Xiaofeng Jia, BM, PhD

Selected since 2006

1. Wang Z, Zhang S, Chen S, Lachance BB, Du J, Polster B, Jia X*. Neuroprotection of NSC Therapy is Superior to Glibenclamide in Cardiac Arrest Induced Brain Injury via Neuroinflammation Regulation. Transl Stroke Res. 2022 Aug 3. doi: 10.1007/s12975-022-01047-y. Online ahead of print. PMID: 35921049
2. Wang Z, Jia X. Treating peripheral nerve injury-induced spinal cord degeneration and neuropathic pain with peripherally administrated stem cells. Neural Regeneration Research. June 02, 2022, doi: 10.4103/1673-5374.346491
3. Xu X, Zhou X, Du J, Lachance BB, Jia X. The hyperinflammatory state induced by the senescence of macrophages impairs recovery of the Aged Injured Nerve. The 44^th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Glasgow, United Kingdom 11-15 July 2022. Annu Int Conf IEEE Eng Med Biol Soc. In Press
4. Wang Z, Chen S, Smith MF, Jia X. Effect of Graded Targeted Temperature Management on Cerebral Glucose Spatiotemporal Characteristics after Cardiac Arrest. The 44^th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Glasgow, United Kingdom 11-15 July 2022. Annu Int Conf IEEE Eng Med Biol Soc. In Press
5. Du J, Liu X, Yarema KJ, Jia X. Glycoengineering Human Neural Stem Cells (hNSCs) for Adhesion Improvement using a Novel Thiol-Modified N-Acetylmannosamine (ManNAc) Analog. Mater Sci Eng C Mater Biol Appl.
   (Biomaterials Advances) 2022, Volume 134, March 2022, 112675. Epub Jan 21 doi: 10.1016/j.msec.2022.112675.PMID: 35599100 
6. Jiang L, Mee T, Zhou X, Jia X. Augmenting Peripheral Nerve Regeneration with Adipose Derived Stem Cells. Stem Cell Rev Rep.2022 Feb;18(2):544-558. doi: 10.1007/s12015-021-10236-5. Epub 2021 Aug 20. PMID: 34118354
7. Born LJ, McLoughlin ST, Dutta D, Mahadik B, Jia X, Fisher JP, Jay SM. Sustained Released of Bioactive Mesenchymal Stromal Cell-Derived Extracellular Vesicles from 3D-Printed Gelatin Methacrylate Hydrogels. J Biomed Mater Res A. 2022 Jan 25. doi: 10.1002/jbm.a.37362. Online ahead of print. PMID: 35080115
8. Lachance BB, Nielsen N, Jia X*. Are we still withdrawing too soon? – Predictors of late awakening after cardiac arrest. Crit Care Med. 2022 Feb 1;50(2):338-340. doi: 10.1097/CCM.0000000000005379. PMID: 35100197
9. Li J, Ying Y, Su F, Chen L, Yang J, Jia J, Jia X, Xu W. The Hua-shan rehabilitation program after Contralateral Seventh Cervical Nerve Transfer for Spastic Arm Paralysis. Disabil Rehabil.2022 Feb;44(3):404-411. doi: 10.1080/09638288.2020.1768597. Epub 2020 Jun 1. PMID: 32478582
10. Sarkar A, Kim KT, Tsymbalyuk O, Keledjian K, Jia X, Gerzanich V, Simard JM. A direct comparison of physical versus dihydrocapsaicin-induced hypothermia in a rat model of traumatic spinal cord injury. Ther Hypothermia Temp Manag. 2022 Jun;12(2):90-102. doi: 10.1089/ther.2021.0013. Epub 2021 Oct 7. PMID: 35675523
