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Dheeraj Gandhi, MBBS

Academic Title:

Professor

Primary Appointment:

Diagnostic Radiology and Nuclear Medicine

Secondary Appointment(s):

Neurology, Neurosurgery

Administrative Title:

Co-Director for the Center of Metabolic Imaging and Therapeutics andExecutive Committee Member for the Comprehensive Stroke Center

Additional Title:

Director, Interventional Neuroradiology; Clinical Director, Center of Metabolic Imaging and Therapeutics

Phone (Primary):

410-328-5112

Fax:

410-328-3168

Education and Training

1994   Medical School (Maulana Azad Medical College, New Delhi, India)

2000   Residency (All India Institute of Medical Sciences, New Delhi, India)

2002    Fellowship (Neuroradiology), The Ottawa Hospital, University of Ottawa, Ontario, Canada

2003    Fellowship (Neuroradiology), University of Michigan, Ann Arbor, Michigan

2004    Fellowship (Interventional Neuroradiology), University of Michigan, Ann Arbor, Michigan

Biosketch

Dr Gandhi is internationally renowned for his expertise in the treatment of intracranial and spinal vascular disorders using minimally invasive techniques.  In addition to serving as Division Chief of Interventional Neuroradiology, he is the Clinical Director of Center for Metabolic Imaging and Therapeutics (CMIT), a center of excellence for MRI Guided focused ultrasound. He directs one of the best and busiest endovascular surgical neuroradiology programs in the country, recognized for treatment of disorders such as brain aneurysms, ischemic stroke and dural arteriovenous fistulae. 

Dr Gandhi is a prolific researcher and investigator with grant funding from varied sources including NIH, Industry and Focused Ultrasound foundation. He has published over 145 manuscripts, 95 scientific abstracts and edited four books. In addition, he has contributed to several book chapters. Dr. Gandhi is a frequently invited speaker at the national and international conferences.

His work has been recognized at national and international level, resulting in numerous honors and awards. Some of his notable past achievements include Professor Shyam Sharma Medal for the best radiology resident and RSNA Research Fellow of the year award. He is a past recipient of  NERF basic science research grant, Summa Cum Laude and Magna Cum Laude awards from American Society of Neuroradiology, Bruce Line research prize, Shock Trauma Hero award and Editor's recognition award for distinction in reviewing (Radiology).

In addition to his clinical and research commitments, he has an interest in training Neuro-Interventionalists of the future. He served as fellowship director for many years and recently overseen development of an excellent Interventional Neuroradiology fellowship program at University of Maryland. This program is one of the very few in the country to receive ACGME accreditaion. Interventional Neuroradiology/Endovascular Surgical Neuroradiology program has multidisciplinary collaboration as one of its core missions to advance patient care and outcomes. 

Research/Clinical Keywords

Flow diversion for Brain aneurysms; Endosaccular (coiling) treatment of brain aneurysms; Ischemic Stroke and Mechanical Thrombectomy; Dural arteriovenous fistula; MRI guided Focused Ultrasound treatments for Essential tremors, Parkinson's disease and Neuropathic pain

Highlighted Publications

1. Le EJ, Miller T, Serulle Y, Shivashankar R, Jindal G, Gandhi D. Use of Pipeline Flex is associated with reduced fluoroscopy time, procedure time, and technical failure compared with the first-generation Pipeline embolization device. J Neurointerv Surg. 2016 Mar 9.

2. Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP Jr, Rosenblum M, Thompson RE, Awad IA; CLEAR III Investigators.. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet. 2017 Feb 11;389(10069):603-611.

3. Miller TR, Zhuo J, Jindal G, Shivashankar R, Beaty N, Gandhi D. The Efficacy of Shielding Systems for Reducing Operator Exposure during Neurointerventional Procedures: A Real-World Prospective Study. AJNR Am J Neuroradiol. 2016 Dec 22. doi: 10.3174/ajnr.A5038. [Epub ahead of print] PubMed PMID: 28007766.

4. Hanley DF, Thompson RE, Muschelli J, Rosenblum M, McBee N, Lane K, Bistran-Hall AJ, Mayo SW, Keyl P, Gandhi D, Morgan TC, Ullman N, Mould WA, Carhuapoma JR, Kase C, Ziai W, Thompson CB, Yenokyan G, Huang E, Broaddus WC, Graham RS, Aldrich EF, Dodd R, Wijman C, Caron JL, Huang J, Camarata P, Mendelow  AD, Gregson B, Janis S, Vespa P, Martin N, Awad I, Zuccarello M; MISTIE Investigators.. Safety and efficacy of minimally invasive surgery plus alteplase  in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial. Lancet Neurol. 2016 Nov;15(12):1228-1237. doi: 10.1016/S1474-4422(16)30234-4. PubMed PMID: 27751554; PubMed Central PMCID: PMC5154627.

