William  F Regine
View Curriculum Vitae 

William F Regine M.D.

Academic Title: Professor
Primary Appointment: Radiation Oncology
Administrative Title: Chair
wregine@umm.edu
Location: UMMC/Gudelsky, GGK-0101
Phone: (410) 328-2326
Fax: (410) 328-6911

Personal History

Dr. Regine received his medical degree from the State University of New York Health Science Center at Syracuse and served his residency at Thomas Jefferson University Hospital in Philadelphia. He was also a fellow in the Department of Radiation Oncology at Thomas Jefferson and at the University of Florida. From 1992 to 1994, Dr. Regine was assistant professor of radiation oncology at the University of Tennessee and served as the acting clinical chief of radiation oncology. Dr. Regine came to the University of Maryland from the University of Kentucky, where he was professor of radiation medicine and neurosurgery and vice chairman of the Department of Radiation Medicine. He was co-director of the gamma knife radiosurgery program and the former associate director for clinical research at the Markey Cancer Center at the University of Kentucky.

Research Interests

Dr. Regine's research interests include the study and treatment of pancreas/gastrointestinal cancers, brain tumors and head and neck cancers. He is alwo working on an innovative drug delivery device for the treatment of brain tumors. 

Clinical Speciality

Gastrointestinal Malignancies,  Pancreatic cancer, Central Nervous System malignancies, Stereotactic Body Radiation Therapy (SBRT) and gamma knife radiosurgery.

Current Investigational Studies:

A feasibility study of neurocognitive evaluation in patients treated for brain metastases. RTOG Protocol #BR-0018 [ Principal Investigator/Study Chairman ] – Activated

A Phase II trial of conventional radiation therapy followed by intratumoral bleomycin delivered using a refillable, sustained release device (IND# 46,592) for the treatment of supratentorial glioblastoma.  RTOG Protocol #BR-0013 [ Study Co-Chairman ] - Activated

A Phase I/II Postoperative Adjuvant Therapy with Gemcitabine and Gemcitabine and Irradiation Following Pancreaticoduodenectomy for Pancreatic Adenocarcinoma Resected with Curative Intent.  RTOG Protocol #0414 [Study Co-Chairman]


Publications

Books and Chapters

Regine WF. Postoperative Adjuvant Therapy for Pancreatic Cancer: Past, Present, and Future Trial Development. In: MD Anderson Solid Tumor Oncology Series: Pancreatic Cancer. Evans DB, Pisters PWT, Abbruzzese JL, eds. Spinger-Verlag, 2001;235-242.

Regine WF, Hanna N, DeSimone P, Cohen A. Rectal Cancer. In: Clinical Oncology, 3rd Edition Abeloff M, ed. Churchill Livingston, 2003; 1943-1966.

Kwok Y, Garofalo MC, Regine WF. Postoperative Adjuvant Therapy and the Rationale for the US Intergroup Trial. In: Van Hoff D, Evans D, Hruban, RH, eds. Jones and Bartlett, 2005;395-404.

Garofalo MC, Flannery T, Regine WF. The Case for Adjuvant Chemoradiation for Pancreatic Cancer. In: Best Practice & Research Clinical Gastroenterology, eds. Elsevier, Vol 20, No 2, pp. 403-416, 2006.

Patel S, Garofalo MC, Regine WF. Role of Radiotherapy in Treatment of Pancreatic Cancer. (Chapter 81) In: Beger H, Bulcher M, Kozarek R, eds. The Pancreas, 2nd Edition Blackwell Publishing, Ltd, 2006 (In press).

Kwok Y, Patchell RA, Regine WF. Palliation of Brain and Spinal Cord Metastases. In: Principles & Practice of Radiation Oncology, 5th Edition, Lippincott Publishing (In Press).

Suh JH, Barnett GH, Regine WF. Stereotactic Radiosurgery for Brain Metastases. In: Chin LC, Regine WF eds. Principles & Practice of Stereotactic Radiosurgery. Springer-Verlag Publishing. (In Press)

Patchell RA, Regine WF. Whole Brain Radiation Therapy for Brain Metastases. In: Chin LC, Regine WF, eds. Principles & Practice of Stereotactic Radiosurgery. Springer-Verlag Publishing (In Press).

Chin LC, Regine WF., eds. Principles & Practice of Stereotactic Radiosurgery. Springer-Verlag Publishing (In Press).


Selected Recent Journal Articles

Sathishkumar S, Dey S, Meigooni AS, Regine WF, Kudrimoti M, Ahmed MM, Mohiuddin M. The Impact of TNF-a Induction on Therapeutic Efficacy Following High Dose Spatially Fractionated (GRID) Radiation. Technology in Cancer Research and Treatment 1: 141-147, 2002.