11. Xu X, Zhou X, Du J, Liu X, Qing L, Johnson BN, Jia X*. Macrophage activation in the dorsal root ganglion in rats developing autotomy after peripheral nerve injury. Int J Mol Sci. 2021 Nov 26;22(23):12801. doi: 10.3390/ijms222312801.PMID: 34884605
12. Lachance BB, Wang Z, Badjatia N, Jia X*. The effect of Glibenclamide on somatosensory evoked potentials after cardiac arrest in rats. Neurocrit Care. 2022 Apr;36(2):612-620. doi: 10.1007/s12028-021-01350-w. Epub 2021 Oct 1  PMID: 34599418
13. Zhang S, Lachance BB, Mattson MP, Jia X*. Glucose metabolic crosstalk and regulation in brain function and diseases. Progress in Neurobiology. 2021 Jun 10:102089. doi: 10.1016/j.pneurobio.2021.102089. Online ahead of print. PMID: 34118354
14. Zhou K, Chen H, Xu H, Jia X*. Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy. Oxidative Medicine and Cellular Longevity. 2021 Jul 10;2021:8898996. doi: 10.1155/2021/8898996. eCollection 2021.PMID: 34336117 
15. Zhou X, Du J, Qing L, Mee T, Xu X, Wang Z, Xu C, Jia X*. Identification of Sensory and Motor Nerve Fascicles by Immunofluorescence staining after Peripheral Nerve Injury. J Transl Med. 2021 May 13;19(1):207. doi: 10.1186/s12967-021-02871-w. PMID: 33985539
16. Dumbleton J, Shamul JG, Jiang B, Agarwal P, Huang H, Jia X, He X. Oxidation and RGD modification affect the early neural differentiation of murine embryonic stem cells cultured in core-shell alginate hydrogel microcapsules. Cells Tissues Organs.2021 May 26;1-10. doi: 10.1159/000514580. Online ahead of print. PMID: 34038907
17. Du J, Agatemor C, Saeui CT, Bhattacharya R, Jia X*, Yarema KJ*. Glycoengineering Human Neural and Adipose Stem Cells with Novel Thiol-Modified N-Acetylmannosamine (ManNAc) Analogs. 2021 Feb 12;10(2):377. doi: 10.3390/cells10020377.PMID: 33673061
18. Zhang Y, Xu X, Tong Y, Zhou X, Du J, Choi IY, Yue S, Lee G, Johnson BN, Jia X*. Therapeutic effects of peripherally administrated neural crest stem cells on pain and spinal cord changes after sciatic nerve transection. Stem Cell Res Ther. 2021 Mar 15;12(1):180. doi: 10.1186/s13287-021-02200-4. PMID: 33722287
19. Wang C, Xu T, Zhong X, Lachance BB, Shen G, Xu T, TangC*, Jia X*. Sphk1 regulates neuroinflammation and neuronal injury via S1PR3/p38/NF-κB pathway in SCI. J Neuroinflammation. 2021 Feb 18;18(1):50. doi: 10.1186/s12974-021-02092-4. PMID: 33602274 
20. Chen S, Lachance (Bolduc) B, Gao L, Jia X*. Targeted temperature management and early neuroprognostication post-cardiac arrest. J Cereb Blood Flow Metab 2021 Jan 14;271678X20970059. doi: 10.1177/0271678X20970059.Online ahead of print. PMID: 33444088
21. Wang W^#, Wei H ^#, Shi R, Lin L, Zhang L, Yue S, Zhao Q, Jia X, Li K ^*, Zhang Y ^*. Dysfunctional Muscle Activities and Co-contraction in the Lower-Limb of Lumbar Disc Herniation Patients during Walking. Sci Rep. 2020 Nov 24;10(1):20432. doi: 10.1038/s41598-020-77150-7. PMID: 33235289
22. Wang Z, Du J, Lachance BB, Mascarenhas C, He J, Jia X*. Intracerebroventricular Administration of hNSCs Improves Neurological Recovery after Cardiac Arrest in rats. Stem Cell Rev Rep. 2020 Nov doi: 10.1007/s12015-020-10067-w. Online ahead of print. PMID: 33140234
