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Anthony J. Kim, PhD

Academic Title:

Associate Professor

Primary Appointment:

Neurosurgery

Secondary Appointment(s):

Pharmacology

Additional Title:

Co-Director of Translational Therapeutics Research Group; Adjunct Associate Professor of Pharmaceutical Sciences (School of Pharmacy) and Chemical, Biochemical, & Environmental Engineering (UMBC)

Location:

655 West Baltimore Street, 8-029 Bressler Research Building

Phone (Primary):

410-706-3255

Fax:

410-706-7907

Education and Training

B.S., Chemical Engineering, Pennsylvania State University, 2001

Ph.D., Chemical and Biomolecular Engineering, University of Pennsylvania, 2006

Postdoctoral Fellow, Bioengineering, University of Pennsylvania, 2007-2009

Postdoctoral Fellow, Johns Hopkins University School of Medicine, 2009-2013 

 

Biosketch

Anthony Kim is an Associate Professor of Neurosurgery and Pharmacology at the University of Maryland School of Medicine.  Dr. Kim received his undergraduate degree in Chemical Engineering at Pennsylvania State University and Ph.D. from the University of Pennsylvania in the Department of Chemical and Biomolecular Engineering.  He then completed his postdoctoral training as an individual NIH National Research Service Award (NRSA) postdoctoral fellow at the University of Pennsylvania and Johns Hopkins University School of Medicine. Dr. Kim joined the faculty of the University of Maryland School of Medicine as a tenure-track Assistant Professor in April 2013. 

As the Director of the Therapeutic Bioengineering Laboratory and Co-Director of the Translational Therapeutics Research Group (TTRG), Dr. Kim's research focuses on developing translational nanomedicine for brain, breast, and other cancers.  This is achieved through a collaborative team of engineers, basic scientists, and clinicians to spur innovation at the interface of bioengineering and clinical medicine.  Towards this goal, his team will (1) identify and characterize the rate-limiting extra- and intracellular barriers by applying innovative biophysical tools and (2) develop advanced therapeutic platforms that overcome these barriers to improve therapeutic outcomes. Dr. Kim has authored 38 peer-reviewed papers, including publications in Nature MaterialsScience, Angewandte ChemieJournal of the American Chemical SocietyPhysical Review Letters, and Biomaterials. His research program has been supported by the National Institutes of Health (NIH), National Science Foundation (NSF), American Cancer Society (ACS), Elsa U. Pardee Foundation, AAPS Foundation, and PhRMA Foundation.

 

Selected Honors and Awards:

Maryland Innovation Initiative Award, 2019

NIH MERIT Award (R37), 2018

NIH K25 Quantitative Research Career Development Award, 2014-2017

AAPS New Investigator Award, American Association of Pharmaceutical Scientists, 2015    

Genentech/AAPS Innovation in Biotechnology Award, 2015

PhRMA Foundation Research Starter Grant in Pharmaceutics, 2014

NIH F32 NRSA individual Postdoctoral Fellowship, 2011-2013

 

Highlighted Publications

Wadajkar AS, Dancy JG, Carney CC, Hampton B, Ames H, Winkles JA, Woodworth GF, Kim AJ. (2019) Leveraging Surface Plasmon Resonance to Dissect the Interfacial Properties of Nanoparticles: Implications for tissue binding and tumor penetration. Nanomedicine: Nanotechnology, Biology, and Medicine 20, 102024.

Wadajkar AS, Dancy JG, Roberts NR, Connolly N, Strickland DK, Winkles JA, Woodworth GF, Kim AJ. (2017) Decreased non-specific adhesivity, receptor targeted (DART) nanoparticles exhibit improved dispersion, cellular uptake, and tumor retention in invasive gliomas. Journal of Controlled Release 267, 144. 

Hersh DS, Nguyen BA, Dancy JG, Adapa AR, Winkles JA, Woodworth GF, Kim AJ, Frenkel V. (2016) Pulsed ultrasound non-destructively expands the extracellular and perivascular spaces of the brain. Brain Research 1646, 543.

Dancy JG, Wadajkar AS, Schneider CS, Mauban JRH, Goloubeva OG, Woodworth GF, Winkles JA, Kim AJ. (2016) Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue. Journal of Controlled Release 238, 139.

