Skip to main content

Joana Carneiro da Silva, PhD

Academic Title:

Associate Professor

Primary Appointment:

Microbiology and Immunology

Additional Title:

Associate Professor, Institute for Genome Sciences; Associate Member, Institute for Global Health, Division of Malaria Research, University of Maryland School of Medicine; Affiliate Faculty, School of Systems Biology, George Mason University

Location:

BioPark II, 645

Phone (Primary):

(410) 706-0817

Phone (Secondary):

(410) 706-6755

Fax:

(410) 706-6756

Education and Training

1992                B.Sc., Biology, Universidade Clássica de Lisboa, Faculty of Sciences, Lisbon, Portugal

2000                Ph.D., Genetics, The University of Arizona, Tucson, AZ, USA (Advisor: Margaret G Kidwell)

2000-2002       Fogarty Postdoctoral Fellow, National Center for Biotechnology Information (NCBI), National Institutes of Health, Bethesda, MD, USA (Advisor: Alexey A Kondrashov)

2002-2005       Staff Scientist, The Institute for Genomic Research (TIGR), Rockville, MD, USA (Advisor: Jane M Carlton)

Biosketch

My group applies evolutionary genetics and genomic sciences to both basic research on species evolution and translational research of infectious diseases. I have been studying infectious disease genomics for close to 15 years. At The Institute for Genomic Research (TIGR) I was part of the team that launched the field of parasite genomics, with work on several Plasmodium and trypanosomatid species, Theileria parva and Trichomonas vaginalis. At the Institute for Genome Sciences, University of Maryland School of Medicine, we have ongoing projects on a variety of parasites in the phylum Apicomplexa. These include the causative agents of malaria in humans (genus  Plasmodium), tropical theileriosis and East Coast fever in cattle (genus Theileria), human babesiosis (genus  Babesia), and human cryptosporidiosis (genus  Cryptosporidium).

Ongoing projects include the (i) the study of species biology and the nature of host-parasite interactions, based on the generation and analyses of new reference genomes and (ii) studies of speciation, drug resistance, vaccine efficacy and vaccine design, informed by population genomics data. Our research is funded by NSF, NIH, USDA and the Bill and Melinda Gates Foundation.

 

Research/Clinical Keywords

Parasites: Plasmodium, Cryptosporidium, Babesia, Theileria; Genomics, Transcriptomics; Reverse vaccinology; Vaccine design, Vaccine efficacy

Highlighted Publications

Epstein JE, Paolino KM, Richie TL, Sedegah M, Singer A, Ruben AJ, Chakravarty  S, Stafford A, Ruck RC, Eappen AG, Li T, Billingsley PF, Manoj A, Silva JC, Moser K, Nielsen R, Tosh D, Cicatelli S, Ganeshan H, Case J, Padilla D, Davidson S, Garver L, Saverino E, Murshedkar T, Gunasekera A, Twomey PS, Reyes S, Moon JE, James ER, Kc N, Li M, Abot E, Belmonte A, Hauns K, Belmonte M, Huang J, Vasquez C, Remich S, Carrington M, Abebe Y, Tillman A, Hickey B, Regules J, Villasante E, Sim BK, Hoffman SL. Protection against Plasmodium falciparum malaria by PfSPZ Vaccine. JCI Insight. 2017 Jan 12;2(1):e89154. PubMed PMID: 28097230.

Silva JC, E Cornillot, C McCracken, S Usmani-Brown, A Dwivedi, OO Ifeonu, J Crabtree, HT Gotia, AZ Virji, C Reynes, J Colinge, V Kumar, L Lawres, JE Pazzi, JV Pablo, C Hung, J Brancato, P Kumari, J Orvis, K Tretina, MC Chibucos, S Ott, L Sadzewicz, N Sengamalay, AC Shetty, Q Su, L Tallon, CM Fraser, R Frutos, DM Molina, P Krause, CB Mamoun. Genome-wide diversity and gene expression profiling of Babesia microtiisolates identify polymorphic genes that mediate host-pathogen interactions. Sci Rep. 2016 Oct 18;6:35284. PMID: 27752055.

Ifeonu OO, R Simon, SM Tennant, AS Sheoran, JC Kissinger, G Widmer, MM Levine, S Tzipori, JC SilvaCryptosporidium hominis Gene Catalog: A Resource for Selecting Novel Vaccine Candidates Using Reverse Vaccinology. Database (Oxford). 2016 Oct 19;2016. pii: baw137. PubMed PMID: 28095366.