23. Tsai SY*, Lio CF, Shih SC, Lin CJ, Chen YT, Yu CM, Sun FJ, Kuo CF, Jia X*. The predisposing factors of AKI for prophylactic strategies in burn care. PeerJ 2020 Sep 29;8:e9984. doi: 10.7717/peerj.9984. eCollection 2020. PMID: 33072437
24. Zhang S, Lachance BB, Moiz B, Jia X*. Optimizing Stem Cell Therapy after Ischemic Brain Injury. Journal of Stroke. 2020 Sep;22(3):286-305. doi: 10.5853/jos.2019.03048. Epub 2020 Sep 29. PMID: 33053945
25. Li J, Ying Y, Su F, Chen L, Yang J, Jia J, Jia X, Xu W. The Hua-shan rehabilitation program after Contralateral Seventh Cervical Nerve Transfer for Spastic Arm Paralysis. Disabil Rehabil. 2020 Jun 1:1-8. doi: 10.1080/09638288.2020.1768597. Online ahead of print. PMID: 32478582
26. Du Z, Yin S, X S, Zhang L, Yue S, Jia X, Zhang Y. Identification of Differentially Expressed Genes and Key Pathways in the Dorsal Root Ganglion After Chronic Compression. Front Mol Neurosci2020 May 5;13:71. doi: 10.3389/fnmol.2020.00071. eCollection 2020.
    PMID: 32431596
27. Xu X, Mee T, Jia X*. New Era of Optogenetics: From the Central to Peripheral Nervous System. Crit Rev Biochem Mol Biol. 2020 Feb;55(1):1-16. doi: 10.1080/10409238.2020.1726279. Epub 2020 Feb 18. PMID: 32070147
28. Du Z, Yin S, X S, Zhang L, Yue S, Jia X, Zhang Y. Identification of Differentially Expressed Genes and Key Pathways in the Dorsal Root Ganglion After Chronic Compression. Front Mol Neurosci 2020 May 5;13:71. doi: 10.3389/fnmol.2020.00071. eCollection 2020. PMID: 32431596
29. Ke X^†, Qiu J^†, Yang X, Shen J, Ye S, Yang G, Xu S, Bi Q, Gou Z^*, Jia X^*, Zhang L^*. Modification of Pore-wall in Direct Ink Writing Wollastonite Scaffolds Favorable for Tuning Biodegradation and Mechanical Stability and Enhancing Osteogenic Capability. FASEB J. 2020 Apr;34(4):5673-5687. doi: 10.1096/fj.201903044R. Epub 2020 Mar 1. PMID: 32115776
30. Jiang F, Jones S, Wu Z, Xue J, Jia X*. Microvascular replantation of totally avulsed scalps: failures and successes. J Craniofac Surg. 2020 Mar/Apr;31(2):e185-e189. doi: 10.1097/SCS.0000000000006160. [Epub 2020 Jan 17]  PMID: 31977709
31. Bolduc B, Wang Z, Badjatia N, Jia X*. SSEP in prognostication after cardiac arrest with Targeted temperature management. Neurocritical Care 2020 Jun;32(3):847-857. doi: 10.1007/s12028-019-00903-4. [Epub 2020 Jan 6] PMID: 31907802
32. Wang Z, Mascarenhas C, Jia X*. Positron Emission Tomography after Ischemic Brain Injury: Current Challenges and Future Developments. Translational Stroke Research2020 Aug;11(4):628-642. doi: 10.1007/s12975-019-00765-0. Epub 2020 Jan 14. PMID: 31939060
33. Teng Y^#, Zhang Y^#, Yue S*, Chen H, Qu Y, Wei H, Jia X*. Intrathecal injection of bone marrow stromal cells attenuates neuropathic pain via inhibition of P2X4R in spinal cord microglia. Journal of Neuroinflammation. 2019 Dec 17;16(1):271. doi: 10.1186/s12974-019-1631-0. PMID: 31847848
