotic external iliac artery rotation and re-anastomosis. Annals of Vascular Surgery. 2017 May 4. https://www.sciencedirect.com/science/article/pii/S0890509617300109?via%3Dihub

Oldani G, Peloso A, Lacotte S, Meier R, Toso C. Xenogeneic chimera—Generated by blastocyst complementation—As a potential unlimited source of recipient-tailored organs. Xenotransplantation 2017; 24(4). https://onlinelibrary.wiley.com/doi/abs/10.1111/xen.12327

Lavallard V, Armanet M, Parnaud G, Meyer J, Barbieux C, Montanari E, Meier R, Morel P, Berney T, Bosco D. Cell rearrangement in transplanted human islets. FASEB J. 2016 Feb;30(2):748-60. https://www.fasebj.org/doi/abs/10.1096/fj.15-273805

Niclauss N, Meier R, Bédat B, Berishvili E, Berney T. Beta-Cell Replacement: Pancreas and Islet Cell Transplantation. Stettler C, Christ E, Diem P (eds): Novelties in Diabetes. Endocr Dev. Basel, Karger 2016, vol 31, pp 146–162. https://www.karger.com/Article/Abstract/439412

Meier R, Toso C, Terraz S, Breguet R, Berney T, Andres A, Jannot AS, Rubbia-Brandt L, Morel P, Mentha G, Majno P. Improved liver function after portal vein embolization and elective right hepatectomy. HPB (Oxford). 2015 Nov;17(11):1009-18. https://www.sciencedirect.com/science/article/pii/S1365182X15320098?via%3Dihub

Meier R, Navarro-Alvarez N, Morel P, Schuurman HJ, Strom S, Bühler LH. Current status of hepatocyte xenotransplantation. Int J Surg. 2015 Sep 9. https://www.sciencedirect.com/science/article/pii/S1743919115011899

Lejmi E, Perriraz N, Clément S, Morel P, Baertschiger R, Christofilopoulos P, Meier R, Bosco D, Bühler L, Gonelle-Gispert C. Inflammatory chemokines MIP-1delta and MIP-3alpha are involved in the migration of multipotent mesenchymal stromal cells induced by hepatoma cells. Stem Cells and Development. 2015 May 15; https://www.sciencedirect.com/science/article/pii/S1743919115011899

Meier R, Mahou R, Meyer, J, Montanari, E, Morel P, Muller Y, Christofilopoulos P, Wandrey C, Gonelle-Gispert C, Bühler L. Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice. Journal of Hepatology. 2015 Mar;62(3):634-41. https://www.sciencedirect.com/science/article/pii/S016882781400796X?via%3Dihub

Giovannoni L, Muller Y, Lacotte S, Parnaud G, Borot S, Meier R, Lavallard V, Bédat B, Toso C, Daubeuf B, Elson G, Shang L, Morel P, Kosco-Vilbois M, Bosco D, Berney T. Enhancement of islet engraftment and achievement of long-term islet allograft survival by toll-like receptor 4 blockade. Transplantation 2015 Jan;99(1):29-35. https://bit.ly/2W7Pivp 

Meier R, Oulhaci-de Saussure W, Orci LA, Gutzwiller E, Morel P, Ris F, Schwenter F. Clinical Outcome in Acute Small Bowel Obstruction after Surgical or Conservative Management. World J Surg. 2014 Dec;38(12):3082-8. https://bit.ly/2W7Pivp 

Meier R, Sert I, Morel P, Muller YD, Borot S, Badet L, Toso C, Bosco D, Berney T. Islet of Langerhans isolation from pediatric and juvenile donor pancreases. Transpl Int. 2014 May 29. https://onlinelibrary.wiley.com/doi/full/10.1111/tri.12367

Meier R, Seebach JD, Morel P, Mahou R, Borot S, Giovannoni L, Parnaud G, Montanari E, Bosco D, Wandrey C, Berney T, Bühler LH, Muller YD. Survival of free and encapsulated human and rat islet xenografts transplanted into the mouse bone marrow. PLoS One. 2014 Mar 13;9(3):e91268. eCollection 2014https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091268