    Silva JC, Egan A, Arze C, Spouge JL, Harris DG. A new method for estimating species age supports the coexistence of malaria parasites and their mammalian hosts. Mol Biol Evol. 2015 May;32(5):1354-64. PMID: 25589738.

    Norling M, Bishop RP, Pelle R, Qi W, Henson S, Drábek EF, Tretina K, Odongo D, Mwaura S, Njoroge T, Bongcam-Rudloff E, Daubenberger CA, Silva JC. The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence. BMC Genomics. 2015 Sep 24;16(1):729. PMID: 26403690. 

    Google Scholar profile

    Additional Publication Citations

    Apicomplexan Parasites

        Epstein JE, Paolino KM, Richie TL, Sedegah M, Singer A, Ruben AJ, Chakravarty  S, Stafford A, Ruck RC, Eappen AG, Li T, Billingsley PF, Manoj A, Silva JC, Moser K, Nielsen R, Tosh D, Cicatelli S, Ganeshan H, Case J, Padilla D, Davidson S, Garver L, Saverino E, Murshedkar T, Gunasekera A, Twomey PS, Reyes S, Moon JE, James ER, Kc N, Li M, Abot E, Belmonte A, Hauns K, Belmonte M, Huang J, Vasquez C, Remich S, Carrington M, Abebe Y, Tillman A, Hickey B, Regules J, Villasante E, Sim BK, Hoffman SL. Protection against Plasmodium falciparum malaria by PfSPZ Vaccine. JCI Insight. 2017 Jan 12;2(1):e89154. PubMed PMID: 28097230.

        Silva JCE Cornillot, C McCracken, S Usmani-Brown, A Dwivedi, OO Ifeonu, J Crabtree, HT Gotia, AZ Virji, C Reynes, J Colinge, V Kumar, L Lawres, JE Pazzi, JV Pablo, C Hung, J Brancato, P Kumari, J Orvis, K Tretina, MC Chibucos, S Ott, L Sadzewicz, N Sengamalay, AC Shetty, Q Su, L Tallon, CM Fraser, R Frutos, DM Molina, P Krause, CB Mamoun. Genome-wide diversity and gene expression profiling of Babesia microtiisolates identify polymorphic genes that mediate host-pathogen interactions. Sci Rep. 2016 Oct 18;6:35284. PMID: 27752055.

        Ifeonu OO, R Simon, SM Tennant, AS Sheoran, JC Kissinger, G Widmer, MM Levine, S Tzipori, JC SilvaCryptosporidium hominis Gene Catalog: A Resource for Selecting Novel Vaccine Candidates Using Reverse Vaccinology. Database (Oxford). 2016 Oct 19;2016. pii: baw137. PubMed PMID: 28095366.

          Ifeonu OO, M Chibucos, J Orvis, Q Su, K Elwin, F Guo, H Zhang, L Xiao, M Sun, RM Chalmers, CM Fraser, G Zhu, JC Kissinger, G Widmer, JC Silva. Annotated Draft Genome Sequences of Cryptosporidium meleagridis isolate UKMEL1, Cryptosporidium baileyi isolate TAMU-09Q1, and Cryptosporidium hominis isolates TU502_2012 and UKH1. Pathog Dis. 2016 Oct;74(7). pii: ftw080. PMID: 27519257.

          Gotia HT, JB Munro, DP Knowles, CA Daubenberger, RP Bishop, JC Silva. Quantification of the ratio of host-to-parasite DNA in samples from Theileria parva-infected host lymphocyte cell lines. PLoS One. 2016 11(3):e0150401. PMID: 26930209. 

          Tretina K, R Pelle and JC Silva. Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva. BMC Genomics. 2016 17(1):128. PMID: 26896950. 

          Norling M, Bishop RP, Pelle R, Qi W, Henson S, Drábek EF, Tretina K, Odongo D, Mwaura S, Njoroge T, Bongcam-Rudloff E, Daubenberger CA, Silva JC. The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence. BMC Genomics. 2015 Sep 24;16(1):729. doi: 10.1186/s12864-015-1910-9. PMID: 26403690.