34. Du J, Jia X*. Engineering nerve guidance conduits with 3D bioprinting technology for long gap peripheral nerve regeneration. Neural Regen Res. 2019, 14(12):2073-2074. doi:10.4103/1673-5374.262580 PMID: 31397337
35. Yang X, Wang Z, Jia X. Neuroprotection of Glibenclamide against Brain Injury after Cardiac Arrest via Modulation of NLRP3 Inflammasome. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:4209-4212. doi: 10.1109/EMBC.2019.8857285. PMID: 31946797
36. Wang Z, Yang X, He J, Du J, Liu S, Jia X. Intracerebroventricular Administration of Neural Stem Cells after Cardiac Arrest. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:4213-4216. doi: 10.1109/EMBC.2019.8857270. PMID: 31946798
37. Zhou X, Du J, Jia X. Effects of Hydrogel-Fiber on Cystic Cavity after Spinal Cord Injury. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:1070-1073. doi: 10.1109/EMBC.2019.8857115. PMID: 31946079
38. He J, Lu H, Young L, Deng R, Callow D, Tong S, Jia X*. Real-time quantitative monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest with targeted temperature management. J Cereb Blood Flow Metab. 2019 Jun;39(6):1161-1171. doi: 10.1177/0271678X17748787. Epub 2017 Dec 28. PMID: 29283290
39. Zhen G, Chen H, Tsai SY, Zhang J, Chen T, Jia X*. Long-term Feasibility and Biocompatibility of Directly Microsurgically Implanted Intrafascicular Electrodes in Free Roaming Rabbits. J Biomed Mater Res B Appl Biomater. 2019 Feb;107(2):435-444. doi: 10.1002/jbm.b.34135. Epub 2018 Apr 19. PMID: 29675920
40. Wang G, Qiu Y, Yu A, Jiang S, Jia J, Jia X, Xu W. Simple Grading for Motor Function in Spastic Arm Paralysis: Hua-Shan Grading of Upper Extremity. Journal of Stroke and Cerebrovascular Diseases. 2019 Aug;28(8):2140-2147. doi: 10.1016/j.jstrokecerebrovasdis.2019.04.006. Epub 2019 May 22. PMID: 31129103
41. Zhang L, Yang G, Johnson BN, Jia X*. Three-dimensional (3D) Printed Scaffolds and Materials Selection for Bone Repair. Acta Biomater. 2019 Jan 15;84:16-33. doi: 10.1016/j.actbio.2018.11.039. Epub 2018 Nov 24. PMID: 30481607
42. Jia X*, Peng Z. Translational Critical Care Medicine: Integrating State‑of‑the‑Art Knowledge between Bench and Bedside. Journal of Translational Critical Care Medicine. 2019 Jan; 1(1): 2-3
43. Qing L, Chen H, Tang J, Jia X*. Exosomes and their microRNA cargo: new players in peripheral nerve regeneration. Neurorehabilitation & Neural Repair.2018 Sep;32(9):765-776. doi: 10.1177/1545968318798955. PMID: 30223738
44. Yang X, Sun J, Kim TJ, Kim YJ, Ko SB, Jia X*, Yoon BW*. Pretreatment with Low-dose Fimasartan Ameliorates NLRP3 Inflammasome-Mediated Neuroinflammation and Brain Injury after Intracerebral Hemorrhage. Exp Neurol. 2018 Aug 29. pii: S0014-4886(18)30405-9. doi: 10.1016/j.expneurol.2018.08.013. [Epub ahead of print] PMID: 30171865
