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Oliver H. Voss, PhD

Academic Title:

Research Associate

Primary Appointment:

Microbiology and Immunology

Additional Title:

Research Associate/Junior Faculty

Location:

685 W. Baltimore St. Baltimore, MD 21201

Phone (Primary):

410-706-3337

Fax:

410-706-0282

Education and Training

  • Lise-Meitner School (Germany); BS in Chemistry and Chemical-Technical Assistant (CTA), 1997
  • University of Applied Sciences (Germany); Graduate Engineer (Dipl.-Ing.), Biotechnology, 2002
  • The Ohio State University (Ohio); PhD, Molecular Genetics, 2010
  • The Ohio State University (Ohio); Post-Doctoral Fellow, Molecular Genetics, 2013
  • National Institutes of Health, Visiting Fellow, Receptor Cell Biology, LIG, NIAID, 2017

 

 

 

 

 

Research/Clinical Keywords

Monocytes, Macrophages, Inflammasome, Apoptosis, Autophagy, Caspases, TLR signaling, Rickettsia infection and other infectious diseases

Highlighted Publications

Voss, O.H., Murakami, Y., Pena, M.Y., Lee, H.N., Tian, L., Margulies, D.H., Street, J.M., Yuen, P., Qi, C.F., Krzewski, K. and Coligan, J.E. Lipopolysaccharide-induced binding of CD300b to Toll-like receptor 4 alters signaling to drive lethal cytokine responses that enhance septic shock. Immunity. 2016 doi:10.1016/j.immuni.2016.05.005

Malavez Y.*, Voss, O.H.*, González-Mejia, E.M., Parihar, A., and Doseff, A.I. Distinct contribution of protein kinase Cδ and protein kinase Cε in the lifespan and immune response of human blood monocyte subpopulations. Immunology. 2015 144:611-20.

Voss, O.H., Tian, L., Murakami, Y., Coligan, J.E., and Krzewski, K. Emerging role of CD300 receptors in regulating myeloid cell efferocytosis. Molecular & Cellular Oncology. 2015 2:4, e964625.

Murakami, Y., Tian, L., Voss, O.H., Margulies, D.H., Krzewski, K., and Coligan, J.E. CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition. Cell Death and Differentiation. 2014doi: 10.1038/cdd.2014.86.

Akhter, A., Caution, K., Abu Khweek, A., Tazi, M., Abdulrahman, B.A., Abdelaziz, D.H., Voss, O.H., Doseff, A.I., Hassan, H., Azad, A.K., Schlesinger, L.S., Wewers, M.D., Gavrilin, M.A., and Amer, A.O. Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. Immunity. 2012 37: 35-47.

González-Mejia, E.M.*, Voss, O.H.*, Murnan, E.J. and Doseff, A.I. Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27. Cell Death and Disease.2010 1, e64, doi:10.1038/cddis.2010.41.

Wood, K.*, Voss, O.H.*, Huang, Q., Parihar, A., Metha, N., Batra S. and Doseff, A.I. The small heat shock protein 27 is a key regulator of CD8+CD57+-lymphocyte survival. J. Immunol. 2010 184: 5582–5588. Selected for “In this issue” special editor’s commentary.

Voss, O.H.*, Batra S.*, Kolattukudy S.J., Gonzalez-Mejia M.E., Smith J.B. and Doseff A.I. Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation.  J. Biol. Chem. 2007 282: 25088-99.

Vargo, M.A., Voss, O.H., Cardounel, A.J., Grotewold, E. and Doseff, A.I. Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells.  Biochem. Pharmacol. 2006 72: 681-692.

Voss, O.H.*, Kim, S.*, Wewers, M.D. and Doseff, A.I. Caspase-3 is a phosphoprotein and associates with PKCδ during spontaneous monocyte apoptosis. J. Biol. Chem. 2005 280: 17371-17379.

*Shared equal first authorship

Awards and Affiliations

Patents

2016, Oliver H. Voss, Konrad Krzewski, and John E. Coligan. Use of CD300b antagonists to treat sepsis and septic shock. Inventors: U.S. Patent Application No. 62/308,144.