          Tretina, K., Gotia HT, Mann D, Silva JC. Theileria-transformed bovine leukocytes have cancer hallmarks. Trends Parasitol. 2015 Jul;31(7):306-14. doi: 10.1016/j.pt.2015.04.001. Review. PMID: 25951781.

          Obara I, Ulrike S, Musoke T, Spooner PR, Jabbar A, Odongo D, Kemp S, Silva JC, Bishop RP. Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva. Parasitol Res. 2015 May; 114(5):1729-37. doi: 10.1007/s00436-015-4358-6. PMID: 25673078.

          Silva JC, Egan A, Arze C, Spouge JL, Harris DG. A new method for estimating species age supports the coexistence of malaria parasites and their Mammalian hosts. Mol Biol Evol. 2015 May;32(5):1354-64. doi: 10.1093/molbev/msv005. PMID: 25589738

          Brown TS, Jacob CG, Silva JC, Takala-Harrison S, Djimdé A, Dondorp AM, Fukuda  M, Noedl H, Nyunt MM, Kyaw MP, Mayxay M, Hien TT, Plowe CV, Cummings MP. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype. Infect Genet Evol. 2015 Mar;30:318-22. doi: 10.1016/j.meegid.2014.12.010. PMID: 25514047.

          Takala-HarrisonS, JacobCG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NTT, Imwong M, Bethell D, Y S, Lon C, Stuart D. Tyne SD, Saunders DL, Socheat D, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer H-P, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, and Plowe CV. Independent emergence of Plasmodium falciparum artemisinin resistance mutations in Southeast Asia. Journal Infectious Diseases. 2015 Mar 1;211(5):670-9. doi: 10.1093/infdis/jiu491. Epub 2014 Sep 1. PubMed PMID: 25180241.

          Cornillot E, Dassouli A, Garg A, Pachikara N, Randazzo S, Depoix D, Carcy B, Delbecq S, Frutos R, Silva JC, Sutton R, Krause PJ, Mamoun CB. Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates. PLoS One. 2013 Sep 4;8(9):e72657. PMID: 24023759.

          Takala-Harrison S., T.G. Clark, C.G. Jacob, M.P. Cummings, O. Miotto, A.M. Dondorp, M.M Fukuda, F. Nosten, H. Noedl, M. Imwong, D. Bethell, Y. Se, C. Lon, S. .D Tyner, D. Saunders, D. Socheat, F. Ariey, A. Pyae Phyo, P. Starzengruber, H-P Fuehrer, P. Swoboda, K. Stepniewska, J. Flegg, C. Arze, G.C. Cerqueira, J.C. Silva, S.M. Ricklefs, S.F. Porcella, R.M. Stephens, M. Adams, L.J Kenefic, S. Campino, S. Auburn, B. MacInnis, D.P. Kwiatkowski, X-Z Su, N.J. White, P. Ringwald, C.V. Plowe. 2013. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. PNAS 110: 240-5. PMID: 23248304.

          Kappmeyer L.S., M. Thiagarajan, D.R. Herndon, J.D. Ramsay, E. Caler, A. Djikeng, J.J. Gillespie, A.O.T. Lau, E.H. Roalson, J.C. Silva, M.G. Silva, C.E. Suarez, M.W. Ueti, V.M. Nene, R.H. Mealey, D.P. Knowles and K.A. Brayton. 2012. Comparative genomic analysis and phylogenetic position of Theileria equi. BMC Genomics 13(1):603. PMID: 23137308.

          Munro JB and JC Silva. 2011. Ribonucleotide reductase as a drug target for apicomplexan parasites. Curr Issues Mol Biol. 14(1):9-26. PMID: 21791713.

          Pelle, R., S.P. Graham, M. Njahira, J. Osaso, R.M. Saya, D.O. Odongo, P.G. Toye, P.R. Spooner, A.J. Musoke, D.M. Mwangi, E.L. Taracha, I.W. Morrison, W.Weir, J.C. Silva, and R.P. Bishop. 2011. Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity. PLoS One 6(4): e19015. PMID:21559495.

          Silva, J.C., A. Egan, R. Friedman, J.B. Munro, J.M. Carlton, A.L. Hughes. 2011. Genome sequences reveal divergence times of malaria parasite lineages. Parasitology 138:1737-49. PMID: 21118608.

