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Stephen N. Davis, MBBS

Dr. Theodore E. Woodward Chair in Medicine

Academic Title:

Professor

Primary Appointment:

Medicine

Secondary Appointment(s):

Physiology

Administrative Title:

Chair, Department Of Medicine; Director, General Clinical Research Center; Director, Clinical And Translational Sciences Institute

Additional Title:

Dr. Theodore E. Woodward Chair in the Department of Medicine

Location:

UMMC N3W42

Phone (Primary):

(410) 328-2488

Education and Training

  • London University, Royal Free School of Medicine, MBBS, 1979
  • Royal College of Physicians MRCP, Internal Medicine, 1982
  • Royal College of Physicians FRCP, Internal Medicine, 2001

Biosketch

Stephen Davis, M.B.B.S., is the Theodore E. Woodward Professor of Medicine and Chairman of the Department of Medicine, Professor of Physiology and Director of the Center for Diabetes and Endocrinology at the University of Maryland School of Medicine.  Dr. Davis is Director of the General Clinical Research Center and the University of Maryland’s Clinical Translational Science Institute.  He has recently been appointed Vice President of Clinical Translational Science for the University of Maryland, Baltimore.  Dr. Davis also serves as Physician-in-Chief at the University of Maryland Medical Center. 

An internationally recognized endocrinologist and research scientist, Dr. Davis chairs the University of Maryland School of Medicine’s largest department with more than 300 full-time faculty members.  A native of the United Kingdom, he has devoted his career to treating adults with diabetes and metabolic disorders as well as studying the biological basis of certain diabetes-related complications. Dr. Davis’s major research interests include studying neural control of metabolism, exercise physiology and metabolic regulation of in-vivo vascular biology in obese, diabetic and healthy individuals.  Using state-of-the-art integrated in-vivo clinical physiologic approaches (glucose clamps, pancreatic clamps, isotopic tracer methodologies), Dr. Davis and his group have been able to identify the deficient autonomic nervous system, neuroendocrine and metabolic homeostatic mechanisms responsible for increased hypoglycemia during rest and exercise in intensively treated Type 1 and Type 2 DM individuals.  More recently, Dr. Davis’s studies have demonstrated novel treatment strategies to restore the deficient autonomic nervous system responses during hypoglycemia and exercise.  Additionally, glucose and pancreatic clamp studies have been extensively used to investigate the independent effects of insulin action and glucose on endothelial function, inflammation, and atherothrombotic balance.  Dr. Davis has substantial expertise and experience in the design, conduct, and interpretation of in-vivo human clinical physiology studies using glucose clamp and isotope dilution methodologies.   

Dr. Davis has published more than 215 original articles, reviews and textbook chapters in premier scientific journals.  For his work, Dr. Davis has been recognized with many distinguished awards throughout his career, including the Novartis Award for Diabetes Research in 2000, considered to be one of the highest honors in that field of research. Dr. Davis is listed in Who’s Who in America (2006-2014), Who’s Who in the World (2010, 2014) and Who’s Who in Healthcare (2011-2014).

Research/Clinical Keywords

Diabetes, Hypoglycemia, Exercise, Inflammation

Highlighted Publications

  • Mikeladze M, Hedrington MS, Joy N, Tate DB, Younk, LM, Davis I, Davis SN. Acute effects of oral Dehydroepiandrosterone on counterregulatory responses during repeated hypoglycemia in healthy humans. Diabetes 2016 Aug; db160406. http://dx.doi.org/10.2337/db16-0406|
  • Joy N, Perkins J, Mikeladze M, Younk L, Tate D, Davis S.  Comparative effects of acute Hypoglycemia and Hyperglycemia on Pro-Atherothrombotic biomarkers and Endothelial Function in Non-Diabetic Humans. Journal of Diabetes and its Complications. 2016, (30):1275-1281
  • Hedrington MS, Mikeladze M, Tate DB, Younk LM, Davis, IC, Davis SN. Effect of Antecedent GABA A Receptor Activation on Counterregulatory Responses to Exercise in Individuals with Type 1 Diabetes. Diabetes. 2016; Sep; 65(9): 2754-2759
  • Hedrington MS, Tate DB, Younk LM, Davis SN. Effect of antecedent GABA A receptor activation on counterregulatory responses to exercise in healthy man. Diabetes.  2015 Sep:64(9):3253-61. PMCID: PMC4542446
  • Joy NG, Tate DB, Younk LM, Davis SN. Effects of Acute and Antecedent Hypoglycemia on Endothelial Function and Markers of Atherothrombotic Balance in Healthy Man. Diabetes. 2015 64(7):2571-2580. PMCID: PMC4477350

