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Jason Kyle Molitoris, MD, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Radiation Oncology

Additional Title:

Assistant Professor, Department of Radiation Oncology

Location:

Ground Floor - Department of Radiation Oncology

Phone (Primary):

410-328-2328

Fax:

410-328-6911

Education and Training

University of Maryland Medical Center; Baltimore, MD
Resident Physician
Chief Resident
Department of Radiation Oncology
Maryland Proton Treatment Center
Marlene and Stewart Greenebaum Comprehensive Cancer Center

Greater Baltimore Medical Center; Baltimore, MD
Internship
Department of Internal Medicine

Case Western Reserve University School of Medicine; Cleveland, OH
Doctor of Medicine
Alpha Omega Alpha

Doctor of Philosophy
Medical Scientist Training Program

The College of William and Mary; Williamsburg, VA
Bachelor of Science, Biology
Summa cum laude
Phi Beta Kappa

Biosketch

Dr. Jason K. Molitoris is an Assistant Professor in the Department of Radiation Oncology at the University of Maryland. His primary areas of clinical and research interest include genitourinary, gastrointestinal, central nervous system and hemato-lymphoid malignancies.

Dr. Molitoris completed his undergraduate studies at The College of William and Mary with a BS in Biology and subsequently graduated from the dual degree M.D./Ph.D Medical Scientist Training Program at Case Western Reserve University. His dissertation focused on the abnormal regulation of cell death in leukemia and lymphoma.

After a medicine internship at Greater Baltimore Medical Center, Dr. Molitoris completed his residency training in Radiation Oncology at the University of Maryland Medical Center, serving as Chief Resident. While a resident he maintained his interest in basic science by applying his knowledge to novel mechanisms of radiosensitization. He also became interested in clinical trial development and attended the AACR/ASCO clinical trials workshop in Vail Colorado during his final year of residency.

Dr. Molitoris’ ongoing research at the University of Maryland is focused on implementation of advanced treatment technologies to his clinical areas of interest and evaluating novel approaches to improve treatment efficacy while decreasing side effects. He is interested in utilizing multiple advanced treatment technologies, including proton therapy, brachytherapy, thermal therapy. Dr. Molitoris has multiple peer-reviewed publications from both his basic science and clinical research. He has given many national/international presentations on his work and received awards for his presentations and including from The American Radium Society, International Congress for Hyperthermic Oncology, and the Radiological Society of North America Roentgen Resident/Fellow Research Award.

Overall, Dr. Molitoris strives to provide excellent clinical care in a team-based approach within the Marlene and Stewart Greenebaum Comprehensive Cancer Center while advancing the field of radiation through implementation of novel technologies and translational research.

Research/Clinical Keywords

Prostate cancer, Gastrointestinal Cancers, Lymphoma, Brachytherapy, Hyperthermia

Highlighted Publications

Molitoris JK, Rao YJ, Patel RA, Kane LT, Badiyan SN, Gittleman HR, Barnholtz-Sloan J, Bentzen SM, Kruser TJ, Huang J, Mehta MP. Multi-institutional Validation of a Novel Glioblastoma Prognostic Nomogram Incorporating MGMT Methylation. Journal of Neuro-Oncology. 2017. 134(2):331-338.

Vyfhuis MAL, Bhooshan N, Molitoris JK, Bentzen SM, Feliciano J, Edelman M, Burrows WM, Nichols EM, Suntharalingam M, Donahue J, Nagib M, Carr SR, Friedberg J, Badiyan S, Simone CB II, Feigenberg SJ, Mohindra P.  Clinical outcomes of black vs. non-black patients with locally advanced non-small cell lung cancer. Lung Cancer. 2017. 114:44-49.

Molitoris JK, Diwanji T, Snider JW, Bellavance EC, Kesmodel SB, Rosenblatt P, Tkaczuk K, Bentzen SM, Cohen RJ, Nichols EM, Cheston SB, Feigenberg SJ. Regional Nodal Irradiation in Elderly Node Positive Women: A Patterns of Care Study on Changes in Utilization over a Decade. Breast Cancer Res Treat. 2017. 165(3):669-676.