Schneider CS, Bhargav A, Perez JG, Wadajkar A, Winkles JA, Woodworth GF, Kim AJ. (2015) Surface plasmon resonance as a high throughput method to evaluate specific and nonspecific binding of nanotherapeutics. Journal of Controlled Release. 219, 331.

Schneider CS, Perez JG, Cheng E, Zhang C, Panagiotis M, Hanes J, Winkles JA, Woodworth GF, Kim AJ. (2015) Minimizing the Non-specific Binding of Nanoparticles to the Brain Enables Active Targeting of Fn14-positive Glioblastoma Cells. Biomaterials. 42, 42.

Kim AJ, Boylan NJ, Suk JS, Hwangbo M, Yu T, Shuster BS, Cebotaru L, Lesniak, WG, Oh JS, Adstamongkonkul P, Choi AY, Kannan RM, Hanes J. (2013) Use of Single-Site Functional PEG-Dendrons to Prepare Gene Vectors that Penetrate Human Mucus Barriers. Angewandte Chemie Int Ed. 52, 3985.

Kim AJ, Scarlett R, Biancaniello PL, Sinno TR, Crocker JC. (2009) Probing interfacial equilibration in microsphere crystals formed by DNA-directed assembly. Nature Materials. 8, 52.

Kim AJ, Manoharan VN, Crocker JC. (2005) Swelling-Based Method for Preparing Stable, Functionalized Polymer Colloids. Journal of the American Chemical Society. 127, 1592.

Additional Publication Citations

Hersh DS, Harder BG, Roos A, Peng S, Heath JE, Legesse T, Kim AJ, Woodworth GF, Tran NL, Winkles JA. (2018) The TNF Receptor Family Member Fn14 is Highly Expressed in Recurrent Glioblastoma (GBM) and in GBM Patient-Derived Xenografts With Acquired Temozolomide Resistance. Neuro-Oncology (In Press)

Hersh D, Anastasiadis P, Mohammadabadi A, Nguyen BA, Guo S, Winkles JA, Kim AJ, Gullapalli RP, Keller A, Frenkel V, Woodworth GF. (2018) MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain. PLoS ONE. 13, e0192240 .

Connolly N, Shetty A, Stokum J, Hoeschele I, Siegel M, Miller CR, Kim AJ, Ho C, Davila E, Simard JM, Devine S, Rossmeisl J, Holland E, Winkles J, Woodworth GF. (2018) Cross-species transcriptional analysis reveals conserved and host-specific neoplastic processes in mammalian glioma. Scientific Reports. 8, 1180.

Wadajkar AS, Dancy JG, Hersh DS, Anastasiadis P, Tran NL, Woodworth GF, Winkles JA, Kim AJ. (2017) Tumor-targeted nanotherapeutics: overcoming treatment barriers for glioblastoma. WIREs Nanomedicine & Nanobiotechnology 9:e1439 (Invited Review).

Hersh DS, Wadajkar AS, Roberts NB, Perez JG, Connolly NP, Frenkel V, Winkles JA, Woodworth GF, Kim AJ. (2016). Evolving drug delivery strategies to overcome the blood brain barrier. Current Pharmaceutical Design 22, 1177 (Invited Review).

Roberts NB*, Wadajkar AS*, Winkles JA, Davila E, Kim AJ, Woodworth GF. (2016) Repurposing platinum-based chemotherapies for multi-modal treatment of glioblastoma. OncoImmunology. 5, e1208876.​

Perez JG, Tran NL, Rosenblum MG, Schneider CS, Connolly NP, Kim AJ, Woodworth GF, Winkles JA (2016). The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics. Oncogene​ 35, 2145.

Hersh DS, Kim AJ, Winkles JA, Eisenberg HE, Woodworth GF, Frenkel V. (2016) Emerging applications of therapeutic ultrasound in neuro-oncology: Moving beyond tumor ablation. Neurosurgery. 79, 643.

Kim AJ*, Woodworth GF*, Boylan NJ, Suk JS, Hanes J. (2014) Highly compacted pH-responsive DNA nanoparticles mediate transgene silencing in experimental glioma. Journal of Materials Chemistry B. 2, 8165.

Schuster BS, Kim AJ, Kays JC, Kanzawa MM, Suk JS, Hanes J. (2014) The cystic fibrosis sputum barrier to adeno-associated virus gene therapy. Molecular Therapy. 22, 1484.