          Guo X and JC Silva. 2008. Properties of non-coding DNA and identification of putativecis-regulatory regions in Theileria parva. BMC Genomics 9:582. PMID:19055776.

          Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P, Cheng Q, Coulson RM, Crabb BS, Del Portillo HA, Essien K, Feldblyum TV, Fernandez-Becerra C, Gilson PR, Gueye AH, Guo X, Kang'a S, Kooij TW, Korsinczky M, Meyer EV, Nene V, Paulsen I, White O, Ralph SA, Ren Q, Sargeant TJ, Salzberg SL, Stoeckert CJ, Sullivan SA, Yamamoto MM, Hoffman SL, Wortman JR, Gardner MJ, Galinski MR, Barnwell JW, Fraser-Liggett CM. Comparative genomics of the neglected human malaria parasite Plasmodium vivaxNature. 2008 Oct 9;455(7214):757-63. doi: 10.1038/nature07327. PMID: 18843361.

          Carlton, J.M., J.C. Silva, and N. Hall. 2005. The genome of model malaria parasites, and comparative genomics. Curr. Issues Mol. Biol. 7: 23-37.

          Gardner MJ, Bishop R, Shah T, de Villiers EP, Carlton JM, Hall N, Ren Q, Paulsen IT, Pain A, Berriman M, Wilson RJ, Sato S, Ralph SA, Mann DJ, Xiong Z, Shallom SJ, Weidman J, Jiang L, Lynn J, Weaver B, Shoaibi A, Domingo AR, Wasawo D, Crabtree J, Wortman JR, Haas B, Angiuoli SV, Creasy TH, Lu C, Suh B, Silva JC, Utterback TR, Feldblyum TV, Pertea M, Allen J, Nierman WC, Taracha EL, Salzberg SL, White OR, Fitzhugh HA, Morzaria S, Venter JC, Fraser CM, Nene V. Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. Science. 2005 Jul 1;309(5731):134-7. PMID: 15994558.

          Carlton JM, Angiuoli SV, Suh BB, Kooij TW, Pertea M, Silva JC, Ermolaeva MD, Allen JE, Selengut JD, Koo HL, Peterson JD, Pop M, Kosack DS, Shumway MF, Bidwell SL, Shallom SJ, van Aken SE, Riedmuller SB, Feldblyum TV, Cho JK, Quackenbush J, Sedegah M, Shoaibi A, Cummings LM, Florens L, Yates JR, Raine JD, Sinden RE, Harris MA, Cunningham DA, Preiser PR, Bergman LW, Vaidya AB, van Lin LH, Janse CJ, Waters AP, Smith HO, White OR, Salzberg SL, Venter JC, Fraser CM, Hoffman SL, Gardner MJ, Carucci DJ. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature. 2002 Oct 3;419(6906):512-9. PMID: 12368865.

           

          Non-Apicomplexan Parasites and Other Organism

          Dugan VG, Emrich SJ, Giraldo-Calderón GI, Harb OS, Newman RM, Pickett BE, Schriml LM, Stockwell TB, Stoeckert CJ Jr, Sullivan DE, Singh I, Ward DV, Yao A, Zheng J, Barrett T, Birren B, Brinkac L, Bruno VM, Caler E, Chapman S, Collins FH, Cuomo CA, Di Francesco V, Durkin S, Eppinger M, Feldgarden M, Fraser C, Fricke WF, Giovanni M, Henn MR, Hine E, Hotopp JD, Karsch-Mizrachi I, Kissinger JC, Lee EM, Mathur P, Mongodin EF, Murphy CI, Myers G, Neafsey DE, Nelson KE, Nierman WC, Puzak J, Rasko D, Roos DS, Sadzewicz L, Silva JC, Sobral B, Squires RB, Stevens RL, Tallon L, Tettelin H, Wentworth D, White O, Will R, Wortman J, Zhang Y, Scheuermann RH. Standardized Metadata for Human Pathogen/Vector Genomic Sequences. PLoS One. 2014. 9(6):e99979. PMID: 24936976.