Mohiuddin M, Chendil D, Dey S, Alcock RA, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 Status on Radiation and 5-Flourouracil Synergy in Pancreatic Cancer Cells. Anticancer Research 22: 825-830, 2002.

Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, Regine WF, Weltman E, King VJ, Breneman JC, Sperduto PW, Mehta MP. A Multi-Institutional Review of Radiosurgery Alone vs. Radiosurgery with Whole Brain Raditherapy as the Initial Management of Brain Metastases. Int J Radiat Oncol Biol Phys 53(3): 519-526, 2002.

Valentino J, Spring PM, Shane M, Arnold SM, Regine WF. Interval Pathologic Assessments In Patients Treated with Concurrent Hyperfractionated Radiation and Intraarterial Cisplatin (Hyperradplat). Head and Neck 24: 539-544, 2002.

Hahn SM, Bernard EJ, Regine WF, Mohiuddin M, Haller DG, Stevenson JP, Smith D, Pramanik, B, Tepper J, Delaney TF, Kiel KD, Morrison B, Deutsch P, Muschel RJ, McKenna WG. A Phase I Trial of the Farnesyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Lung and Head and Neck Cancer. Clinical Cancer Research 8: 1065-1072, 2002.

Mohiuddin M, Kudrimoti M, Regine WF, McGrath P, Hanna N, Meeker T, John W. Concurrent Infusional Gemcitabine and Radiation in the Treament of Advanced Unresectable GI Malignancy: A Phase I Study. Cancer Journal 8: 255-262, 2002.

Mohiuddin M, Damodaran C, Swatee D, Alcock R, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 Status on Radiation and 5 - Flourouracil Synergy in Pancreatic Cancer Cells. Anticancer Research 22: 825-830, 2002.

Patchell RA, Regine WF, Ashton P, Tibbs PA, Wilson D, Shappley D, Young BY. A phase I Trial of Continuously Infused Intratumoral Bleomycin for the Treatment of Recurrent Glioblastoma Multiforme. J Neuro-Onc 60: 37-42, 2002.

Dey S, Spring PM, Arnold S, Valentino J, Chendil D, Regine WF, Mohiuddin M, Ahmed MM. Low-Dose Fractionated Radiation Potentiates the Effects of Paclitaxel in Wild-type and Mutant p53 Head and Neck Tumor Cell Lines. Clin Ca Res 9: 1557-1565, April 2003.

Anderson T, Regine WF, Kryscio R, Patchell RA. Neurologic complications of bladder cancer. A review of 359 cases. Cancer 97: 2267-72, 2003.

Patchell RA, Regine WF. The Rational for Adjuvant Whole Brain Radiation Therapy with Radiosurgery in the Treatment of Single Brain Metastases. Tech Ca Res Treat 2(2): 111-115, 2003.

Chin LS, Szerlip NJ, Regine WF. Stereotactic Radiosurgery for meningiomas. Neurosurg Focus 14(5): 1-6, 2003.

Flannery TW, Suntharalingam M, Kwow Y, Koffman BH, Amin PP, Chin LS, Nicol B, Fowler, Young AB, Regine WF. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer, 42: 327-333, 2003.

Arnold SM, Regine WF, Ahmed MM, Valentino J, Spring P, Kudrimoti M, Kenady D, Desimone P, Mohiuddin M. Low-dose Fractionated Radiation as a Chemopotentiator of Neoadjuvant Paclitaxel and Carboplatin for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Results of a New Treatment Paradigm. Int J Radiat Oncol Biol Phys 58(5): 1411-1417, 2004.

Shehata MK, Young AB, Reid B, Patchell RA, St Clair W, Sims J, Sanders M, Meigooni AS, Mohiuddin M, Regine WF. Stereotatic Radiosurgery (SRS) of 468 Brain Metastases >2 cm: Implications for SRS Dose and Whole Brain Radiation Therapy (WBRT). Int J Radiation Oncology Biol Phys 59(1): 87-93, 2004.

Regine WF, Schmitt FA, Scott CB, Dearth C, Patchell RA, Nichols, RC, Gore EM, Franklin RL, Suh JH, Mehta MP. Feasibility of Neurocognitive Outcome Evaluations in Patients with Brain Metastases in a Multi-Institutional Cooperative Group Setting: Results of Radiation Therapy Oncology Group Trial BR-0018. Int J Radiation Oncology Biol Phys 58(5): 1346-1352, 2004.