Pan-in P, Wanichwecharungruang S, Hanes J, Kim AJ. (2014) Cellular trafficking and anticancer activity of Garcinia mangostana extract-encapsulated polymeric nanoparticles. International Journal of Nanomedicine. 9, 3677.

Pease M, Oglesby EN, Cone-Kimball E, Jefferys JL, Steinhart MR, Kim AJ, Hanes J, Quigley HS. (2014) Scleral Permeability Varies by Mouse Strain and Is Decreased by Chronic Experimental Glaucoma. Investigative Ophthalmology & Visual Science. 55, 2564.

Suk JS*, Kim AJ*, Trehan K, Schneider CS, Cebotaru L, Woodward OM, Boylan NJ, Boyle MP, Lai SK, Guggino WB, Hanes J. (2014) Lung Gene Therapy with Highly Compacted DNA Nanoparticles that Overcome the Mucus Barrier. Journal of Controlled Release. 178, 8.

Kim AJ*, Boylan NJ*, Suk JS, Lai SK, Hanes J. (2012) Non-degradative Intracellular Trafficking of Highly Compacted Polymeric DNA Nanoparticles. Journal of Controlled Release. 158, 102. 

Burke CW, Suk JS, Kim AJ, Hsiang YJ, Klibanov AL, Hanes J, Price RJ. (2012) Markedly Enhanced Skeletal Muscle Transfection Achieved by the Delivery of Non-Viral Gene Nanocarriers with Small Microbubbles and Pulsed 1 MHz Ultrasound. Journal of Controlled Release. 162, 414.

Boylan NJ*, Kim AJ*, Suk JS, Adstamongkonkul P, Simons BW, Lai SK, Cooper MJ, Hanes J. (2012) Enhancement of airway gene transfer by DNA Nanoparticles using a  pH-Responsive block copolymer of polyethylene glycol and poly-l-lysine. Biomaterials.  33, 2361.

Kim AJ#, Hanes J#. (2012) The emergence of multiple particle tracking in intracellular trafficking of nanomedicines. Biophysical Reviews. 4, 83.

Percec V, Wilson DA, Leowanawat P, Wilson CJ, Hughes AD, Kaucher MS, Hammer DA, Levine DH, Kim AJ, Bates FS, Davis KP, Lodge TP, Klein ML, DeVane RH, Aqad E, Rosen BM, Argintaru AO, Sienkowska MJ, Rissanen K, Nummelin S, Ropponen J. (2010) Self-Assembly of Janus-Dendrimers into Monodisperse Dendrosomes and other Complex Architectures. Science. 328, 1009.

Kim AJ, Kaucher MS, Davis KP, Peterca M, Iman MR, Christian NA, Levine DH, Bates FS, Percec V, Hammer DA. (2009) Proton Transport through Dendritic Helical Pore incorporated Polymersomes. Advanced Functional Materials. 19, 2930.

Biancaniello PL, Kim AJ, Crocker JC. (2008) Long-time stretched exponential kinetics in the single DNA duplex dissociation. Biophysical Journal. 94, 891.

Kaucher MS, Dulcey AE, Peterca M, Kim AJ, Vinogradov SA, Hammer DA, Heiney PA, Percec V. (2007) Selective Transport of Water Mediated by Porous Dendritic Dipeptide. Journal of the American Chemical Society. 129, 11698.

Moon JH, Kim AJ, Crocker JC, Yang S. (2007) High-throughput synthesis of anisotropic colloids via holographic lithography. Advanced Materials. 19, 2508.

Kim AJ, Biancaniello PL, Crocker JC. (2006) Engineering DNA-mediated Colloidal Crystallization. Langmuir. 22, 1991.

Biancaniello PL, Kim AJ, Crocker JC. (2005) Colloidal Interactions and Self-Assembly Using DNA Hybridization. Physical Review Letters. 94, 58302.

