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Xiaofeng Jia, BM, PhD

Academic Title:

Associate Professor

Primary Appointment:

Neurosurgery

Secondary Appointment(s):

Anatomy Neurobiology, Orthopaedics

Location:

MSTF, 5-59, 5-59A

Phone (Primary):

410-706-5026

Phone (Secondary):

410-706-5025

Education and Training

M.D., Clinical Medicine, Zhengjiang Medical University, 1994
M.S., Surgery, Shanghai Medical University, 1997
Ph.D., Surgery (Orthopaedics), Fudan University, 2003
Post-doctoral training, Biomedical Engineering, Johns Hopkins University, 2004-2007

Biosketch

Xiaofeng Jia, B.M., M.S., Ph.D. is an associate professor of the Department of Neurosurgery at the University of Maryland School of Medicine, Orthopaedics, and an adjunct associate professor of the Department of Biomedical Engineering and Anesthesiology & Critical Care Medicine at Johns Hopkins University School of Medicine. He has been a Faculty since 2007 and was the Associate Research Professor in the Department of Biomedical Engineering, Physical Medicine and Rehabilitation, Anesthesiology & Critical Care Medicine at Johns Hopkins University. He completed his surgery residency in the Huashan Hospital and Orthopedic Surgery fellowship in the Shanghai 6th People's Hospital. He had been an Attending Surgeon in the Department of Orthopedics at the Shanghai 6th People's Hospital and later the Zhongshan Hospital.

 

Dr. Jia is a Chartered member of NIH study section for Acute Neural Injury and Epilepsy study section [ANIE]and has been serving as an adhoc member of NIH study sections for ZRG1 BDCN-K Member Conflict Special Emphasis Panel [Brain Disorders and Clinical Neuroscience Integrated Review Group]; ZRG1 CFS-N (80) S Member Conflict Special Emphasis Panel; Clinical Neuroplasticity and Neurotransmitters [CNNT]; Biomaterials & Biointerfaces [BMBI]; Acute Neural Injury and Epilepsy [ANIE]; Brain Injury and Neurovascular Pathologies [BINP]; and ETTN-10 Clinical Neurophysiology, Devices, Neuroprosthetics and Biosensors Small Business Panel. He has been the invited ad hoc reviewer for the EUROPEAN COMMISSION Research Executive Agency (REA); United Kingdom Medical Research Council; Hong Kong Research Grants Council; American Heart Association; Society of Critical Care Medicine; United Kingdom National Institute of Academic Anaesthesia (NIAA) et al. He is the Editor in Chief of International Journal of Molecular Sciences, a member of eight editorial boards of international SCI journals and the guest editors for the Special issues for the International Journal of Molecular Sciences and BioMed Research International. He is Adhoc Peer Reviewer of 30+ international SCI journals. Dr. JIA is an elected member (basic science) of the American Academy of Orthopaedic Surgeons (AAOS), elected full member of American Association for Hand Surgery (AAHS), appointed Scientific Review committee member and Research Section Steering Committee member, of Society of Critical Care Medicine (SCCM) et al.

Research/Clinical Keywords

Brain monitoring and therapeutic hypothermia; peripheral nerve injury and regeneration; bone regeneration; and stem cell therapy

Highlighted Publications

  • Cui D, Shang H, Young L, Zhang X, Jiang W, Jia X*. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific Reports. 2016 6:27642 DOI: 10.1038/srep27642 PMID: 27273382

  • Johnson BN, Lancaster KZ, Zhen G, He J, Gupta MK, Kong YL, Engel EA, Krick KD, Ju A, Meng F, Enquist LW, Jia X*, McAlpine MC*. 3D Printed Nerve Regeneration Pathways. Advanced Functional Materials  2015 October 21; 25 (39): 6205–6217. [Epub 2015 SEP 18], PMID: 26924958 (* indicate Co-corresponding authors) Highlighted in NIH Research Matters and NIH 2015 Research Highlights

