Education and Training
Dr. Mathur received his B.A (Neuroscience) from Oberlin College in 1998 where he performed honors research on comparative neuroanatomy with Mark Braford, Ph.D. He subsequently worked for four years at Lexicon Pharmaceuticals Inc., in The Woodlands, TX as a research associate performing molecular biology/genetics research. Dr. Mathur received his Ph.D. (Neuroscience) in 2008 from Vanderbilt University under the mentorship of Ariel Y. Deutch, Ph.D. and did postdoctoral research at the National Institute of Alcohol Abuse and Alcoholism at the National Institutes of Health in Rockville, MD in the laboratory of David M. Lovinger, Ph.D. Dr. Mathur joined the faculty at the University of Maryland School of Medicine in the Department of Pharmacology in 2013.
The primary focus of the lab is to understand how neural macro- and microcircuits control action learning and selection under normal and pathophysiological conditions. We combine neuroanatomical methods with genetic, optogenetic, in vivo calcium imaging, animal behavior, fast-scan cyclic voltammetry, and slice electrophysiology to define both neural circuit form and function. We employ mouse models of Parkinson's disease and alcohol drinking paradigms to determine how specific neural circuits are affected by these pathological states with a focus on restoring normal circuit function and, therefore, behavior.
Systems neuroscience Attentional control of action learning and control Addiction research Alcohol abuse and alcoholism Parkinson's disease Movement disorders Striatum Claustrum
White MG, Panicker M, Mu C, Carter AM, Roberts BM, Dharmasri PA, Mathur BN. (2018) Anterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Control. Cell Rep. Jan 2;22(1):84-95.
White MG, Cody PA, Bubser M, Wang HD, Deutch AY and Mathur BN (2017), Cortical hierarchy governs rat claustrocortical circuit organization. J. Comp. Neurol. doi:10.1002/cne.23970
Patton MH, Roberts BM, Lovinger DM, Mathur BN. (2016) Ethanol Disinhibits Dorsolateral Striatal Medium Spiny Neurons Through Activation of A Presynaptic Delta Opioid Receptor. Neuropsychopharmacology. Jun;41(7):1831-40.
Atwood BK, Lovinger DM, Mathur BN. (2014) Presynaptic long-term depression mediated by Gi/o-coupled receptors. Trends Neurosci. Nov;37(11):663-73.
Mathur BN, Tanahira C, Tamamaki N, Lovinger DM (2013) Voltage drives diverse endocannabinoid signals to mediate striatal microcircuit-specific plasticity. Nat Neurosci. Sep;16(9):1275-83.
Mathur BN, Capik NA, Alvarez VA, Lovinger DM. (2011) Serotonin induces long-term depression at corticostriatal synapses. J Neurosci. May 18;31(20):7402-11.
White MG, Mathur BN. (2018) Claustrum circuit components for top-down input processing and cortical broadcast. Aug 14, Brain Struct Funct.
Cover KK, Kerkhoff WG, Mathur BN. (2018) The best defense is a strong offense: preventing alcohol abstinence-induced depression. Neuropsychopharmacology. Jul 30.
Licheri V, Lagström O, Lotfi A, Patton MH, Wigström H, Mathur BN, Adermark L. Complex Control of Striatal Neurotransmission by Nicotinic Acetylcholine Receptors via Excitatory Inputs onto Medium Spiny Neurons. J Neurosci. 2018 Jul 18;38(29):6597-6607.
Wenzel JM, Oleson EB, Gove WN, Cole AB, Gyawali U, Dantrassy HM, Bluett RJ, Dryanovski DI, Stuber GD, Deisseroth K, Mathur BN, Patel S, Lupica CR, Cheer JF. (2018) Phasic Dopamine Signals in the Nucleus Accumbens that Cause Active Avoidance Require Endocannabinoid Mobilization in the Midbrain. Curr Biol. May 7;28(9):1392-1404.e5.
White MG, Mathur BN. (2018) Frontal cortical control of posterior sensory and association cortices through the claustrum. Brain Struct Funct. Jul;223(6):2999-3006.
Chandra R, Engeln M, Schiefer C, Patton MH, Martin JA, Werner CT, Riggs LM, Francis TC, McGlincy M, Evans B, Nam H, Das S, Girven K, Konkalmatt P, Gancarz AM, Golden SA, Iñiguez SD, Russo SJ, Turecki G, Mathur BN, Creed M, Dietz DM, Lobo MK. (2018) Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence. Neuron. Dec 20;96(6):1327-1341.e6
Brown SP, Mathur BN, Olsen SR, Luppi PH, Bickford ME, Citri A. New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum. (2017) J Neurosci. Nov 8;37(45):10877-10881.
