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Paul A. Welling, MD

Academic Title:

Professor

Primary Appointment:

Physiology

Additional Title:

Director, Maryland Center for Kidney Discovery

Location:

655 West Baltimore St., BRB 5-029

Phone (Primary):

410-706-3851

Fax:

410-706-8341

Education and Training

  • 1988: M.D., University of Kansas Medical School
  • 1988-93: Fellow, Yale University Medical School, Cell and Molecular Physiology
  • 1993-99: Assistant Professor, University of Maryland Medical School
  • 1999-2001: Established Investigator, American Heart Association
  • 1999-2006: Associate Professor, University of Maryland Medical School
  • 2003: Fellow of the American Heart Association
  • 2006-present: Professor, University of Maryland Medical School
  • 2010: Teacher of the Year, Graduate Program in Life Sciences, University of MD
  • 2011: Arthur Guyton Distinguished Lectureship, Association of Chairs of Departments of Physiology
  • 2013: Fred Samsom Memorial Lecturer, University of Kansas Medical School
  • 2014: Steven Hebert Distinguished Lectureship, American Physiological Society
  • 2014: Fellow, American Association for the Advancement of Science (Elected)
  • 2015-17: Secretary, Salt and Water Club (Elected)
  • 2017: Carl W. Gottschalk Distinguished Lectureship, American Physiological Society
  • 2017: Berliner Distinguished Lectureship, Yale University Medical School
  • 2015-18: Chair, Epithelial Transport Group, American Physiological Society (Elected)

Lab Web Page

Highlighted Publications

Yoo D, Fang L, Mason A, Kim BY and Welling PA. A phosphorylation-dependent export structure in ROMK (KIR 1.1) channel overrides an ER- localization signal. J Biol Chem. 2005;280(42):35281-9.

Wade JB*, Fang L*, Liu J*, Li D*, Yang CL†, Subramanya AR†, Maouyo D*, Mason A*, Ellison DE†, and Welling PA* WNK1 Kinase Isoform Switch Regulates Renal Potassium Excretion, Proc. Natl. Acad. Sci. USA, 2006. 30;103(22):8558-63. PMCID: PMC1482529

Fang L, Garuti R, Kim BY, Wade JB, Welling PA. The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. J Clin Invest. 2009 Nov;119(11):3278-89.  PMCID: PMC2769171

Donghui M, Taneg, TK, Kim BY, Hagen B, Lederer WJ , Welling PA. Golgi Export of the Kir2.1 Channel is Driven by a Trafficking Signal Located within its the Tertiary StructureCell. 2011 Jun 24;145(7):1102-15. PMCID: PMC3139129

Grimm PR, Wall SM, Delpire E, Wade JB, Welling PA. Integrated compensatory network is activated in absence of NCC phosphorylationJ. Clin Invest 2015 May 1;125(5):2136-50. PMCID: PMC4463200

Welling PA. Roles and Regulation of Renal K Channels. Annu Rev Physiol. 2016;78:415-35.

Li X, Ortega B, Kim B, Welling PA.  A Common Signal Patch Drives AP-1 Protein-dependent Golgi Export of Inwardly Rectifying Potassium Channels.  J Biol Chem. 2016 Jul 15;291(29):14963-72.  Epub 2016 May 23.  PMID: 27226616

Grimm PR, Coleman R, Delpire E, Welling PA. Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules. J Am Soc Nephrol. 2017 Apr 25. [Epub ahead of print].  PMCID: PMC5576927

Additional Publication Citations

Research Interests

Dr. Welling is leading expert on the molecular mechanisms of renal electrolyte balance and blood pressure control. His laboratory is recognized for elucidating how ion transport molecules in the kidney control potassium and sodium balance, and for discovering how these molecules go awry in disorders of salt regulation and blood pressure. His laboratory employs a multidisciplinary approach that includes gene discovery, genomic approaches, in vitro models, genetically engineered mouse models and translational studies in humans. Click to wellinglab.com to find out more.

Research Topics

  • Molecular and Cell Biology of Kidney Physiology and Disease
  • Regulation of Salt Balance and Blood Pressure
  • Gene-diet interactions in Hypertension
  • Ion Channels and Transporters
  • Molecular Mechanisms of Trafficking Defects in Disease
  • Molecular Genetics of Membrane Transport and Excitability Disorders
  • Signal Transduction Mechanisms
  • Electrolyte Disorders
  • Diuretics

Featured Video

Video: Paul Welling talks about why we evolved to crave salt, and why that’s now unhealthy.