  • Zhen G, Wen C, Jia X, Li Y, Crane JL, Mears SC, Askin FB, Frassica FJ, Chang W, Yao J, Carrino JA, Cosgarea A, Artemov D, Chen Q, Zhao Z, Zhou X, Riley L, Sponseller P, Wan M, Lu WW, Cao X. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nature Medicine 2013 Jun;19(6):704-12. doi: 10.1038/nm.3143. Epub 2013 May 19. PMID: 23685840 Highlighted in [Editorials] by Bush JR, Beier F. TGF-β and osteoarthritis--the good and the bad. Nat Med. 2013 Jun;19(6):667-9. doi: 10.1038/nm.3228, and in Nat Rev Rheumatol by Leah E. Osteoarthritis: TGF-β overload at bones of cartilage degeneration. 2013 Jul;9(7):382. doi: 10.1038/nrrheum.2013.81. Epub 2013 May 28.

  • Lewitus D, Vogelstein J, Zhen G, Choi YS, Kohn J, Harshbarger S, Jia X*. Designing Tyrosine-derived Polycarbonate Polymers for Biodegradable Regenerative Type Neural Interface Capable of Neural Recording. IEEE Trans Neural Syst Rehabil Eng. 2011 Apr;19(2):204-12. Epub 2010 Dec 10. PMID: 21147598

  • Madhok J, Maybhate A, Xiong W, Geocadin RG, Jia X*, Thakor NV*. Quantitative Assessment of Somatosensory Evoked Potentials after Cardiac Arrest in Rats: Prognostication of Functional Outcomes. Critical Care Medicine 2010 Aug;38(8):1709-17. Epub 2010 Jun 3 PMID: 20526197 Highlighted in [Editorials] by Young GB. Promising prognostic potentials: perhaps. Crit Care Med. 2010 Aug;38(8):1753. doi: 10.1097/CCM.0b013e3181e8788c. (* indicate Co-corresponding authors)

  • Jia X, Ji JH, Petersen S, Freehill MT, McFarland EG. An Analysis of Shoulder Laxity in Patients Undergoing Shoulder Surgery. The Journal of Bone and Joint Surgery (AM) 2009 Sep;91(9):2144-50 PMID: 19723991

  • Jia X*, Koenig MA, Nickl R, Zhen G, Thakor NV, Geocadin RG. Early Electrophysiologic Markers Predict Functional Outcome Associated with Temperature Manipulation after Cardiac Arrest in Rats. Critical Care Medicine 2008; 36 (6):1909-16 PMID: 18496359 Highlighted in [Editorials] by Tempelhoff, René MD; Yoder, Jeffrey MD. Monitoring the brain: Lack of tools or lack of will? Critical Care Medicine 2008; 36 (6):1983-1984

  • Jia X*, Koenig MA, Zhang X, Zhang J, Chen T, Chen Z. Residual Motor Signal In Long-Term Human Severed Peripheral Nerves And Feasibility Of Neural Signal-Controlled Artificial Limb. The Journal of Hand Surgery (AM). 2007 May-June, 32(5), 657-666 PMID: 17482005