Awards and Affiliations

Selected Honors and Awards:

Maryland Innovation Initiative Award, TEDCO, 2019

Collaborative MPI Program Award, University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC), 2019

Accelerated Translational Project Award, Institute for Clinical and Translational Research, 2019

NIH MERIT Award (R37), 2018

Cigarette Restitution Fund (CRF) Pilot Grant Award, University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC), 2018

Guest Editor, Journal of Controlled Release, 2017

Collaborative MPI Program Award, University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC), 2017

NIH K25 Quantitative Research Career Development Award, 2014-2017 

Pilot Research Grant Award, University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC), 2016

AAPS New Investigator Award, American Association of Pharmaceutical Scientists, 2015    

AAPS Innovation in Biotechnology Award (sponsored by Genentech), American Association of Pharmaceutical Scientists, 2015

PhRMA Foundation Research Starter Grant in Pharmaceutics, 2014

American Cancer Society (ACS) Institutional Research Grant, 2014

NIH F32 NRSA individual Postdoctoral Fellowship, 2011-2013

Wilmer Research Award, 2012

 

Professional Affiliations:

Controlled Release Society (CRS)

American Association of Pharmaceutical Scientists (AAPS)

Biomedical Engineering Society (BMES)

American Institute of Chemical Engineers (AICHE)

American Association of Cancer Research (AACR)

Grants and Contracts

 

NIH R01/R37 CA218617 (Role: PI), Impact of Fn14-targeted Nanoparticles for Triple-Negative Breast Cancer, 03/01/18 – 02/28/25

 

NIH R01 NS107813 (Role: Co-I), Nanotherapeutic treatment of the invasive glioblastoma microenvironment04/01/19 – 03/31/24

 

UMGCC Collaborative MPI Program Award (Role: MPI), Enhancing immunotherapy of metastatic triple-negative breast cancer using tumor/macrophage targeting nanoparticles, 07/01/19 – 06/31/21 

 

Maryland Innovation Initiative Award (Role: MPI), Development of the DART Therapeutic Nanoparticle Platform for Fn14-Positive Cancers, 09/01/19 – 06/31/20

 

ATIP Innovative Collaborative Project Award (Role: MPI), Repurposing Metformin using DART Nanoparticle Technology for Treatment of Head and Neck Squamous Cell Carcinoma, 07/01/19 – 6/31/20

 

American Cancer Society Research Scholar Grant (Role: Co-I), Fn14-targeted Biodegradable BCNU Nanoparticles for Invasive Brain Tumors, 07/01/16 – 06/31/20

 

UMB ICTR Pilot Grant (Role: PI), Investigation of DART Nano-Drug Formulation Strategy for Improved Treatment of Breast Cancer Brain Metastases, 02/01/19 – 01/31/20 

 

UMGCC CRF Pilot Grant (Role: MPI), Identification of TWEAK/Fn14 signaling nodes of vulnerability for improved treatment of glioblastoma, 07/01/18 – 6/31/19

 

UMGCC Collaborative MPI Program Award (Role: MPI), Pulsed Focused Ultrasound and Tumor-penetrating, Fn14-targeted Nanotherapeutics for the Treatment of Head and Neck Squamous Cell Carcinoma, 07/01/17 – 06/31/19 

 

Completed Grants:

NIH K25 EB018370 (Role: PI), Fn14-targeted Therapeutics for Invasive Brain Cancer, 09/01/14 – 08/31/17

 

NSF EAGER CBET - 1557922 (Role: Co-PI), Effect of pulsed focused ultrasound on microstructures in the brain, 07/01/16 – 06/31/17   

 

UMGCC Pilot Research Grant (Role: MPI), Focused-Ultrasound Mediated Blood Brain Barrier Disruption for Improved Therapeutic Delivery to Invasive Brain Cancer, 07/01/16 – 06/31/17

 

Elsa U. Pardee Foundation Cancer Research Grant (Role: PI), Fn14-targeted Brain Penetrating Nanotherapeutics for Glioblastoma, 07/01/15 – 07/01/16

 

AAPS Foundation New Investigator Grant (Role: PI), Novel Therapeutic Strategies to Target Invasive Brain Cancer, 07/01/15 – 07/01/16

 

American Cancer Society Institutional Research Grant (Role: PI), Fn14-targeted Nanotherapeutics for Glioblastoma: Distribution, Pharmacokinetics, and Efficacy Studies, 01/01/15 – 01/01/16  

 

PhRMA Foundation Research Starter Grant in Pharmaceutics (Role: PI), Fn14-targeted Therapeutics for Invasive Brain Cancer, 01/15/14 – 01/15/15

 

NIH F32 HL103137 (Role: PI), Design of Non-Viral Gene Carriers that Overcome Extra- and Intracellular Barriers, 08/29/11 – 08/29/13

 

Wilmer Research Grant (Role: PI), Intracellular Fate of Nanoparticles Designed for Gene Therapy, 10/01/12 – 10/01/13               

Links of Interest