          Fedorova, N.D., N. Khaldi, V.S. Joardar, R. Maiti, P. Amedeo, M.J. Anderson, J. Crabtree, J.C. Silva, J.H. Badger, A. Albarraq, S. Angiuoli, H. Bussey, P. Bowyer, P.J. Cotty, P.S. Dyer, A. Egan, K. Galens, C.M. Fraser-Liggett, B.J. Haas, J.M. Inman, R. Kent, S. Lemieux, Malavazi, J. Orvis, T. Roemer, C.M. Ronning, J.P. Sundaram, G. Sutton, G. Turner, J.C. Venter, O.R. White, B.R. Whitty, P. Youngman, K.H. Wolfe, G.H. Goldman, J.R. Wortman,   B. Jiang, D.W. Denning, W.C. Nierman. 2008. Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLoS Genetics 4:e1000046. PMID:18404212.

          Carlton, J.M., R.P. Hirt, J.C. Silva, A.L. Delcher, M. Schatz, Q. Zhao, J.R. Wortman, S.L. Bidwell, U.C.M. Alsmark, S. Besteiro, T. Sicheritz-Ponten, C.J. Noel, J.B. Dacks, P.G. Foster, C. Simillion, Y. Van de Peer, D. Miranda-Saavedra, G.J. Barton, G.D. Westrop, S. Müller, D. Dessi, P.L. Fiori, Q. Ren, I. Paulsen, H. Zhang, F.D. Bastida-Corcuera, A. Simoes-Barbosa, M.T. Brown, R.D. Hayes, M. Mukherjee, C.Y. Okumura, R. Schneider, A.J. Smith, S. Vanacova, M. Villalvazo, B.J. Haas, M. Pertea, T. Feldblyum, T.R. Utterback, C.-L. Shu, K. Osoegawa, P.J. de Jong, I. Hrdy, L. Horvathova, Z. Zubacova, P. Dolezal, S.-B. Malik, J.M. Logsdon, Jr., K. Henze, A. Gupta, C.C. Wang, R.L. Dunne, J.A. Upcroft, P. Upcroft, O. White, S.L. Salzberg, P. Tang, C.-H. Chiu, Y.-S. Lee, T.M. Embley, G.H. Coombs, J.C. Mottram, J. Tachezy, C.M. Fraser-Liggett and P.J. Johnson. 2007. Draft Genome Sequence of the Sexually-Transmitted Pathogen Trichomonas vaginalis. Science 315: 207-212. PMID:17218520.

          Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK Jr, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA, Krieger CJ, del Toro C, Ryder HF, Williamson SC, Barbeau RA, Hamilton EP, Orias E. Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol. 2006 Sep;4(9):e286. PMID: 16933976

          El-Sayed N.M., P.J. Myler, G. Blandin, M. Berriman, J. Crabtree, G, Aggarwal, E. Caler, H. Renauld, E.A. Worthey C. Hertz-Fowler, E. Ghedin, C. Peacock, D.C. Bartholomeu, B. J. Haas, A.N. Tran, J.R. Wortman, U.C. Alsmark, S. Angiuoli, A. Anupama, J. Badger, F.  Bringaud, E. Cadag, J.M. Carlton, G.C. Cerqueira, T. Creasy, A.L. Delcher, A. Djikeng, T.M. Embley, C. Hauser, A.C. Ivens, S.K. Kummerfeld, J.B. Pereira-Leal, D. Nilsson, J. Peterson, S.L. Salzberg, J. Shallom, J.C. Silva, J. Sundaram, S. Westenberger, O. White, S.E. Meilville, J.E. Donelson, B. Andersson, K.D. Stuart, N. Hall. 2005. Comparative genomics of the trypanosomatid parasitic protozoa. Science 309: 404-409.

           

          Genome Evolution

          Egan A, A Mahurkar, J Crabtree, JH Badger, JM Carlton, JC Silva. 2008. IDEA: Interactive Display for Evolutionary Analyses. BMC Bioinformatics 9:524. PMID: 19061522.

          Lin, H., S. Ouyang, A. Egan, K. Nobuta, B.J. Haas, W. Zhu, X. Gu, J.C. Silva, B.C. Meyers, and C.R. Buell. 2008. Characterization of paralogous protein families in rice. BMC Plant Biology 8: 18. PMID:18284697.

          Lin, H., W. Zhu, J.C. Silva, X. Gu and R. Buell. 2006. Intron turnover of segmentally duplicated genes in rice. Genome Biology: 7: R4.

          Silva, J.C., S.A. Shabalina, D.G. Harris, J. Spouge and A.S. Kondrashov. 2003. Conserved transposable elements in intergenic regions: recruitment of MIR- and L2-derived sequences in the mouse and human genomes. Genet. Res. 82:1-18.