Additional Publication Citations

Selected since 2006

  1. Jiang L, Jones S, Jia X*. Stem cell transplantation for peripheral nerve regeneration: Current options and opportunities. Int J Mol Sci. 2017 Jan 5;18(1). pii: E94. doi: 10.3390/ijms18010094. PMID: 28067783
  2. Jones S, Schwartzbauer G, Jia X*. Brain Monitoring in Critically Neurologically Impaired Patients. Int J Mol Sci. 2016 Dec 27;18(1). pii: E43. doi: 10.3390/ijms18010043 PMID: 28035993
  3. Jia X*. Translational Medicine: Creating the Crucial Bidirectional Bridge between Bench and Bedside. Int. J. Mol. Sci. 2016, Nov 16;17(11). pii: E1918; doi: 10.3390/ijms17111918 PMID: 27854337
  4. Johnson BN and Jia X*. 3D Printed Nerve Guidance Channels: Computer-aided Control of Geometry, Physical Cues, Biological Supplements and Gradients. Neural Regen Res. 2016 Oct;11(10):1568-1569. PMID: 27904481
  5. Jones S, Eisenberg HM, Jia X*. Advances and future application of augmented peripheral nerve regeneration. Int J Mol Sci. 2016 Sep 7;17(9). pii: E1494; doi:10.3390/ijms17091494 PMID: 27618010
  6. Cui D, Shang H, Young L, Zhang X, Jiang W, Jia X*. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific Reports. 2016 6:27642 DOI: 10.1038/srep27642 PMID: 27273382
  7. Choi YS*, Jia X*. Information-theoretical Quantifier of Brain Rhythm Based on Data-driven Multiscale Representation. Biomed Research International. 2015;2015:946201. Epub 2015 Nov 12. PMID: 26640802
  8. Deng R,  Xiong W, Jia X*. Electrophysiological Monitoring of Brain Injury and Recovery after Cardiac Arrest. Int J Mol Sci. 2015 Oct 30;16(11):25999-6018. doi: 10.3390/ijms161125938 PMID: 26528970
  9. Johnson BN, Lancaster KZ, Zhen G, He J, Gupta MK, Kong YL, Engel EA, Krick KD, Ju A, Meng F, Enquist LW, Jia X*, McAlpine MC*. 3D Printed Nerve Regeneration Pathways. Advanced Functional Materials  2015 October 21; 25 (39): 6205–6217. [Epub 2015 SEP 18], PMID: 26924958 (* indicate Co-corresponding authors) Highlighted in NIH Research Matters and NIH 2015 Research Highlights
  10. Karapetkova M, Koenig MA, Jia X*. Early Prognostication Markers in Cardiac Arrest Patients Treated with Hypothermia. European Journal of Neurology. 2016 Mar;23(3):476-88. doi: 10.1111/ene.12803. Epub 2015 Jul 31. PMID: 26228521
  11. Deng R, Koenig MA, Young LM, Jia X*. Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes after Cardiac Arrest and Targeted Temperature Management. Neurocritical Care. 2015 Oct;23(2):262-73. doi: 10.1007/s12028-015-0157-2. [Epub 2015 Jul 1]  PMID: 26130405
  12. Jia X *, Romero-Ortega MI, Teng YD. Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies. BioMed Research International. 2014;2014:145304. doi: 10.1155/2014/145304. Epub 2014 Dec 23 PMID: 25587530
  13. Xiong W, Jia X*.Is Neurologic Prognostication After Hypothermia Ready for Primetime? Critical Care Medicine. 2014, Dec;42(12):2644-2645. PMID: 25402291
  14. Hutton DL, Kondragunta R, Moore EM, Hung BP, Jia X, Grayson WL. Tumor Necrosis Factor Improves Vascularization in Osteogenic Grafts Engineered with Human Adipose-Derived Stem/Stromal Cells. PLoS One. 2014 Sep 23;9(9):e107199. doi: 10.1371/journal.pone.0107199. eCollection 2014. PMID: 25248109
  15. Temple JP, Hutton DL, Hung BP, Huri PY, Cook CA, R Kondragunta, Jia X, Grayson WL. Engineering Anatomically Shaped Vascularized Bone Grafts with hASCs and 3D-Printed PCL Scaffolds. J Biomed Mater Res A. 2014 Dec;102(12):4317-25. doi: 10.1002/jbm.a.35107. Epub 2014 Feb 19 PMID: 24510413
  16. Chen C, Maybhate A, Israel D, Thakor NV, Jia X*. Analysis of Granger Causality for Assessment of Thalamocortical Functional Connectivity. IEEE Trans Neural Syst Rehabil Eng.2013 Sep;21(5):725-33. doi: 10.1109/TNSRE.2013.2271246. Epub 2013 Jul 10 PMID: 23864221
