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John B. Sacci, PhD

Academic Title:

Associate Professor

Primary Appointment:

Microbiology and Immunology

Location:

HSF II, 435

Phone (Primary):

(410) 706-4071

Education and Training

Bates College, BA, Biology, 1978

University of Maryland, Baltimore, PhD, Pathology, 1989

Johns Hopkins School of Hygiene and Public Health, Department of Immunology and Infectious Diseases, Post-doctoral Fellow, 1990

University of Maryland School of Medicine, Department of Microbiology and Immunology, Post-doctoral Fellow, 1992

Highlighted Publications

Sacci Jr., J.B., J.C. Aguiar, A.O. Lau, S.L. Hoffman. 2002. Laser capture microdissection and molecular analysis of Plasmodium yoelii liver-stage parasites. Mol. Biochem. Parasitol. 119:285-289.

Hoffman, S.L., L.M. Goh, T.C. Luke, I. Schneider, T.P. Le, D.L. Doolan, J. Sacci, P. de La Vega, M. Dowler, C. Paul, D.M. Gordon, J.A. Stoute, L.W. Church, M. Sedegah, D.G. Heppner, W.R. Ballou, T.L. Richie. 2002. Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites. J. Infect. Dis. 185(8):1155-1164.

Sacci Jr., J.B., A.F. Azad. 2002. Gene expression analysis during liver stage development of Plasmodium. Int. J. Parasitol. 32(13):1551-1557.

Florens, L., M.P. Washburn, J.D. Raine, R.M. Anthony, M. Grainger, J.D. Haynes, J.K. Moch, N. Muster, J.B. Sacci, D.L. Tabb, A.A.Witney, D. Wolters, Y, Wu, M.J. Gardner, A.A. Holder, R.E. Sinden, J.R. Yates, D.J. Carucci. 2002. A proteomic view of the Plasmodium falciparum life cycle. Nature. 419(6906):520-526.

Sacci J.B. Jr, J.M. Ribeiro, F. Huang, U. Alam, J.A. Russell, P.L. Blair, A. Witney, D.L. Carucci, A.F. Azad, J.C. Aguiar. 2005. Transcriptional analysis of in vivo Plasmodium yoelii liver stage gene expression. Mol. Biochem. Parasitol. 142:177-83.

Sacci J.B. Jr., U. Alam, D. Douglas, J. Lewis, D.L.J. Tyrrell, A.F. Azad N.K. Kneteman. 2006. Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers. Int. J. Parasitol. 36:353-60.

Chakravarty S., I.A. Cockbun, S. KUK, M.G. Overstreet, J.B. Sacci, F. Zavala. 2007. CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat. Med. 13:1035-41.

Noe, A, D. Espinosa, X. Li, J. G. A. Coelho-dos-Reis, R. Funakoshi, S. Giardina, H. Jin, D.M. Retallack, R. Haverstock, J.R. Allen, T.S. Vedvick, C.B. Fox, S.G. Reed, R. Ayala, B. Roberts, S.B. Winram, J. Sacci, M. Tsuji, F. Zavala, G.M. Gutierrez. 2014. A full-length Plasmodium falciparum recombinant circumsporozoite protein expressed by Pseudomonas fluorescens platform as a malaria vaccine candidate. PLoS One 9(9): e107764.  PMID: 25247295

Aguiar, J.C., J. Bolton, J. Wanga, J.B. Sacci, H. Iriko, J.K. Mazeika, E.T. Han, K. Limbach, N.B. Patterson, M. Sedegah, A.M. Cruz, T. Tsuboi, S.L. Hoffman, D. Carucci, M.R. Hollingdale, E.D. Villasante, T.L. Richie. 2015. Discovery of novel Plasmodium falciparum pre-erythrocytic antigens for vaccine development. PLoS One 10(8): e0136109. PMID: 26292257

Voss, C., K. Ehrenman, G. Mlambo, S. Mishra, K.A. Kumar, J.B. Sacci Jr, P. Sinnis, I. Coppens. 2016. Overexpression of Plasmodium berghei ATG8 by liver forms leads to cumulative defects in organelle dynamics and to generation of noninfectious merozoites. mBio 7: e00682-16. PMID: 27353755.

 

Research Interests

The principle area of my research has been the study of protozoan parasites and how they interact with their respective hosts. Currently, I have research projects underway to investigate several aspects of the liver stage of Plasmodial parasites. The liver has been demonstrated to be a target for the host's immune response, yet the exact antigenic targets have not been clearly defined. I am interested in identifying antigens that may be respon-sible for the induction of a protective immune response. Additionally, the mechanisms that are utilized to protect the host are being studied. Both Plasmodium yoelii and Plasmodium falciparum are being used to study these molecular and immunological events that accompany infection of hepatocytes.