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Arshi Khanam, PhD

Academic Title:

Faculty Member

Primary Appointment:

Medicine

Additional Title:

Assistant Professor

Location:

725 W Lombard Street Baltimore

Phone (Primary):

410-706-1365

Education and Training

 Bachelors of Science, Biotechnology, Jiwaji University, Gwalior, India

 Master of Science, Biotechnology, Jiwaji University, Gwalior, India Master 

 Ph.D. Medicine, Faculty of Medical Sciences, University of Delhi,  New Delhi, India.

Jan 2013 - March 2013: Advanced training, Dept. of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

Research/Clinical Keywords

Liver Diseases, Viral hepatitis, Acute-on-Chronic Liver Failure, Immunology

Highlighted Publications

 

  1. Khanam A, Ghosh A, Chua JV, Kottilil S. Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways. J Transl Med. 2023 Apr 21;21(1):271. doi: 10.1186/s12967-023-04104-8. PMID: 37081509; PMCID: PMC10120209.
  2. Khanam A, Kottilil S. New Therapeutics for HCC: Does Tumor Immune Microenvironment Matter? International Journal of Molecular Sciences 2022. (ahead of print)
  3. Khanam A, Hector Gutierrez-Barbosa, Kirsten E Lyke, Joel V chua. Immune-Mediated Pathogenesis in Dengue Virus Infection. Viruses 2022 Nov 21;14(11):2575. doi: 10.3390/v14112575.
  4. Khanam A, Tang LSY, Kottilil S. Programmed death 1 Expressing CD8+CXCR5+ Follicular T Cells Constitute Effector Rather Than Exhaustive Phenotype in Patients with Chronic Hepatitis B. Hepatology. 2021 Oct 24. doi: 10.1002/hep.32210. Online ahead of print.
  5. Khanam A, and Shyam Kottilil. "Acute-on-Chronic Liver Failure: Pathophysiological Mechanisms and Management." Frontiers in Medicine: 2053. Front. Med., 08 November 2021 
  6. Khanam A,PG Saleeb, S Kottilil. Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured? Cells 2021,10 (5), 1097
  7. Khanam A,Natarajan A, Tang L, Poonia B, Kottilil S.  IL-21 deficient T follicular helper cell support B cell responses through Il-27 in patients with chronic hepatitis B. Front Immunol. 2021; 11:599648. doi: 10.3389/fimmu.2020.599648. eCollection 2020.
  8. Khanam A,JV Chua, S Kottilil. Immunopathology of Chronic Hepatitis B Infection: Role of Innate and Adaptive Immune Response in Disease Progression. International Journal of Molecular Sciences 2021, 22 (11), 5497
  9. Khanam A,Kottilil S. Abnormal innate immunity in acute-on-chronic liver failure: immunotargets for therapeutics. Front Immunol 2020; 11:2013
  10. Khanam A,Kottilil S, Wilson E. Reconstitution of T follicular helper-humoral immune axis with elimination of hepatitis C virus. Sci Rep. 2020;10(1):19924.
  11. Khanam A,Trehanpati N, Sarin SK. Increased Interleukin-23 Receptor (IL-23R) Expression is Associated with Disease Severity in Acute-on-Chronic Liver Failure. Liver International. 2019, 39(6):1063-1070
  12. Kim JH, Ghosh A, Ayithan N, Romani S, Khanam A,Park JJ, Rijnbrand R, Tang L, Sofia MJ, Kottilil S, Moore CB, Poonia B. Circulating serum HBsAg level is a biomarker for HBVspecific T and B cell responses in chronic hepatitis B patients. Sci Rep. 2020 Feb 4;10(1):1835. doi: 10.1038/s41598-020-58870-2.
  13. Kim JH, Ghosh A, Ayithan N, Romani S, Khanam A,Park JJ, Rijnbrand R, Tang L, Sofia MJ, Kottilil S, Moore CB, Poonia B. Publisher Correction: Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients. Sci Rep. 2020;10(1): 5947. doi: 10.1038/s41598-020-62445-6.
  14. Khanam A,Trehanpati N, Riese P, Rastogi A, Guzman CA, Sarin SK.Blockade of Neutrophil's Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Faiure. Front Immunol 2017, 24;8:464.
  15. Sehgal R, Patra S, David P, Vyas A, Khanam A, Hissar S, Gupta E, Kumar G, Kottilil S, Maiwal R, Sarin SK, Trehanpati N. Impaired monocyte - macrophage functions and defective tlr signalling in hepatitis e virus infected pregnant women with acute liver failure. Hepatology 2015; 62(6):1683-96.
  16. Trehanpati N, Sehgal R, Patra S, Vyas A, Vasudevan M, Khosla R, Khanam A, Kumar G, Maiwall R, Ramakrishna G, Kottilil S, Sarin SK. miRNA signatures can predict acute liver failure in hepatitis E infected pregnant female. Heliyon 2017 6;3(4): e00287.
  17. Khanam A,Trehanpati N, Garg V, Kumar C, Garg H, Sharma BC, Sarin SK. Altered Frequencies of Dendritic Cells and IFN-γ secreting T Cells with Granulocyte Colony Stimulating Factor Therapy in Acute-on-Chronic Liver Failure. Liver International 2014; 34:505-513.
  18. Kedarisetty CK, Anand L, Khanam A, Kumar G, Rastogi A, Maiwall R, Sarin SK Growth factors enhance liver regeneration in acute-on-chronic liver failure. Hepatol Int. 2014; 8:514-525.
  19. Trehanpati N, Khanam A, Hissar S, Sehgal R, Khosla R, David P, Kumar A, Parashar A, Bhardwaj A, Kottilil S, Sarin S K. Sequential Therapy with Tenofovir plus Peg Interferon Enhances Innate and Adaptive Immunity compared to Tenofovir monotherapy in chronic hepatitis B patients. J Clin Cell Immunol 2014; 5 (6):1000272.
  20. Garg V, Garg H, Khan A, Trehanpati N, Kumar A, Sharma BC, Sakhuja P, Sarin SK Granulocyte-Colony Stimulating Factor Mobilizes CD34+ Cells and improves Survival of Patients with Acute-On-Chronic Liver Failure. Gastroenterology. 2012; 142:505-512. 
  21. Trehanpati N, KottililS, Hissar S, Shrivastava S, Khanam A, Sukriti S, Mishra Sk, Sarin SK. Circulating Tregs correlate with viral load reduction in chronic HBV treated patients with Tenofovir disoproxil fumarate.J Clin Immunol. 2011; 31(3):509-20. 