Additional Publication Citations

  • Perkins J, Joy NG, Tate DB, Davis SN. Acute effects of hyperinsulinemia and hyperglycemia on vascular inflammatory biomarkers and endothelial function in overweight and obese humans. Am J Physiol Endocrinol Metab. 2015, 309(2):E168-76
  • Duckworth WC, Abraira C, Moritz TE, Davis SN, Emanuele N, Goldman S, Hayward R, Huang GD, Marks JB, Reaven PD, Reda DJ, Warren SR, Zieve FJ; Investigators of the VADT. The duration of diabetes affects the response to intensive glucose control in type 2 subjects: the VA Diabetes Trial. J Diabetes Complications. 2011 Nov-Dec;25(6):355-61.
  • Gogitidze Joy N, Hedrington MS, Briscoe VJ, Tate DB, Ertl AC, Davis SN. Effects of acute hypoglycemia on inflammatory and pro-atherothrombotic biomarkers in individuals with type 1 diabetes and healthy individuals. Diabetes Care. 2010 Jul;33(7):1529-35. PMCID: PMC2890354.
  • Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009 Jan 8;360(2):129-39.
  • Davis SN, Mann S, Briscoe VJ, Ertl AC, Tate DB. Effects of intensive therapy and antecedent hypoglycemia on counterregulatory responses to hypoglycemia in type 2 diabetes. Diabetes. 2009 Mar;58(3):701-9. PMCID: PMC2646069.
  • Sandoval DA, Guy DL, Richardson MA, Ertl AC, Davis SN. Acute, same-day effects of antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes mellitus. Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1331-8.
  • Sandoval DA, Ping L, Neill RA, Morrey S, Davis SN. The effects of dehydroepiandrosterone sulfate on counterregulatory responses during repeated hypoglycemia in conscious normal rats. Diabetes. 2004 Mar;53(3):679-86.  PMCID: PMC2584138
  • Galassetti P, Mann S, Tate D, Neill RA, Costa F, Wasserman DH, Davis SN. Effect of antecedent prolonged exercise on subsequent counterregulatory responses to hypoglycemia. Am J Physiol. 2001 Jun,280(6); E908-17.
  • Davis SN, Galassetti P, Wasserman DH, Tate D. Effects of antecedent hypoglycemia on subsequent counterregulatory responses to exercise. Diabetes. 2000 Jan; 49:73-81.
  • Davis SN, Mann S, Galassetti P, Neill RA, Tate D, Ertl AC, Costa F. Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans. Diabetes. 2000 Nov;49(11):1897-903.
  • Davis SN, Galassetti P, Wasserman D and Tate D.  Effects of gender on counter- regulatory responses to exercise in normal man. Journal of Clinical Endocrinology and Metabolism 2000; 85:224-230.
  • Davis SN, Shavers C, Mosqueda-Garcia R, Costa F. Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans. Diabetes. 1997 Aug;46(8):1328-35.
  • Davis SN, Shavers C, Davis B, Costa F. Prevention of an increase in plasma cortisol during hypoglycemia preserves subsequent counterregulatory responses. J Clin Invest. 1997 Jul 15;100(2):429-38. PMCID: PMC508207.
  • Davis SN, Thompson CJ, Brown MD, Peak M, Alberti KGMM.  The effect of human insulin on antibody production in non-diabetics.  Diabetes Care 1992; 15:124-126.
  • Davis SN, Monti L, Piatti P, Brown M, Hetherington C, Ashworth L, Antsiferov M, Sobey W, Hales CN, Alberti KGMM. Dose Response Characteristics of Human Proinsulin and Insulin in Non-Insulin-Dependent Diabetic Man. American Journal of Physiology 1992; 263:E28-E35.

Awards and Affiliations

  • Eli Lilly Training Fellow, 1984
  • Medical Research Council Training Fellow, 1985
  • Peel Medical Research Award, 1986
  • Mason Medical Research Foundation Award, 1987
  • Traveling Fellowship, Medical Research Council, 1988
  • Newcastle Research and Scientific Committee Research Award, 1988 
  • Southern Section AFCR Young Faculty Award, 1993
  • Novartis Award for Diabetes Research, 2000
  • Fellow, Royal College of Physicians, UK, 2001
  • Mary Jane Kugel Award, Juvenile Diabetes Research Foundation International, 2002
  • Grant W. Liddle Award for Clinical Research, 2005
  • Chair, Hypoglycemia and Clinical Complications, American Diabetes Association meeting, 2005
  • Fellow, American College of Endocrinologists, 2008
  • Fellow, American College of Physicians, 2009
  • Master, American College of Physicians, 2016

Video: Dr. Stephen Davis & Diabetes Research at the University of Maryland School of Medicine