  17. Li J, Zhen G, Tsai SY, Jia X*. Epidermal Stem Cells in Orthopaedic Regenerative Medicine. International Journal of Molecular Sciences. 2013 May 31;14(6):11626-42. doi: 10.3390/ijms140611626 PMID: 23727934
  18. Zhen G, Wen C, Jia X, Li Y, Crane JL, Mears SC, Askin FB, Frassica FJ, Chang W, Yao J, Carrino JA, Cosgarea A, Artemov D, Chen Q, Zhao Z, Zhou X, Riley L, Sponseller P, Wan M, Lu WW, Cao X. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nature Medicine 2013 Jun;19(6):704-12. doi: 10.1038/nm.3143. Epub 2013 May 19. PMID: 23685840 Highlighted in [Editorials] by Bush JR, Beier F. TGF-β and osteoarthritis--the good and the bad. Nat Med. 2013 Jun;19(6):667-9. doi: 10.1038/nm.3228, and in Nat Rev Rheumatol by Leah E. Osteoarthritis: TGF-β overload at bones of cartilage degeneration. 2013 Jul;9(7):382. doi: 10.1038/nrrheum.2013.81. Epub 2013 May 28.
  19. Nag S, Jia X, Thakor NV, Sharma D. Flexible Charge Balanced Stimulator with 5.6 fC Accuracy for 140 nC Injections. IEEE Transactions on Biomedical Circuits and Systems 2013; 7(3): 266-275 DOI:10.1109/TBCAS.2012.2205574 PMID: 23853326
  20. Liu S, Jia X, Li C, Han X, Yan W, Xing Y. CXCR7 silencing attenuates cell adaptive response to stromal cell derived factor 1α after hypoxia. PLOS ONE 2013;8(1):e55290. doi: 10.1371/journal.pone.0055290. Epub 2013 Jan 31 PMID: 23383139
  21. Jia X*, Kowalski RG, Sciubba DM, Geocadin RG. Critical Care of Traumatic Spinal Cord Injury. J Intensive Care Med. 2013 Jan-Feb;28(1):12-23. doi: 10.1177/0885066611403270. Epub 2011 Apr 11. PMID: 21482574
  22. Wan M, Li C, Zhen G, Jiao K, He W, Jia X, Wang W, Shi C, Xing Q, Chen YF, Jan De Beur S, Yu B, Cao X. Injury-Activated TGFβ Controls Mobilization of Mscs for Tissue Remodeling. Stem Cells 2012 Nov;30(11):2498-511. doi: 10.1002/stem.1208. Epub 2012 Aug 21 PMID: 22911900
  23. Kortelainen J, Jia X, Seppänen T, Thakor NV. Increased electroencephalographic gamma activity reveals awakening from isoflurane anaesthesia in rats. British Journal of Anaesthesia. 2012 Nov;109(5):782-9 doi: 10.1093/bja/aes265. Epub 2012 Aug 19 PMID: 22907339
  24. Tan EW, Ting BL, Jia X, Skolasky RL, McFarland EG. Diagnostic errors in orthopaedic surgery: evaluation of resident documentation of neurovascular examinations for orthopaedic trauma patients. Am J Med Qual 2013 Jan;28(1):60-8. doi: 10.1177/1062860612447856. Epub 2012 Jul 13. PMID: 22798636
  25. Xian L, Wu X, Pang L, Lou M, Rosen C, Qiu T, Crane J, Frassica F, Zhang L, Rodriguez JP, Jia X, Yakar S, Xuan S, Efstratiadis A, Wan M, Cao X. Matrix IGF-1 Regulates Bone Mass by Activation of mTOR in Mesenchymal Stem Cells. Nature Medicine 2012 18 (7), 1095-1101 Epub 2012 Jun 24. doi: 10.1038/nm.2793. PMID: 22729283 Highlighted in Nat Rev Rheumatol by Carney EF.Bone: modulation of IGF-1 might prevent osteoporosis. 2012 Aug;8(8):440. doi: 10.1038/nrrheum.2012.112. Epub 2012 Jul 10
  26. Zhang D, Jia X, Ding H. The effect of anesthetic concentration on burst-suppression of the EEG in rats. Journal of Biomedical Engineering (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi). 2012 Apr;29(2):223-8, 232. PMID: 22616162
  27. Madhok J, Wu D, Xiong W, Geocadin RG, Jia X*. Hypothermia amplifies somatosensory evoked potentials in uninjured rats. J Neurosurg Anesthesiol. 2012 Jul;24(3):197-202 Equb 2012 Mar 20 PMID: 22441433
  28. Wu D, Xiong W, Jia X, Geocadin RG, Thakor NV. Short- and Long-latency Somatosensory Neuronal Responses Reveal Selective Brain Injury and Effect of Hypothermia in Global Hypoxic-Ischemia. Journal of Neurophysiology 2012 Feb;107(4):1164-71. Epub 2011 Dec 7 PMID: 22157111
  29. Dewan AK, Garzon-Muvdi J, Petersen SA, Jia X, McFarland EG. Intraarticular Abnormalities in Overhead Athletes Are Variable. Clin Orthop Relat Res 2012 Jun;470(6):1552-7 Epub 2011 Nov 18 PMID: 22095131