Mahou R, Meier R, Bühler L, Wandrey C. Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation. Materials 2014, 7(1), 275-286. https://www.mdpi.com/1996-1944/7/1/275

Orci LA, Meier R, Morel P, Staszewicz W, Toso C. Systematic review and meta-analysis of percutaneous subclavian vein puncture versus surgical venous cutdown for the insertion of a totally implantable venous access device. Br J Surg. 2013 Nov 26. https://onlinelibrary.wiley.com/doi/abs/10.1002/bjs.9276

Borot S, Crowe LA, Parnaud G, Ris F, Meier R, Giovannoni L, Müller YD, Lacotte S, Morel P, Toso C, Bosco D, Vallee JP, Berney T. Quantification of Islet Loss and Graft Functionality During Immune Rejection by 3-Tesla MRI in a Rat Model. Transplantation 2013 Jul 30. https://bit.ly/2W941G6 

Meier R, Muller YD, Morel P, Gonelle-Gispert C, Bühler LH. Transplantation of mesenchymal stem cells for the treatment of liver diseases, is there enough evidence? Stem Cell Research, 2013 Nov;11(3):1348-64. https://www.sciencedirect.com/science/article/pii/S1873506113001220?via%3Dihub

Mahou R, Kollarikova G, Gonelle-Gispert C, Meier R, Schmitt F, Tran N, Dufresne M, Lacik I, Bühler L, Juillerat-Jeanneret L, Legallais C, Christine Wandrey C. Combined Electrostatic and Covalent Polymer Networks for Cell Microencapsulation. Macromolecular Symposia July 2013; https://onlinelibrary.wiley.com/doi/full/10.1002/masy.201200099

Muller YD, Meier R, Bromberg JS, Bühler LH. Literature Watch: implications for transplantation; Blastocyst Complementation for Chimeras for Xenotransplantation. Am J Transplant. 2013 Jun;13(6):1377. https://onlinelibrary.wiley.com/doi/full/10.1111/ajt.12322

Meier R, Rizzoli R, Peter RE. Are bisphosphonates associated with an increased risk of atypical femoral fractures as a class?-Reply. JAMA Intern Med. 2013 Jan 14;173(1):80. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1557294

Meier R, Lorenzini KI, Uebelhart B, Stern R, Peter RE, Rizzoli R. Atypical femoral fracture following bisphosphonate treatment in a woman with osteogenesis imperfecta-a case report. Acta Orthop. 2012 Sep 24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488185/

Meier R, Perneger TV, Stern R, Rizzoli R, Peter RE. Increasing Occurrence of Atypical Femoral Fractures Associated With Bisphosphonate Use. Arch Intern Med. 2012 Jun 25;172(12):930-6. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1160667

Parnaud G, Gonelle-Gispert C, Morel P, Giovannoni L, Muller YD, Meier R, Borot S, Berney T, Bosco D. Cadherin Engagement Protects Human beta-Cells from Apoptosis. Endocrinology 2011 Oct 11. https://academic.oup.com/endo/article/152/12/4601/2457333

Lorenzo PI, Jimenez Moreno CM, Delgado I, Cobo-Vuilleumier N, Meier R, Gomez-Izquierdo L, Berney T, Garcia-Carbonero R, Rojas A, Gauthier BR. Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors. Histochem Cell Biol. 2011 Sep 20. https://link.springer.com/article/10.1007%2Fs00418-011-0866-3

Borot S, Niclauss N, Wojtusciszyn A, Brault C, Demuylder-Mischler S, Müller Y, Giovannoni L, Parnaud G, Meier R, Badet L, Bayle F, Frimat L, Kessler L, Morelon E, Penfornis A, Thivolet C, Toso C, Morel P, Bosco D, Colin C, Benhamou PY, Berney T; on behalf of the GRAGIL Network.  Impact of the Number of Infusions on 2-Year Results of Islet-After-Kidney Transplantation in the GRAGIL Network. Transplantation 2011 Sep 16. https://bit.ly/2AOoVTE 