          Silva JC and AS Kondrashov. 2002.Patterns in spontaneous mutation revealed by human-baboon sequence comparison. Trends Genetics 18:544-547. 

          Yang H.-P., A.Y. Tanikawa, W.A. Van Voorhies, J.C. Silva, A.S.Kondrashov. 2001. Whole-genome effects of ethyl methanesulfonate-induced mutation on nine quantitative traits in   outbred Drosophila melanogaster. Genetics 157:1257-65.

           

          Transposable Elements

          Lopes F.R., J.C. Silva, M. Benchimol, G.G.L. Costa, G.A.G. Pereira and C.M.A. Carareto. 2009. The protist Trichomonas vaginalis harbors multiple lineages of transcriptionally active Mutator-like elements. BMC Genomics 10:330. PMID: 19622157.

          Silva, J.C., F. Bastida, S.L. Bidwell, P.J. Johnson and J.M. Carlton. 2005. A potentially functional mariner transposable element in the protist Trichomonas vaginals. Mol. Biol. Evol. 22: 126-134. PMID:15371525.

          Carvalho, M.O., J.C. Silva,and ELS Loreto. 2004. Analyses of P-like transposable element sequences from the genome of Anopheles gambiae. Insect Mol. Biol. 13:55-63. 

          Silva, J.C., E.L. Loreto and J.B. Clark. 2004. Factors that affect horizontal transfer of transposable elements. Curr. Issues Mol. Biol. 6:57-72. PMID:14632259.

          Silva, J.C. and M.G. Kidwell. 2004. Evolution of P elements in natural populations of Drosophila willistoni and D. sturtevanti. Genetics 168: 1323-1335.

          Silva, J.C., S.A. Shabalina, D.G. Harris, J. Spouge and A.S. Kondrashov. 2003. Conserved transposable elements in intergenic regions: recruitment of MIR- and L2-derived sequences in the mouse and human genomes. Genet. Res. 82:1-18.Loreto, E.L.S., L.B. da Silva, A. Zaha, J.C. Silva, V.L.S. Valente and M.G. Kidwell. 2001. Drosophila mediopunctata P elements: a new example of horizontal transfer. Journal of Heredity 92: 3381. PMID:11773243.

          Silva, J.C., and M.G. Kidwell. 2000. Horizontal transfer and selection in P transposable elements. Mol. Biol. Evol. 17: 1542-1557.

          Carareto, C.M.A., W. Kim, M.F. Wojciechowski, P.M. O'Grady, A.V. Prokchorova, J.C. Silva and M.G. Kidwell. 1997.  Testing transposable elements as genetic drive mechanisms using   Drosophila P element constructs as a model system. Genetica 101:13-33.

          Awards and Affiliations

          1992-1996       Doctoral Research Fellowship, Junta Nacional de Investigação Científica e Tecnológica (JNICT), Portugal

          1997-1999       Doctoral Dissertation Improvement Award, National Science Foundation

          1997-1998       NSF Research Training Group in the Analysis of Biological Diversification Research Fellowship, The University of Arizona

          1998-1999       Robert S. Flinn Foundation Research Fellowship, The University of Arizona

          2000-2002       Fogarty International Post-doctoral Fellowship, National Institutes of Health

          2011-present    Affiliate Member, Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine

          2013                2013 Maryland’s Top 100 Women Award, The Daily Record. Maryland’s Top 100 Women recognizes high-achieving Maryland women who are making an impact through their leadership, community service and mentoring.

          2014-present    Affiliate Faculty, School of Systems Biology, George Mason University

          2016                Baltimore City Community College (BCCC), Partnership Award. This award is granted to BCCC community partners who contribute to the success of BCCC programs and the academic development of its students.

          2016                Dr. Patricia Sokolove Outstanding Mentor Award. The award was established by the UMB Graduate Student Association (GSA) to honor those who put forth great effort in aiding and mentoring graduate students. 

          Links of Interest

          Institute for Genome Sciences (IGS) - International Livestock Research Institute (ILRI) Partnership: IGS-ILRI Pathogen Genomics

          Cryptosporidium hominis Gene Catalog

          Joana Carneiro da Silva, PhD

          Academic Title:

          Associate Professor

          Primary Appointment:

          Microbiology and Immunology