  30. Ma Y, Hu Y, Valentin N, Geocadin R, Thakor NV, Jia X*. Time Jitter of Somatosensory Evoked Potentials in Recovery from Hypoxic-ischemic Brain Injury. Journal of Neuroscience Methods 2011 Oct 15;201(2):355-360. Epub 2011 Aug 22. PMID: 21878352
  31. Jia X*, Peters PG, Schon L. The Use of Platelet-Rich Plasma in the Management of Foot and Ankle Conditions. Operative Techniques in Sports Medicine 2011 Sept 19(3) 177-184 DOI
  32. Jia X, Yokota A, McCarty EC, Nicholson GP, Weber SC, McMahon PJ, Dunn WR, McFarland EG. Reproducibility and Reliability of the Snyder Classification of Superior Labral Anterior Posterior Lesions Among Shoulder Surgeons. Am J Sports Med 2011 May;39(5):986-91. Epub 2011 Feb 1 PMID: 21285446
  33. Lewitus D, Vogelstein J, Zhen G, Choi YS, Kohn J, Harshbarger S, Jia X*. Designing Tyrosine-derived Polycarbonate Polymers for Biodegradable Regenerative Type Neural Interface Capable of Neural Recording. IEEE Trans Neural Syst Rehabil Eng. 2011 Apr;19(2):204-12. Epub 2010 Dec 10. PMID: 21147598
  34. Wu D, Anastassios B, Xiong W, Madhok J, Jia X, Thakor NV. Study of the origins of short- and long-latency SSEP during recovery from brain ischemia in a rat model. Neuroscience Letters 2010 Nov 26;485(3):157-61. Epub 2010 Sep 21 PMID: 20816917
  35. Jia X, Ji JH, Pannirselyam VK, Petersen S, McFarland EG. Does a Positive Neer Impingement Sign Reflect Rotator Cuff Contact with the Acromion? Clin Orthop Relat Res, 2011 Mar;469(3):813-8. Epub 2010 Sep 28 PMID: 20878281
  36. Madhok J, Maybhate A, Xiong W, Geocadin RG, Jia X*, Thakor NV*. Quantitative Assessment of Somatosensory Evoked Potentials after Cardiac Arrest in Rats: Prognostication of Functional Outcomes. Critical Care Medicine 2010 Aug;38(8):1709-17. Epub 2010 Jun 3 PMID: 20526197 Highlighted in [Editorials] by Young GB. Promising prognostic potentials: perhaps. Crit Care Med. 2010 Aug;38(8):1753. doi: 10.1097/CCM.0b013e3181e8788c (* indicate Co-corresponding authors)
  37. Choi Y, Koenig MA, Jia X, Thakor NV. Quantifying Time-varying Multiunit Neural Activity using Entropy based Measures. IEEE Tran. Biomedical Eng 2010 Nov 57(11):2771-7. May 10. [Epub ahead of print] PMID: 20460201
  38. Xiong W, Koenig M, Madhok J, Jia X, Puttgen HA, Thakor NV, Geocadin RG. Evolution of Somatosensory Evoked Potentials after Cardiac Arrest Induced Hypoxic-Ischemic Injury. Resuscitation 2010 Jul;81(7):893-7. Epub 2010 Apr 24. PMID: 20418008 Highlighted in [Editorials] by Young GB. Somatosensory evoked potentials after cardiac arrest: a stimulus for investigation. Resuscitation. 2010 Jul;81(7):784-5. doi: 10.1016/j.resuscitation.2010.03.032. Epub 2010 Apr 24.
  39. McFarland EG, Garzon-Muvdi J, Jia X, Desai P, Petersen SA. Clinical and Diagnostic Tests for Shoulder Disorders: A Critical Review. British Journal of Sports Medicine 2010;44(5):328-3320 Epub 2009 Dec 2. PMID: 19955165
  40. Jia X, Petersen S, Khosravi AH, Almareddi V, Pannirselvam V, McFarland EG. Examination of the Shoulder: the Past, the Present, and the Future. The Journal of Bone and Joint Surgery (AM)  2009 91(Suppl 6):10-18 PMID: 19884407
  41. McFarland EG, Tanaka MJ, Garzon-Muvdi J, Jia X, Petersen S. Clinical and imaging assessment for superior labrum anterior and posterior lesions. Curr Sports Med Rep. 2009 Sep-Oct;8(5):234-9 PMID: 19741350
  42. Jia X, Ji JH, Petersen S, Freehill MT, McFarland EG. An Analysis of Shoulder Laxity in Patients Undergoing Shoulder Surgery. The Journal of Bone and Joint Surgery (AM) 2009 Sep;91(9):2144-50 PMID: 19723991
  43. Zhang D, Jia X, Ding H, Ye D, and Thakor NV. Application of Tsallis Entropy to EEG: Quantifying the Presence of Burst Suppression after Asphyxial Cardiac Arrest in Rats. IEEE Tran. Biomedical Eng 2010 57 (4): 867 – 874 Epub 2009 Aug 18. PMID: 19695982