Sperduto PW, Jiang W, Brown PD, Braunstein SE, Sneed PK, Wattson DA, Shih HA, Bangdiwala A, Shanley R, Lockney NA, Beal K, Lou E, Amatruda T, Sperduto WA, Kirkpatrick JP, Yeh N, Gaspar LE, Molitoris JK, Masucci L, Roberge D, Yu JB, Chiang VL, Mehta MP. The Effect of Targeted Therapies on Prognostic Factors, Patterns of Care and Survival in Patients with Renal Cell Carcinoma and Brain Metastases. Int J Radiat Oncol Biol Phys. 2018.

Molitoris JK, Diwanji T, Snider JW, Mossahebi S, Samanta S, Badiyan SN, Simone CB 2nd, Mohindra P. Advances in the Use of Motion Management and Image Guidance in Radiation Therapy Treatment for Lung Cancer. Journal of Thoracic Disease. 2018.

Additional Publication Citations

Li S, Yamauchi A, Marchal CC, Molitoris JK, Quilliam LA, Dinauer MC. Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. J Immunol. 2002. 169(9):5043-51.

Yamauchi A, Marchal CC, Molitoris JK, Pech N, Knaus U, Towe J, Atkinson SJ, Dinauer MC. Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. J Biol Chem. 2005. 280(2):953-64.

Harr MW, McColl KS, Zhong F, Molitoris JK, Distelhorst CW. Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes. Autophagy. 2010. 6(7):912-21.

Zhong F, Harr HW, Bultynck G, Monaco G, Parys JB, De Smedt H, Rong Y, Molitoris JK, Ryder C, Matsuyama, S, Distelhorst CW. Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction. Blood. 2011. 117(10):2924-34.

Molitoris JK, McColl KS, Distelhorst CW. Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis. Mol Endocrinol. 2011. 25(3):409-20.

Molitoris JK, McColl KS, Swerdlow S, Matsuyama M, Lam M, Finkel TH, Matsuyama S, Distelhorst CW. Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes. J Biol Chem. 2011. 286(34):30181-9.

Starnes AM, Jou PC, Molitoris JK, Lam M, Baron ED, Garcia-Zuazaga J. Acute Effects of Fractional Laser on Photo-Aged Skin. Dermatol Surg. 2012. 38(1):51-7.

D’Emic N, Engelman A, Molitoris JK, Hanlon A, Sharma N, Moeslein F, Chuong MD. Prognostic significance of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in patients treated with selective internal radiation therapy. J Gastrointest Oncol. 2016. 7(2):269-77.

Mahmood J, Shamah A, Creed M, Pavlovic R, Matsui H, Kimura M, Molitoris JK, Shukla H, Jackson IL, Vujaskovic Z. Radiation Induced Erectile Dysfunction: Recent Advances and Future Directions. Advances in Radiation Oncology. 2016. 1(3):161-169.

Badiyan SN, Molitoris JK, Regine W; Chuong MD; Kaiser A. The Role of Radiation Therapy for Pancreatic Cancer in the Adjuvant and Neoadjuvant Settings. Surg Oncol Clin N Am. 2017. 26(3): 431-453.

Sperduto PW, Jiang W, Brown PD, Braunstein SE, Sneed PK, Wattson DA, Shih HA, Bangdiwala A, Shanley R, Lockney NA, Beal K, Lou E, Amatruda T, Sperduto WA, Kirkpatrick JP, Yeh N, Gaspar LE, Molitoris JK, Masucci L, Roberge D, Yu JB, Chiang VL, Mehta MP. The Prognostic Value of BRAF, cKIT and NRAS Mutations in Melanoma Patients with Brain Metastases. Int J Radiat Oncol Biol Phys. 2017. 98(5):1069-1077.