Muller YD, Golshayan D, Ehirchiou D, Wyss JC, Giovannoni L, Meier R, Serre-Beinier V, Puga Yung G, Morel P, Bühler LH, Seebach JD. Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells. Diabetes 2011 Sep;60(9):2331-40. http://diabetes.diabetesjournals.org/content/60/9/2331.long

Ris F, Niclauss N, Morel P, Demuylder-Mischler S, Muller Y, Meier R, Genevay M, Bosco D, Berney T. Islet autotransplantation after extended pancreatectomy for focal benign disease of the pancreas. Transplantation 2011 Apr 27;91(8):895-901. https://bit.ly/2DpBfKW 

Niclauss N, Bosco D, Morel P, Demuylder-Mischler S, Brault C, Milliat-Guittard L, Colin C, Parnaud G, Muller YD, Giovannoni L, Meier R, Toso C, Badet L, Benhamou PY, Berney T. Influence of donor age on islet isolation and transplantation outcome. Transplantation 2011 Feb 15;91(3):360-6. https://bit.ly/2Cq1osC 

Meier R, Toso C, Volonte F, Mentha G. Splenic rupture after a colonoscopy. Am J Emerg Med. 2011 Feb;29(2):241.e1-2. https://www.ajemjournal.com/article/S0735-6757(10)00112-9/abstract

Awards and Affiliations

AWARDS 

2018: Swiss Association for Laparoscopic and Thoracoscopic Surgery; Zollikofer Award https://swiss-mis.ch/research-support/#zollikofer-awards 

2015: International Pancreas and Islet Transplant Association (IPITA); Derek Gray Distinguished Traveling Scholarship Award https://tts.org/73-ipita/ipita-about/ipita-about-awards-and-grants/102-ipita-derek-gray-award

2015: University Hospital of Geneva; Gilles Mentha Award, Basic Sciences

2015: University Hospital of Geneva; Marc-Claude Marti Award

2014: Geneva University and Medical School; Geneva University best MD-PHD thesis award (Arditi award) https://www.unige.ch/medecine/files/6714/5613/9905/Prog2014_final.pdf

 

AFFILIATIONS

Since 2020:            American Society of Transplant Surgeons (ASTS)

Since 2020:            International Hepato-Pancreato-Biliary Association (IHPBA)

Since 2018:            International Liver Transplantation Society (ILTS)

Since 2017:            Swiss Society for Surgery (SSC- SGC)

Since 2015:            Swiss Society for Visceral Surgery (SSVC) - Junior committee member

Since 2015:            Association for Research in Surgery (ARS-SGC) - Treasurer

Since 2014:            International Pancreas and Islet Transplant Association (IPITA) - Young investigator committee member

Since 2011:            European Society for Organ Transplantation (ESOT)

Since 2011:            The Transplant Society (TTS)

Since 2011:            Swiss MD-PhD Association (SMPA)

Grants and Contracts

GRANTS

Meier R (PI)« Genetic determinants of glucose homeostasis in pancreas donors». Diabetes Research Connection Grant.

Meier R (PI), «Mesenchymal stem cells for the treatment of steatohepatitis-induced liver failure». Bridge to academic career, Swiss Association for Research in Surgery. BRIDGE-2017. From 06/01/2017 to 02/28/2020.

Meier R (PI), Sophie Clément. « Human mesenchymal stem cells for the treatment of alcoholic hepatitis ».  Private Foundation of the Geneva University Hospitals and the University of Geneva's Faculty of Medicine. STARTER-RS1-18. From 05/10/2016 to 05/10/2019.

Meier R (PI), Berney T. « Genetic determinants of metabolic syndrome components in pancreas donors for islet transplantation ». Geneva University Hospitals. PRD 22-2013-I. From 05/07/2013 to 02/28/2020.

Meier R (PI), Rizzoli R. « Risk factors for atypical femur fracture during bisphosphonate therapy ». Geneva University Hospitals. PRD 9-I-2012 -EC 12-084. From 05/03/2012 to 12/15/2017.