  44. Kang X, Jia X, Geocadin RG, Thakor NV, Maybhate A. Multi-scale entropy analysis for assessment of post-cardiac arrest recovery under hypothermia. IEEE Tran. Biomedical Eng 2009 April 50 (4):1023-31 PMID: 19174339
  45. Koenig MA, Jia X, Kang X, Velasquez A, Thakor NV, Geocadin RG. Intraventrcular Orexin-A Improves Arousal and EEG Entropy in Rats after Cardiac Arrest. Brain Res. 2009 Feb 19;1255:153-61. Epub 2008 Dec 16.   PMID: 19111527
  46. Li N, Jia X, Murari K, Parlapalli R, Rege A, Thakor NV. High Spatiotemporal Resolution Imaging of the Neurovascular Response to Electrical Peripheral Trigeminal Nerve Stimulation as Revealed by in vivo Laser Speckle Contrast. Journal of Neuroscience Methods 2009 Jan;176(2):230-6. Epub 2008 Jul 25. PMID: 18706442
  47. Jia X, Ji JH, Petersen S, Keefer J, McFarland EG. Clinical Evaluation of the Shoulder Shrug Sign. Clin Orthop Relat Res,  2008 Nov;466(11):2813-9 PMID: 18543050
  48. Jia X*, Koenig MA, Venkatraman A, Thakor NV, Geocadin RG. Post-cardiac arrest temperature manipulation alters early EEG bursting in rats. Resuscitation 2008 Sep; 78, (3):367-373 PMID: 18597914
  49. Shin HC, Jia X, Nickl R, Geocadin RG and Thakor NV. A Subband-based Information Measure of EEG During Brain Injury and Recovery After Cardiac Arrest, IEEE Tran. Biomedical Eng 2008 Aug;55(8):1985-90PMID: 18632361 Highlighted in Journal Cover Illustration
  50. Geocadin RG, Koenig MA, Jia X, Stevens RD, Peberdy MA. Management of brain injury after resuscitation from cardiac arrest. Neurol Clin 2008 May 26 (2) 487-506 PMID: 18514823
  51. Jia X*, Koenig MA, Nickl R, Zhen G, Thakor NV, Geocadin RG. Early Electrophysiologic Markers Predict Functional Outcome Associated with Temperature Manipulation after Cardiac Arrest in Rats. Critical Care Medicine 2008; 36 (6):1909-16 PMID: 18496359 Highlighted in [Editorials] by Tempelhoff, René MD; Yoder, Jeffrey MD. Monitoring the brain: Lack of tools or lack of will? Critical Care Medicine 2008; 36 (6):1983-1984
  52. Jia X*, Zhen G, Puttgen A, Zhang J, Chen T. Improved long-term recording of nerve signal by modified intrafascicular electrodes in rabbits. Microsurgery 2008 28(3): 173-178 PMID: 18286654
  53. McFarland EG, Srikumaran U, Petersen SA, Jia X and Fayad LM. How to make sense of shoulder MRI: determining when to treat and when to refer. J Musculoskelet Med 2007 24(12):500-506
  54. Jia X*, Koenig MA, Shin HC, Zhen G, Pardo CA, Hanley DF, Thakor NV, Geocadin RG. Improving neurological outcomes post-cardiac arrest in a rat model: Immediate hypothermia and quantitative EEG monitoring. Resuscitation, 2008 March 76(3), 431-442 PMID: 17936492
  55. Murari K, Li N, Rege A, Jia X, All A, Thakor NV. Contrast Enhanced Imaging of Cerebral Vasculature with Laser Speckle. Applied Optics. 2007 Aug 1, 46(22), 5340-5346 PMID: 17676149
  56. Jia X*, Koenig MA, Zhang X, Zhang J, Chen T, Chen Z. Residual Motor Signal In Long-Term Human Severed Peripheral Nerves And Feasibility Of Neural Signal-Controlled Artificial Limb. The Journal of Hand Surgery (AM). 2007 May-June, 32(5), 657-666 PMID: 17482005
  57. Jia X*, Koenig MA, Shin HC, Zhen G, Yamashita S, Thakor NV, Geocadin RG. Quantitative EEG and Neurological Recovery after therapeutic Hypothermia of Asphyxial Cardiac Arrest in Rats. Brain Research, 2006 September 21, 1111(1) 166-175 PMID: 16919609
  58. Shin HC, Tong S, Yamashita S, Jia X, Geocadin RG, Thakor NV, Quantitative EEG and Effect of Hypothermia on Brain Recovery After Cardiac Arrest. IEEE Trans. on Biomedical Eng, 2006 Jun, 53 (6): 1016-1023 PMID: 16761828
  59. Hu T, Zhang X, Zhang Z, Zhang J, Jia X, Zheng X, Yang Y, Chen Z, Xu X, Chen T. Initial detection and analysis of neuro-information from amputee. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2006 Feb; 23(1):1-5 PMID: 16532797