Sperduto PW, Jiang W, Brown PD, Braunstein SE, Sneed PK, Wattson DA, Shih HA, Bangdiwala A, Shanley R, Lockney NA, Beal K, Lou E, Amatruda T, Sperduto WA, Kirkpatrick JP, Yeh N, Gaspar LE, Molitoris JK, Masucci L, Roberge D, Yu JB, Chiang VL, Mehta MP. Estimating Survival in Melanoma Patients with Brain Metastases: An Update of the Graded Prognostic Assessment for Melanoma Using Molecular Markers (Melanoma-molGPA). Int J Radiat Oncol Biol Phys. 2017. 99(4):812-816.

Diwanji T, Molitoris JK, Chhabra A, Bentzen SM, Tkaczuk K, Rosenblatt P, Kesmodel SB, Bellavance EC, Nichols EM, Feigenberg SJ. Utilization of Hypofractionated Whole-Breast Radiation Therapy in Patients Receiving Chemotherapy: A National Cancer Database Analysis. Breast Cancer Res Treat. 2017. 165(2):445-453.

Molitoris JK, Diwanji T, Samanta S, Lamichhane N, Chhabra A, Roque D, Rao G, Amin P, Nichols EM, Mohindra P. Improving Outcomes through Immune System Modulation in the Treatment of Gynecological Malignancies. Rep Imm: Open Access. 2017. 2(34).

Molitoris JK, Chhabra A, Snider JW, Harvilla N, Okonkwo N, Nichols EM, Vujaskovic Z, Ioffe OB, Kesmodel SB, Feigenberg SJ. Intensification of Treatment for Angiosarcoma of the Breast with Accelerated Hyperfractionated Radiation, Hyperthermia and Surgical Resection. Cureus. 2017. 9(6): e1406.

Hessler LK, Molitoris JK, Rosenblatt P, Bellavance EC, Nichols EM, Tkaczuk KH, Feigenberg SJ, Bentzen SM, Kesmodel SB. Factors Influencing Management and Outcome in Patients with Occult Breast Cancer with Axillary Lymph Node Involvement: Analysis of the National Cancer Database. Annals of Surgical Oncology. 2017. 24(10):2907-2914. (Co-first author)

 

Badiyan SN, Molitoris JK, Zhu M, Glass E, Diwanji T, Simone CB II. Proton Beam Therapy for Malignant Pleural Mesothelioma. Transl Lung Cancer Res. 2018. 7(2):189-198.

Molitoris JK, Diwanji T, Snider JW, Mossahebi S, Samanta S, Badiyan SN, Simone CB 2nd, Mohindra P. Advances in the Use of Motion Management and Image Guidance in Radiation Therapy Treatment for Lung Cancer. Journal of Thoracic Disease. 2018. In Press.

Research Interests

Dr. Molitoris’ ongoing research at the University of Maryland is focused on implementation of advanced treatment technologies to his clinical areas of interest and evaluating novel approaches to improve treatment efficacy while decreasing side effects. He is interested in utilizing multiple advanced treatment technologies, including proton therapy, brachytherapy, thermal therapy. Dr. Molitoris has multiple peer-reviewed publications from both his basic science and clinical research. He has given many national/international presentations on his work and received awards for his presentations and including from The American Radium Society, International Congress for Hyperthermic Oncology, and the Radiological Society of North America Roentgen Resident/Fellow Research Award.

Awards and Affiliations

Scholar Award: Lynn Sage Breast Cancer Symposium

Chief Resident: Department of Radiation Oncology, University of Maryland Medical Center

New Investigator Travel Award: International Congress for Hyperthermic Oncology

Travel Grant Award: American Radium Society Annual Meeting, awarded for top abstract submissions

Research Fellow: ASCO/AACR Workshop on Methods in Clinical Cancer

Nominee: H.E.R.O. Healthcare Excellence in Radiation Oncology Award, University of Maryland Medical Center

Travel Grant Award: ASTRO Advocacy Day

Roentgen Resident/Fellow Award: Radiological Society of North America