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Jeanine A. Ursitti, PhD

Academic Title:

Assistant Professor

Primary Appointment:



100 Penn Street

Education and Training

  • B.S., Biology, Loyola College, Baltimore, Maryland

  • Ph.D., Membrane Physiology, University of Maryland Baltimore, Baltimore, Maryland
  • Postdoctoral Fellowship, The Wistar Institute, Philadelphia, PA


Research/Clinical Keywords

membrane cytoskeleton, cardiovascular disease, hypertension

Highlighted Publications

Zhang, Y., W.G. Resneck, P.C. Lee, W.R. Randall, R.J. Bloch and J.A. Ursitti. 2010. Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat. J. Mol. Cell Cardiol. 48:1050-9.

Ursitti, J.A., B.G. Petrich, P.C. Lee,X. Ye, J. Yang, W.R. Randall, R.J. Bloch, and Y. Wang. 2007. Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase. J Mol Cell Cardiol. 42:572-81.

Ursitti, J.A., P.C. Lee, W.G. Resneck, M.M. McNally, A.L. Bowman, A. O'Neill, M.R. Stone, R.J. Bloch. 2004. Cloning and Characterization of Cytokeratins 8 and 19 in Adult Rat Striated Muscle: Interaction with the dystrophin glycoprotein complex.  J. Biol. Chem. 279:41830-41838.



Additional Publication Citations

Pumplin, D.W., P.W. Luther, S.J. Samuelsson, J.A. Ursitti, and J. Strong. 1989. Quick-freeze, deep-etch, replication of cells in monolayers. Journal of Electron Microscopy Technique. 14:342-347.

Ursitti, J.A., D.W. Pumplin, J.B. Wade, and R.J. Bloch. 1991. Ultrastructure of the human erythrocyte cytoskeleton and its attachment to the membrane. Cell Motility and the Cytoskeleton. 19:227-243.

Speicher, D.W., T.M. DeSilva, K.D. Speicher, J.A. Ursitti, P. Hembach, and L. Weglarz. 1992. Location of the human red cell spectrin tetramer binding site and detection of a related "closed" hairpin loop dimer using proteolytic footprinting. J. Biol. Chem. 268:4227-4235.

Ursitti, J.A. and J.B. Wade. 1993. Ultrastructure and immunocytochemistry of the isolated human erythrocyte membrane skeleton. Cell Motility and the Cytoskeleton. 25:30-42.

Speicher, D.W. and J.A. Ursitti. 1994. Conformation of a mammoth protein. Current Biology. 4:154-157.

Ursitti, J.A. and V.M. Fowler. 1994. Immunolocalization of tropomodulin, tropomyosin, and actin in spread human erythrocyte skeletons. J. Cell Sci. 107:1633-1639.

Ursitti, J.A., L. Kotula, T.M. DeSilva, P. Curtis and D.W. Speicher. 1996. Mapping the erythrocyte β-spectrin dimer initiation site using recombinant peptides and correlation of its phasing with the α-actinin dimer site. J. Biol. Chem. 271:6636-6644.

Wilmotte, R., S.L. Harper, J.A. Ursitti, J. Marechal, J. Delaunay, and D.W. Speicher. 1997. The exon 46-encoded sequence is essential for stability of human erythroid α-spectrin and heterodimer formation. Blood. 90:4188-4196.

Zhou, D., J.A. Ursitti, and R.J. Bloch. 1998. Developmental expression of spectrins in rat skeletal muscle. Mol.Biol.Cell. 9:47-61.

Williams, M.W., W.G. Resneck, J.A. Ursitti, T. Kaysser, C.S. Birkenmeier, J.E. Barker, and R.J. Bloch. 2001. Na,K-ATPase in skeletal muscle: Two populations of b-spectrin control localization in the sarcolemma but not partitioning between the sarcolemma and transverse tubules. J.Cell Sci. 114:751-762.

Ursitti, J.A., L. Martin, W.G. Resneck, T. Chaney, C. Zeilke, B.E. Alger, and R.J. Bloch. 2001. Spectrins in developing rat hippocampal cells. Devel. Brain Res. 129:81-93.

Bloch R.J., Y. Capetanaki, A. O'Neill, P. Reed, M.W. Williams, W.G. Resneck, N.C. Porter, J.A. Ursitti. 2002. Costameres: repeating structures at the sarcolemma of skeletal muscle. Clin. Orthop. 403:S203-10.               

Zheng, M. K. Dilly, J. Dos Santos Cruz, M. Li, Y. Gu, J.A. Ursitti, J. Chen, J. Ross Jr., K.R. Chien, W.J. Lederer, Y. Wang. 2004. Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. Am. J. Physiol. Heart Circ. Physiol. 286:H424-33.

Stone, M.R., A. O'Neill, R.M. Lovering, J. Strong, W.G. Resneck, P.W. Reed, D.M. Toivola, J.A. Ursitti, M.B. Omary and R.J. Bloch. 2007. Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization. J. Cell Sci. 120:3999-4008.

Antolik, C., D.H. Catino, A.M. O’Neill, W.G. Resneck, J.A. Ursitti and R.J. Bloch. 2007. The actin binding domain of ACF7 binds directly to the tetratricopeptide repeat domains of rapsyn. Neuroscience. 145:56-65.

Benz, P.M., C.J. Merkel, K. Offner, M. Abener, M. Ullrich, T. Fischer, B. Bayer, H. Wagner, S. Gambaryan, J.A. Ursitti, U.M. Adham, W.A. Linke, S.M. Feller, I. Fleming, T. Renne, S. Frantz, A. Unger, K. Schuh. 2013.  Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.Cell Commun. Signal.11:56.