5. Patel A, Miller TR, Shivashankar R, Jindal G, Gandhi D. Early angiographic signs of acute thrombus formation following cerebral aneurysm treatment with the  Pipeline embolization device. J Neurointerv Surg. 2016 Oct 21. pii: neurintsurg-2016-012701. doi: 10.1136/neurintsurg-2016-012701. [Epub ahead of print] PubMed PMID: 27770038.

6. Jindal G, Serulle Y, Miller T, Le E, Wozniak M, Phipps M, Iyoha M, Gupta V, Shivashankar R, Gandhi D. Stent retrieval thrombectomy in acute stoke is facilitated by the concurrent use of intracranial aspiration catheters. J Neurointerv Surg. 2016 Sep 1. pii: neurintsurg-2016-012581. doi: 10.1136/neurintsurg-2016-012581. [Epub ahead of print] PubMed PMID: 27587613.

7. Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, Schwartz M, Hynynen K, Lozano AM, Shah BB, Huss D, Dallapiazza RF, Gwinn R, Witt J, Ro S, Eisenberg HM, Fishman PS, Gandhi D, Halpern CH, Chuang R, Butts Pauly K, Tierney TS, Hayes  MT, Cosgrove GR, Yamaguchi T, Abe K, Taira T, Chang JW. A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor. N Engl J Med. 2016 Aug 25;375(8):730-9. doi: 10.1056/NEJMoa1600159. PubMed PMID: 27557301.

Awards and Affiliations

Professor Shyam Sharma Gold Medal, Best Post-Doctoral student in Radiology

Cum Laude Award, Gandhi D, Mukherji SK, Hoeffner EH, Carlos R, Case I. Initial experience with deconvolution based CT perfusion of head and neck squamous cell carcinoma. American Society of Neuroradiology. Washington, DC.

RSNA research fellow of the year, University of Michigan, Ann Arbor

Berlex /ASNR basic science research grant,    PI: Dheeraj Gandhi, Award: 50,000$ for salary support

Fellow of the Year award, Presented by the residents at the University of Michigan, Ann Arbor, in recognition of contribution to the resident teaching.

Award for outstanding service and invaluable contribution as a fellow to Neuroradiology division of University of Michigan (presented by division of Neuroradiology).

Excellence in teaching award, Presented by the residents at the University of Michigan, Ann Arbor

Excellence in teaching award, Presented by the residents at the University of Michigan, Ann Arbor

 “Magna Cum Laude Award” , Parmar H, Ibrahim, M, Gandhi, D, Mukherji S. Imaging of Perineural Spread in Head and Neck Malignancies. ASNR Annual Meeting June 2-6, 2008, New Orleans.

Best Scientific Exhibit Award: ASSR (Am Society of Spine Radiology) meeting 2010, Las Vegas

Summa Cum Laude Award: Chen J, Kathuria S, Gemmete J, Choudary N, Ansari S, Gandhi D. Endovascular Management of Symptomatic Cerebral Vasospasm with Transluminal Balloon Angioplasty. American Society of Neuroradiology Annual Meeting. Seattle, Washington. June 2011

Baltimore’s Top Doctors

Best Abstract of International Stroke Conference: 2012. Gupta R,Horev A, Wilsco D, Tayal A, Miller B, Terry J, Gandhi D, Jovin T, Hussain M, Nguyen T, Ludwig B, Cronin C, Tian M, Sheth K, Nogueira, RG. CT Perfusion Increases Time to Reperfusion and May Not Enhance Patient Selection for Endovascular Reperfusion Therapies in Acute Ischemic Stroke.

Excellence In Design award: Annual RSNA meeting 2012: Kanekar S, Parmar H, Gandhi D. Is It Recurrent, or Residual, or Radiation Necrosis or Pseudoprogression? Cellular and Molecular Imaging of Posttreatment Brain Tumor: What Physician Expects and What Radiologist Can Deliver

Bruce Line Research Prize (2014) University of Maryland School of Medicine, Department of Radiology

Shock Trauma Hero Award (2015), Shock Trauma Center, University of Maryland Baltimore

Grants and Contracts

Funding Institution:

Berlex/ASNR basic science research grant for 2003-2004.

Principal Investigator: Dheeraj Gandhi

Amount: 50,000$

"Can the choline/creatine ratio predict early treatment response of head and neck squamous cell carcinoma treated with radiation therapy in an animal model: A prospective study".