Cheuk AV, Chin LS, Petit JH, Herman JM, Fang HB, Regine WF. Imaging Correlates of Gamma Knife Outcome in Trigeminal Neuraliga. Int. J Radiation Oncology Biol. Phys 60(2): 537-541, 2004.

Regine WF, Rogozinska A, Kryscio RJ, Tibbs PA, Young AB, Patchell RA. Recursive Partitioning Analysis Classifications I And II: Applicability Evaluated In A Randomized Trial For Resected Single Brain Metastases. Am J Clin Onc 27(5): 505-509, 2004.

Martin NE, Brunner TB, Kiel KD, DeLaney TF, Regine WF, Mohiuddin M, Rosato EF, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, Tanaka WK, Morrison B, Deutsch P, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ, Hahn SM. A Phase I Trial of the Dual Farnesyltransferase and Geranylgeranyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Pancreatic Cancer. Clinical Cancer Research, 10: 547- 554, 2004.

DiBiase SJ, Kwok Y, Yavino S, Arena C, Naqvi S, Temple R, Regine WF, Amin P, Guo C, Chin LS. Factors Predicting Local Tumor Control After Gamma Knife Stereotactic Radiosurgery for Benign Intracranial Meningiomas. Int J Radiation Oncology Biol Phys 60(5): 1515-1519, 2004.

Patchell R, Tibbs P, Regine WF, Payne R, Saris S, Kryscio R, Mohiuddin M, Young B. A randomized Trial of Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression caused by metastatic cancer. The Lancet 366: 643-648, 2005.

Gaugler J, Hanna N, Linder J, Given CW, Tolbert V, Kataria R, Regine WF. Cancer Caregiving and Subjective Stress: A Multi-Site Multi-Dimensional Analysis. Psycho-Oncology 14: 771-785, 2005.

Spring P, Valentino J, Arnold S, Sloan D, Kenady D, Kudrimoti M, Haydon RC, Lee C, Mohiuddin M, Regine WF. Long-Term Results of Hyperfractionated Radiation and High-Dose Intraarterial Cisplatin for Unresectable Oropharyngeal Carcinoma: Cancer, 104(8): 1765-1771, 2005.

Ma L, Kwok Y, Regine WF. Concomitant GRID Boost for Gamma Knife Radiosurgery: Med Phys 32(11): 3419-3423, 2005.

Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and Gamma Knife Radiosurgery for Trigeminal Neuralgia reatments: Phys. Med Biol. 50: 5217-5227, 2005.

Ha Jonathan, Zhang G, Naqvi SA, Regine WF, Yu CX. Feasibility of delivering grid therapy using a multileaf collimator: Med. Phys. 33(1): 76-82, 2006.

Thomas KC, Nosyk B, Fisher CG, Dvorak Marcel, Patchell RA, Regine WF, Loblaw A, Bansback N, Guh D, Sun Huiying, Anis A. Cost-Effectiveness of Surgery Plus Radiotherapy versus Radiotherapy Alone for Metastatic Epidural Spinal Cord Compression. Int. Journal Radiation Oncology Biol. Phys. 66(4): 1212-1218, 2006.

Huhn JL, Regine WF, Valentino J, Meigooni, AS, Kudrimoti M, Mohiuddin M. Spatially Fractionated GRID Radiation Treatment of Advanced Neck Disease Associated with Head and Neck Cancer. TCRT, 5(6): 607-610, December, 2006.

Regine WF, Hanna N, Ahmed M, Garofalo MC, DeSimone P, Arnold S, Mohiuddin M. Low-dose Radiation Therapy as a Chemopotentiator of Gemcitabine in Tumors of the Pancreas/small bowel - A Phase I Study Exploring a New Treatment Paradigm. Int. Journal Radiation Oncology Biol. Phys. 68 (1): 172-177, 2007.

D'Souza WD, Nazareth DP, Zhang B, DeYoung C, Suntharalingam M, Kwok Y, Yu Cx, Regine WF. The Use of Gated and 4D CT Imaging in Planning for Stereotactic Body Radition Therapy. Medical Dosimetry 32 (2): 92-101, 2007.

Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. Work, Gender and Stress in Family Cancer Cargiving. (In Press) Supportive Care in Cancer.

Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. The Proliferation of Primary Cancer Caregiving Stress to Secondary Stress. Cancer Nursing 31 (2) March/April 2008.

Balcer-Kubiczek EK, Attarpourl M, Wang Jiang Z, Regine WF. The Effect of Docetaxel (Taxotere®) on Human Gastric Cancer Cancer Cells Exhibiting Low-dose Radiation Hypersensitivity. Clinical Med Oncology (accepted, December 2007).




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