Roberts BM, Jarrin SE, Mathur BN, Bailey AM. (2016) Illuminating the undergraduate behavioral neuroscience laboratory: A guide for the in vivo application of optogenetics in mammalian model organisms. J Undergrad Neurosci Educ. Apr 15;14(2):A111-6.
Lovinger DM, Mathur BN. (2016) Endocannabinoid Signaling in the Striatum in Handbook of Basal Ganglia Structure and Function 2nd ed. Steiner H, Tseng KY, editors. Amsterdam: Elsevier\
Patton MH, Shah AP, Mathur BN. (2016) Alcohol Effects on the Dorsal Striatum. in The Basal Ganglia-Novel Perspectives on Motor and Cognitive Functions Soghomonian J, editor. New York : Springer.
Deutch AY, Mathur BN. (2015) Editorial: The Claustrum: charting a way forward for the brain's most mysterious nucleus. Front Syst Neurosci. Jul 15;9: 103.
Mathur BN (2015) High on 'chronic': an unexpected route to cannabinoid-induced synaptic plasticity. J Physiol. Feb 15;593(4):759-60.
Mathur BN. (2014) The claustrum in review. Front Syst Neurosci. Apr 4;8:48.
Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG. (2012) Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS One.7(9):e45323.
Cachope R, Mateo Y, Mathur BN, Irving J, Wang HL, Morales M, Lovinger DM, Cheer JF. (2012) Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell Rep. 2012 Jul 26;2(1):33-41.
Mathur BN, Lovinger DM. (2012) Endocannabinoid-dopamine interactions in striatal synaptic plasticity. Front Pharmacol. Apr 19;3:66.
Lovinger DM, Mathur BN. Endocannabinoids in striatal plasticity. (2012) Parkinsonism Relat Disord. Jan;18 Suppl 1:S132-4.
Mathur BN, Lovinger DM. Serotonergic action on dorsal striatal function. Parkinsonism Relat Disord. (2012) Jan;18 Suppl 1:S129-31.
Cuzon Carlson VC, Mathur BN Davis MI, Lovinger DM. (2011) Subsets of Spiny Striosomal Striatal Neurons Revealed in the Gad1-GFP BAC Transgenic Mouse. Basal Ganglia. Nov 1;1(4):201-211.
Torres-Altoro MI, Mathur BN, Drerup JM, Thomas R, Lovinger DM, O'Callaghan JP, Bibb JA. (2011) Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum. J Neurochem. Oct;119(2):303-13.
Mathur BN, Caprioli RM, Deutch AY. (2009) Proteomic analysis illuminates a novel structural definition of the claustrum and insula. Cereb Cortex. Oct;19(10):2372-9.
Mathur BN, Neely MD, Dyllick-Brenzinger M, Tandon A, Deutch AY. (2007) Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration. Brain Res. Sep 7;1168:83-9.
Mathur BN, Deutch AY. (2008) Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3. Neurosci Lett. Apr 18;435(2):90-4.
Mathur BN, Neely MD, Dyllick-Brenzinger M, Tandon A, Deutch AY. (2007) Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration. Brain Res. 2007 Sep 7;1168:83-9.
Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt M, Gupta A, Ramirez-Solis R, Zambrowicz BP, Powell DR. (2001) Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol. Jul;21(14):4829-36.
Maor MH, Dubey P, Tucker SL, Shiu AS, Mathur BN, Sawaya R, Lang FF, Hassenbusch SJ. Stereotactic radiosurgery for brain metastases: results and prognostic factors. Int J Cancer. 2000 Jun 20;90(3):157-62.
We take a synapse to behavior approach to defining neural circuits for the following projects:
Native dorsal and ventral striatal inhibitory synaptic plasticity mechanisms and their control by alcohol
Thalamostriatal circuitry in local control of dorsal striatal dopamine release
Striatal fast-spiking interneuron encoding of actions
The role of the claustrum
NIAAA/NIH 1R01 AA024845
Whole-cell patch clamp electrophysiology
Fast scan cyclic voltammetry
In vivo and ex vivo optogenetics
In vivo and ex vivo chemogenetics
In vivo calcium imaging using miniature fluorescence microscopes
In vivo time-correlated single photon counting monitoring of circuit function (fiber photometry)
Animal behavior (operant behavior, alcohol drinking, motor function assays)