Awards and Affiliations

  1. Awarded Young Investigator Travel award by AASLD conference held in Boston, Massachusetts, USA 2012.
  2. Best abstract award by AASLD conference held in Boston, Massachusetts, USA 2012.
  3. Awarded Gold Medal by Biotechnology Society of India for outstanding research work in the field of liver diseases. (2012)
  4. Awarded for oral presentation in Hepatology 360 Conference held in Vienna, Austria 2012.
  5. Awarded International Travel Grant by Hepatology 360 Conference held in Vienna, Austria 2012.
  6. Received International travel award to attend a workshop at Hepatology 360 Centers of excellence, New Castle, UK 2012.
  7. IG-SCID (Indo–German Science Centre for Infectious Disease) International Fellowship for research training in Germany by Indian Council of Medical Research (2012).
  8. Senior Research Fellowship by Indian Council of Medical Research (2012-2015)
  9. Best abstract award in Hepatology 360 conference held in Athens, Greece 2013.
  10. Awarded for best poster presentation in Hepatology 360 conference held in Athens, Greece 2013.
  11. International Travel Award by Hepatology 360 Conference held in Athens, Greece 2013.
  12. International Travel award from Department of Biotechnology (DBT)to attend American Association for Study of Liver Diseases (AASLD) conference held in Washington, DC, USA 2013.
  13. International Travel award from Department of Science and Technology (DST) to attend AASLD conference held in Washington, DC, USA 2013.
  14. Awarded the best oral presentation prize at Alcoholic Liver and Pancreatic Disease (ALPD) International conference held in Delhi, India 2013.
  15. Young investigator bursary by International Liver congress (ILC) held in Vienna, Austria 2015.
  16. Young investigator bursary by International Liver congress (ILC) held in Barcelona Spain 2016.
  17. Awarded for Oral presentation in 12th International Conference on Emerging Infectious Diseases held during 2021.