45. Du J, Zhen G, Chen H, Zhang S, Qing L, Yang X, Lee G, Mao HQ, Jia X*. Optimal Electrical Stimulation Boosts Stem Cell Therapy in Nerve Regeneration. Biomaterials. 2018 Oct;181:347-359. doi: 10.1016/j.biomaterials.2018.07.015. Epub 2018 Jul 20. PMID: 30098570
46. Wang Q^#, Zhang H^#, Xu H^#, Zhao Y, Li Z, Li J, Wang H, Zhuge D, Guo X, Xu H, Jones S, Li X, Jia X*, Xiao J *.Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair. Theranostics 2018; Aug 7;8(16):4429-4446. doi: 10.7150/thno.26717. eCollection 2018. PMID: 30214630
47. Du J, Chen H, Qing L, Yang X, Jia X*. Biomimetic Neural Scaffolds: A Crucial Step Towards Optimal Peripheral Nerve Regeneration. Biomater Sci.2018 May 29;6(6):1299-1311. doi: 10.1039/c8bm00260f. Epub 2018 May 4 PMID: 29725688
48. Li R^#, Li Y^#, Wu Y, Zhao Y, Chen H, Yuan Y, Xu K, Zhang H, Lu Y, Wang J, Li X, Jia X*, Xiao J*.Heparin-Poloxamer Thermosensitive Hydrogel Loaded with bFGF and NGF Enhances Peripheral Nerve Regeneration in Diabetic Rats. Biomaterials. 2018 Jun;168:24-37. doi: 10.1016/j.biomaterials.2018.03.044. Epub 2018 Mar 26PMID: 29609091
49. Simard JM^*, Jia X*and Gerzanich V. Pharmacological Induced Target Temperature Management after Cardiac arrest: the capsaicinoids. Neural Regen Res. 2017 12(10):1623-1624PMID: 29171426
50. Du J, Chen H, Zhou K, Jia X*. Quantitative Multimodal Evaluation of Passaging Human Neural Crest Stem Cells for Peripheral Nerve Regeneration. Stem Cell Reviews and Reports.2017 Aug 5. doi: 10.1007/s12015-017-9758-9. [Epub ahead of print] PMID: 28780695
51. Tsai SY, Chen HJ, Lio CF, Ho HP, Kuo CF, Jia X, Chen C, Chen YT, Chou YT, Yang TY, Sun FJ, Shi L. Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study. PLoS One. 2017 Aug 22;12(8):e0179447. doi: 10.1371/journal.pone.0179447. eCollection PMID: 28829784
52. HeZ^#,Zhou S^#,YinJ, Gao Z, Liu Y, Wu Y, HeH, ZhouY, WangQ, LiJ, WuF, XuHZ,Jia X*, XiaoJ*. Inhibition of Endoplasmic Reticulum Stress Preserves the Integrity of Blood-Spinal Cord Barrier in Diabetic Rats Subjected to Spinal Cord Injury. Scientific Reports. 2017 Aug 9;7(1):7661. doi: 10.1038/s41598-017-08052-4. PMID: 28794417
53. Choudhary RC, Jia X*. Hypothalamic or Extra-hypothalamic Modulation and Target Temperature Management after Brain Injury. Therapeutic Hypothermia and Temperature Management2017Sep;7(3):125-133. doi: 10.1089/ther.2017.0003. Epub 2017 May 3. PMID: 28467285
54. ChenH, DuJ, ZhangY, BarnesK, Jia X*. Establishing a Reliable Gait Evaluation Method for Rodent Studies. Journal of Neuroscience Methods2017 May 1;283:92-100. doi: 10.1016/j.jneumeth.2017.03.017. Epub 2017 Mar 27.  PMID: 28351803
55. Zhou K, Sansur CA, Xu H, Jia X*. The temporal pattern, flux, and functionof autophagy in spinal cord injury.Int J Mol Sci.2017Feb 21;18(2). pii: E466. doi: 10.3390/ijms18020466. PMID: 28230791
56. WangX, Chaudhry SA, Hou W, Jia X*. Developing and Evaluating a Flexible Wireless microcoil array based Integrated Interface for Epidural Cortical Stimulation.Int J Mol Sci.2017 Feb 5;18(2). pii: E335. doi: 10.3390/ijms18020335. PMID:28165427