Research Interests

Dr. Jia's research interests include brain monitoring and therapeutic hypothermia, peripheral nerve injury and regeneration, translational therapeutic model for neurological injuries, development and characterization of biomaterials for bone and peripheral nerve regeneration.

 

  1. Brain Monitoring and Therapeutic Hypothermia

The current research focuses on the development of novel translational tools for uncovering mechanisms of brain injury after cardiac arrest, monitoring and tracking the neurological injuries, and guiding treatments like therapeutic hypothermia.

The goal is to develop quantitative EEG based neuro-electrical markers of coma and arousal after cardiac arrest, and modulate therapeutic hypothermia by quantitative electrophysiological markers toward improved functional outcome. This project seeks to explore the impact of therapeutic hypothermia on spatio-temporal pattern of glucose utilization measured by small animal positron emission tomography (PET) imaging, and electrophysiological recovery after cardiac arrest.

 

  1. Peripheral Nerve Injury

The current research focuses on developing novel methodology to promote nerve regeneration after peripheral nerve injury and developing novel nerve scaffold for the next generation of nerve signal controlled prosthetic limbs.

This grant from supports Maryland Stem Cell Research Fund new and/or innovative hypotheses, approaches, mechanisms or models that will advance the field of regenerative medicine and generate human stem cell therapies to repair or replace missing, damaged, or diseased cells, tissues and organs. This project aims to develop potential cell based therapies for peripheral nerve injury to enhance peripheral nerve regeneration and functional recovery in a translational model.

 

  1. Bone Regeneration

The current research focuses on developing novel cell based vascularized bone grafts to promote bone regeneration for critical sized bone defect injury.

Tissue engineering approaches combined with recent advances in stem cell biology may enable the growth of bone grafts for the treatment and repair of critical-sized orthopedic defects which may arise due to trauma, infection, tumor resections or congenital abnormalities. This project aims to develop potential cell based therapies for critical sized bone defect injury to enhance bone regeneration and functional recovery in a translational model.

