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Monica R. Shah, MD, MS, MHS

Academic Title:

Adjunct Professor

Primary Appointment:


Education and Training

BS: Brown University, Providence, RI

  • Duke University, Durham, NC (Health Sciences)
  • Columbia University Graduate School of Journalism, New York City, NY (Journalism)

MD: Brown University Medical School (Alpert Medical School), Providence, RI
Residency: Johns Hopkins Hospital, Baltimore, MD

  • Duke University Medical Center, Durham, NC
  • Duke Clinical Research Institute, Durham, NC
  • Brigham and Women’s Hospital, Boston, MA


Monica Shah is Vice President, Medical Strategy – Cardiovascular, at QuintilesIMS, the world's largest, global contract research organization. In her role at QuintilesIMS, she is responsible for the strategy, innovation, design, and implementation of large-scale cardiovascular clinical trials and studies. Dr. Shah is committed to collaboration, teamwork, communication and results-based strategic management to optimize clinical research and improve public health. She has a special interest in the science of operationalizing clinical trials, strategies to streamline studies and approaches to optimize enrollment, teamwork and collaboration in clinical research. Dr. Shah has extensive experience in developing, leading and executing complex, multidisciplinary research programs. Her areas of expertise include clinical trials, clinical research, cardiovascular disease, heart failure, cardiac transplantation, mechanical circulatory support and HIV-related cardiovascular disease.

Dr. Shah previously had a long career at the National Institutes of Health, where she was at the National Heart, Lung, and Blood Institute (NHLBI) and the National Center for Advancing Translational Sciences (NCATS). At NCATS, Dr. Shah was the director of the Trial Innovation Network in the Division of Clinical Innovation. In this role, she worked collaboratively with NCATS staff, the scientific community and other stakeholders to lead and manage the Trial Innovation Network.

Before joining NCATS, Dr. Shah was the deputy chief of the Heart Failure and Arrhythmias Branch at the National Heart, Lung, and Blood Institute (NHLBI). She also was the program officer for the NHLBI Heart Failure Clinical Research Network, and was at the forefront of using performance metrics and results-based accountability to optimize enrollment and scientific productivity in NHLBI programs. Dr. Shah also served as the NHLBI AIDS coordinator and championed the development of a national scientific portfolio on HIV-related heart, lung and blood disease.

Shah is a board-certified heart failure and transplant cardiologist. She completed her undergraduate education at Brown University and her medical education at the Brown University Medical School. She then completed a residency in internal medicine at the Johns Hopkins Hospital, and a fellowship in cardiology at Duke University Medical Center, where she received specialized training in clinical research at the Duke Clinical Research Institute. Dr. Shah also completed a fellowship in Heart Failure and Cardiac Transplantation at the Brigham and Women’s Hospital. Dr. Shah previously was an attending cardiologist and the director of Heart Failure Research at the Washington Hospital Center, and an attending cardiologist at Columbia University Medical Center and Duke University Medical Center. In addition to her medical training, Shah has a Masters in Health Sciences from Duke University and a Masters in Journalism from the Columbia University Graduate School of Journalism.

Research/Clinical Keywords

Cardiovascular clinical trials, heart failure clinical research, hiv-related heart, lung and blood disease

Highlighted Publications

Shah MR, Culp MA, Gersing KR, Jones PL, Purucker ME, Urv T, Wilson TM, and Kaufmann P. Early Vision for the CTSA Program Trial Innovation Network: A Perspective from the National Center for Advancing Translational Sciences. 8 March 2017; DOI: 10.1111/cts.12463.

Lewis GD, Malhotra R, Hernandez AF, McNulty SE, Smith A, Felker GM, Tang WHW, LaRue SJ, Redfield MM, Semigran MJ, Givertz MM, Van Buren P, Whellan D, Anstrom KJ, Shah MR, Desvigne-Nickens P, Butler J, Braunwald E; NHLBI Heart Failure Clinical Research Network. Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial. JAMA. 2017; 317:1958-1966.

Shah MR, Lauer MS. Striking the Right Balance in Heart Failure. Annals Int Med. Dec 22, 2015; doi:10.7326/M15-2587. PMID: 26720859

Redfield M, Anstrom K, Levine J, Koepp G, Borlaug B, Chen H, LeWinger M, Joseph S, Shah S, Semigran M, Felker GM, Cole R, Reeves G, Tedford R, Tang W, McNulty S, Velazquez E, Shah MR, Braunwald E. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. New Engl J Med. Nov 8, 2015; doi: 10.1056/NEJMoa1510774. PMID: 26549714

Shah MR, Wong R. The Changing Paradigm of HIV-Related Heart Failure. Global Heart. 2015. DOI: PMID: 26704962

Shah MR. The Broad Spectrum of HIV-Related Cardiovascular Disease. JACC Heart Failure. 2015; 8:600-02. PMID: 26164680