57. JiangL, JonesS, Jia X*. Stem cell transplantation for peripheral nerve regeneration: Current options and opportunities. Int J Mol Sci.2017 Jan 5;18(1). pii: E94. doi: 10.3390/ijms18010094. PMID: 28067783
58. Jones S, Schwartzbauer G, Jia X*. Brain Monitoring in Critically Neurologically Impaired Patients. Int J Mol Sci. 2016 Dec 27;18(1). pii: E43. doi: 10.3390/ijms18010043 PMID: 28035993
59. Jia X*. Translational Medicine: Creating the Crucial Bidirectional Bridge between Bench and Bedside. Int. J. Mol. Sci. 2016, Nov 16;17(11). pii: E1918; doi: 10.3390/ijms17111918 PMID: 27854337
60. Johnson BN and Jia X*. 3D Printed Nerve Guidance Channels: Computer-aided Control of Geometry, Physical Cues, Biological Supplements and Gradients. Neural Regen Res. 2016 Oct;11(10):1568-1569. PMID: 27904481
61. Jones S, Eisenberg HM, Jia X*. Advances and future application of augmented peripheral nerve regeneration. Int J Mol Sci. 2016 Sep 7;17(9). pii: E1494; doi:10.3390/ijms17091494 PMID: 27618010
62. Cui D, Shang H, Young L, Zhang X, Jiang W, Jia X*. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific Reports. 2016 6:27642 DOI: 10.1038/srep27642 PMID: 27273382
63. Choi YS*, Jia X*. Information-theoretical Quantifier of Brain Rhythm Based on Data-driven Multiscale Representation. Biomed Research International. 2015;2015:946201. Epub 2015 Nov 12. PMID: 26640802
64. Deng R,  Xiong W, Jia X*. Electrophysiological Monitoring of Brain Injury and Recovery after Cardiac Arrest. Int J Mol Sci. 2015 Oct 30;16(11):25999-6018. doi: 10.3390/ijms161125938 PMID: 26528970
65. Johnson BN, Lancaster KZ, Zhen G, He J, Gupta MK, Kong YL, Engel EA, Krick KD, Ju A, Meng F, Enquist LW, Jia X*, McAlpine MC*. 3D Printed Nerve Regeneration Pathways. Advanced Functional Materials  2015 October 21; 25 (39): 6205–6217. [Epub 2015 SEP 18], PMID: 26924958 (* indicate Co-corresponding authors) Highlighted in NIH Research Matters and NIH 2015 Research Highlights
66. Karapetkova M, Koenig MA, Jia X*. Early Prognostication Markers in Cardiac Arrest Patients Treated with Hypothermia. European Journal of Neurology. 2016 Mar;23(3):476-88. doi: 10.1111/ene.12803. Epub 2015 Jul 31. PMID: 26228521
67. Deng R, Koenig MA, Young LM, Jia X*. Early Quantitative Gamma-Band EEG Marker is Associated with Outcomes after Cardiac Arrest and Targeted Temperature Management. Neurocritical Care. 2015 Oct;23(2):262-73. doi: 10.1007/s12028-015-0157-2. [Epub 2015 Jul 1]  PMID: 26130405
68. Jia X *, Romero-Ortega MI, Teng YD. Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies. BioMed Research International. 2014;2014:145304. doi: 10.1155/2014/145304. Epub 2014 Dec 23 PMID: 25587530
69. Xiong W, Jia X*.Is Neurologic Prognostication After Hypothermia Ready for Primetime? Critical Care Medicine. 2014, Dec;42(12):2644-2645. PMID: 25402291