Awards and Affiliations

  • Highlight in NIH Research Matters and NIH 2015 Research Highlights, 2015
  • Best Abstract Presentations, 5th International Hypothermia Symposium, 2014
  • Finalist of Student Paper Competition Award at the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC), 2013 (as sponsor Faculty and corresponding author)
  • Highlight as a significant advance based on animal research at the 65th American Academy of Neurology (AAN) Annual Meeting, 2013
  • Best Presentation Winner for Clinicians in the 2nd Annual Safer Symposium in Johns Hopkins Bayview Medical Center, 2010
  • Top 20 Scientific Exhibits Award of the American Academy of Orthopaedic Surgeons (AAOS), 2009
  • Finalist of the Best Overall Poster Award of American Academy of Orthopaedic Surgeons (AAOS), 2008
  • Recipient of Annual Research Award of American Association for Hand Surgery (AAHS) (Three awarded nationally), 2008
  • Finalist of Research Citation Award of the Society of Critical Care Medicine, 2008
  • American Heart Association (AHA) CPCC Junior Investigator travel award, 2007
  • Selected Presentation for the Press Book of The 36th Annual Meeting of the Society for Neuroscience, 2006

Grants and Contracts

NIH/NHLBI 5 RO1
X Jia (PI)
7/1/13 - 11/30/18
Brain Monitoring and Therapeutic Hypothermia after Cardiac Arrest

 

Maryland Stem Cell Research Fund (MSCRF)
X Jia (Subaward PI)
7/1/2014 – 6/30/2017
PDGF-Modified Fibrin Hydrogels for ASC-Mediated Bone Repair

 

Maryland Stem Cell Research Fund (MSCRF)
X Jia (PI)
7/01/13 - 6/30/15 NCE 6/30/16
Electrical Stimulation on Neural Crest Stem Cell Transplantation in Nerve Regeneration

 

American Heart Association
09SDG2110140
X Jia (PI)
7/1/2009-6/30/2013 NCE 6/30/2014
Quantitative Somatosensory Evoked Potential: Novel approach to Monitoring Neurologic Recovery Post Cardiac Arrest

Professional Activity

Journal Editor:

Editor-in-Chief, International Journal of Molecular Sciences (Impact Factor – 3.257, 2015),section "Translational Medicine"

Guest Editor:  International Journal of Molecular Sciences:

Special Issue: Neurological Injuries’ Monitoring, Tracking and Treatment, 2013-2016

Special Issue: Neurological Injuries’ Monitoring, Tracking and Treatment 2016, 2016-present

Special Issue: Peripheral Nerve Regeneration: From Bench to Bedside

Lead Guest Editor: BioMed Research International:

Special Issue on Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies, 2013-2014

 

Editorial Board:

Scientific Reports

International Journal of Molecular Sciences

Behavioural Neurology

Journal of Medical Engineering

ISRN Emergency Medicine

Proceedings of Neuroscience

Journal of Autoimmune Diseases and Rheumatology (JADR)

Advances in Biomedical Engineering Research (ABER)

Journal of JSM (JSciMed) Cell & Developmental Biology

Journal of JSM Regenerative Medicine

Journal of Cell Biology and Cell Metabolism (CBCM)

 

Invited Conference Abstract Grader and Reviewer

5th International Neural Regeneration Symposium (INRS2016) and the 10th Asia Pacific Symposium on Neural Regeneration (APSNR2016)

The 4-5th International Conference of Rehabilitation Medicine and Engineering, 2015

The 2015 Biomedical Engineering Society (BMES) Annual Meeting, Orthopaedic and Rehabilitation Engineering track, 2015

The 6-7th International IEEE Engineering in Medicine and Biology Society (EMBS) Conference on Neural Engineering, 2013-2015

The 38th - 45th Society of Critical Care Medicine annual Congress, 2008-2016

 

Invited Conference Moderator:

Judge, 2016 Zhu Jia-kai best case report on microsurgery, Sun Yat-sen Medicine Forum 2016, Sept 23-25, Guangzhou, China

5th International Neural Regeneration Symposium (INRS2016) and the 10th Asia Pacific Symposium on Neural Regeneration (APSNR2016)

International Committee Co-Chair, Section Chair, Moderator, The 3rd-5th International Conference of Rehabilitation Medicine and Engineering, 2014-2016

Professor Walk Round Moderator inthe 39th - 44th Society of Critical Care Medicine annual Congress, 2009-2015

Johns Hopkins University 14th Annual ACCM Research Day, 2013