100% Effort (COMPLETED).

 

Funding institution: University of Michigan GME project

GME innovations grant 

 “Development and Assessment of a Comprehensive, Multidisciplinary, Simulator-Based Training Course in Cerebral Angiography”

Principal Investigator: Dheeraj Gandhi/Ellen Hoeffner

Amount: $ 93, 000

Effort 10% (Until Aug 2008)

 

Funding Institution: NIH/NINDS

RO1 NS38512

Familial Intracranial Aneurysm (FIA) Study

PI: Joseph Broderick

Percent Effort: 1%

Role: Institutional PI, Johns Hopkins University Hospital

 

NIH- Subcontract

ARRA/ Univ Cincinnati

Site PI

Project: Familial Intracranial Aneurysm II

Period: 09/01/10- 08/31/10

WIRB: 20041099

Direct Cost: $17,391

 

Active: Industry Sponsor – Merlin MD PTe Ltd

Project : Clinical Study of the Safety and Effectiveness of the Merlin MD Aneurysm Occlusion Device ( AOD)& Delivery System for use in the Treatment of Intracranial Aneurysm  (“study”)

Core Lab: Johns Hopkins  

PI: Dheeraj Gandhi

IRB: NA_00022333

Period: 11/01/08-10/31/10

Direct Cost: $42, 200

 

FY 11:

Continuation

ARRA/ Univ Cincinnati

Site PI

Project: Familial Intracranial Aneurysm II

Period: 09/01/10 - 08/31/11

  

FY 12:

Industry Sponsor: Arstasis

SEADONA study (Safety and Efficacy Study of Arstasis Axera Device

PI

$15,000

 

Industry Sponsor (RESEARCH AND EDUCATION GRANT):

Microvention

$40,000 (FY 2012)

 

Sponsor: MicroVention         

Start – End date: 11/2/2016 – ongoing

LVIS: Low-profile Visualized Intraluminal Support A Pivotal Study of MicroVention, Inc. Neurovascular self-expanding retrievable stent system in the treatment of wide-necked intracranial artery aneurysms

Award Amount: $34,889.00

Role: PI

Effort: 4.0%

 

Sponsor: Stryker

ULTRA: Ultra Coils from Start to Finish for the Endovascular Repair of Small Intracranial Aneurysms               

PI: Dr. Jindal  

Project costs: $ 760,000        

Start – End date: 08/01/2013 – 07/31/2016

Role: Co-PI

Effort:  2.0%

 

Sponsor: Stryker            

PI: Dr. Miller          

Start – End date: 11/25/2013 – 11/24/2017

Trevo Retriever Registry: Post Market Surveillance Study

Award Amount: $109,000

Role: Co-PI

Effort: .89%

 

Sponsor: Medtronic

Role : PI

Project Title: BARREL: Prospective, Multi-Center, Single-Arm Study of the Reverse Medical Barrel™ Vascular Reconstruction Device (VRD) for Adjunctive Treatment to Embolic Coils for Wide-Neck, Intracranial, Bifurcating/ Branching Aneurysms of Middle Cerebral and Basilar Arteries.

Effort: 1.0%

  

Insightec Tremor Study

Role: Co-PI

Effort: 2.0%

 

Project Title: Trevo Retriever Registry: Post Market Surveillance Study

Role: co-investigator

Effort: 0.89%

  

Primary recipient: Johns Hopkins University

PI: Daniel Hanley

Start – End date: 07/01/2012 – 07/30/2015

CLEAR III: Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage III study

Award Amount: $26,854.00

Effort: 2.5%

 

Primary recipient: Johns Hopkins University

PI: Daniel Hanley      

Start – End date: 09/15/2013 – 07/31/2018

MISTIE III: Minimal Invasive Surgery plus rt-PA for Intracerebral Hemorrhage Evacuation Study

Award Amount: $45, 218.01

Effort: 2.5%

 

NIH/UMCP

Start – End date: 04/01/2014 – 03/31/2016

Name of study: NICHE ROBOT in the evacuation of intracerebral hematoma in swine model

Award Amount: $144, 584.23

Role: PI

Effort: 5.0%

 

Focused Ultrasound (FUS) Foundation Grant

Start – End date: 02/17 -ongoing

Name of study:

Phase 1 Clinical Trial for MR Guided Focused Ultrasound (FUS) thalamotomy of Central lateral thalamic nucleus for the treatment of medication-refractory Neuropathic Pain.

Award Amount: $303,426 (if the two year project is realized)

Role: PI

Effort: 5.0%