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Aditi Banerjee, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Pediatrics

Location:

Bressler Research Building, 13-026

Phone (Primary):

410-706-8778

Education and Training

  • University of Calcutta, India, B.Sc, Zoology, 1987
  • Jadavpur University, India, Diploma in Pathology. 1998
  • University of Kalyani, M.Sc, Zoology, 1990
  • University of Kalyani, Ph.D., Zoology, 1996

Biosketch

Dr. Banerjee is a cell biologist with multiple interests including the molecular mechanisms of wound healing, gastric inflammation, gastric ulcer healing, and cancer. She has studied the effect of free and encapsulated  bioactive molecules including curcumin, melatonin and antioxidants on cancer models with respect to angiogenesis and the regulation of matrix metalloproteinases (MMPs). She has also studied the role of galectin in innate immunity to viral and bacterial infections of the lung and the role of galectin 3 in cancer metastasis.

More recently, she has focused on the plant metabolite andrographolide (AGP) which is widely recognized for its anti-inflammatory and anti-cancer activity. She has utilized an in vitro colon cancer cell model to demonstrate that AGP induced apoptosis of cancer cells is the result of AGP-induced endoplasmic reticulum (ER) stress through the unfolded protein response (UPR). Moreover, her recent work demonstrates that AGP induces ER stress through the induction of ROS. Elevated ROS levels play an important role in down-regulating cell cycle progression and cell survival pathways. In addition, she has shown that AGP induces the expression of the RASSF1A and PTEN tumor suppressor genes which are typically suppressed in colon cancer. These findings illustrate some of the molecular pathways by which AGP kills cancer cells. Her ongoing work includes continuing to define AGP induced anti-cancer pathways and the development of AGP as a potential chemotherapeutic agent for colon cancer treatment.

Research/Clinical Keywords

Unfolded protein response, Endoplasmic Reticulum Stress, Antioxidant, Reactive Oxygen species, Tumor Suppressor Gene, Signal Transduction, Apoptosis, Gene knockout, chemotherapy

Highlighted Publications

Banerjee A, Banerjee V, Czinn SJ, Blanchard TG. (2017) Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells. Oncotarget. DOI: 10.18632/onco.

Banerjee A, Ahmed H, Yang P, Czinn SJ, Blanchard TG. (2016) Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment. Oncotarget. 7(27):41432-41444.

Banerjee A, Basu M, Blanchard TG, Chintalacharuvu SR, Guang W, Lillehoj EP, Czinn SJ. (2016) Early Molecular Events in Murine Gastric Epithelial Cells Mediated by Helicobacter pylori CagA. Helicobacter. 21(5):395-404.

Lazar MN*, Banerjee A *, Feng C, Amin MN, Frieman MB, Chen WH, Cross AS, Wang LX, Vasta GR (*equal contribution) (2015).  Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding. Molecular Immunology,65: 1-16. 

Banerjee A, Lang JU, Hung MC, Sengupta K, Banerjee SK, BaksiK, Banerjee DK (2011). Unfolded Protein Response is Required In Nu/Nu Mice Microvasculature for Treating Breast Tumor with Tunicamycin.The Journal of Biological Chemistry, 286(33), 29127-29138.

Awards and Affiliations

  • Member, American Society for Biochemistry & Molecular Biology, 2013- present
  • Travel Award, American Society for Biochemistry and Molecular Biology annual meeting. 2008
  • Cover page, Arthritis Rheumatism Journal, 2008
  • Travel Award, American Society for Biochemistry and Molecular Biology annual meeting, 2010

Previous Positions

  • Research Associate, University of Maryland School of Medicine, 2014-2016
  • Post Doctoral Associate, University of Maryland School of Medicine, 2011-2014
  • Post Doctoral Associate, University of Puerto Rico School of Medicine, 2006-2011
  • Research Associate, Indian Institute of Chemical Biology, India, 2001-2006
  • Senior Research Fellow. Indian Research Institute for Integrated Medicine, India, 1999