70. Hutton DL, Kondragunta R, Moore EM, Hung BP, Jia X, Grayson WL. Tumor Necrosis Factor Improves Vascularization in Osteogenic Grafts Engineered with Human Adipose-Derived Stem/Stromal Cells. PLoS One. 2014 Sep 23;9(9):e107199. doi: 10.1371/journal.pone.0107199. eCollection 2014. PMID: 25248109
71. Temple JP, Hutton DL, Hung BP, Huri PY, Cook CA, R Kondragunta, Jia X, Grayson WL. Engineering Anatomically Shaped Vascularized Bone Grafts with hASCs and 3D-Printed PCL Scaffolds. J Biomed Mater Res A. 2014 Dec;102(12):4317-25. doi: 10.1002/jbm.a.35107. Epub 2014 Feb 19 PMID: 24510413
72. Chen C, Maybhate A, Israel D, Thakor NV, Jia X*. Analysis of Granger Causality for Assessment of Thalamocortical Functional Connectivity. IEEE Trans Neural Syst Rehabil Eng.2013 Sep;21(5):725-33. doi: 10.1109/TNSRE.2013.2271246. Epub 2013 Jul 10 PMID: 23864221
73. Li J, Zhen G, Tsai SY, Jia X*. Epidermal Stem Cells in Orthopaedic Regenerative Medicine. International Journal of Molecular Sciences. 2013 May 31;14(6):11626-42. doi: 10.3390/ijms140611626 PMID: 23727934
74. Zhen G, Wen C, Jia X, Li Y, Crane JL, Mears SC, Askin FB, Frassica FJ, Chang W, Yao J, Carrino JA, Cosgarea A, Artemov D, Chen Q, Zhao Z, Zhou X, Riley L, Sponseller P, Wan M, Lu WW, Cao X. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nature Medicine 2013 Jun;19(6):704-12. doi: 10.1038/nm.3143. Epub 2013 May 19. PMID: 23685840 Highlighted in [Editorials] by Bush JR, Beier F. TGF-β and osteoarthritis--the good and the bad. Nat Med. 2013 Jun;19(6):667-9. doi: 10.1038/nm.3228, and in Nat Rev Rheumatol by Leah E. Osteoarthritis: TGF-β overload at bones of cartilage degeneration. 2013 Jul;9(7):382. doi: 10.1038/nrrheum.2013.81. Epub 2013 May 28.
75. Nag S, Jia X, Thakor NV, Sharma D. Flexible Charge Balanced Stimulator with 5.6 fC Accuracy for 140 nC Injections. IEEE Transactions on Biomedical Circuits and Systems 2013; 7(3): 266-275 DOI:10.1109/TBCAS.2012.2205574 PMID: 23853326
76. Liu S, Jia X, Li C, Han X, Yan W, Xing Y. CXCR7 silencing attenuates cell adaptive response to stromal cell derived factor 1α after hypoxia. PLOS ONE 2013;8(1):e55290. doi: 10.1371/journal.pone.0055290. Epub 2013 Jan 31 PMID: 23383139
77. Jia X*, Kowalski RG, Sciubba DM, Geocadin RG. Critical Care of Traumatic Spinal Cord Injury. J Intensive Care Med. 2013 Jan-Feb;28(1):12-23. doi: 10.1177/0885066611403270. Epub 2011 Apr 11. PMID: 21482574
78. Wan M, Li C, Zhen G, Jiao K, He W, Jia X, Wang W, Shi C, Xing Q, Chen YF, Jan De Beur S, Yu B, Cao X. Injury-Activated TGFβ Controls Mobilization of Mscs for Tissue Remodeling. Stem Cells 2012 Nov;30(11):2498-511. doi: 10.1002/stem.1208. Epub 2012 Aug 21 PMID: 22911900
79. Kortelainen J, Jia X, Seppänen T, Thakor NV. Increased electroencephalographic gamma activity reveals awakening from isoflurane anaesthesia in rats. British Journal of Anaesthesia. 2012 Nov;109(5):782-9 doi: 10.1093/bja/aes265. Epub 2012 Aug 19 PMID: 22907339
80. Tan EW, Ting BL, Jia X, Skolasky RL, McFarland EG. Diagnostic errors in orthopaedic surgery: evaluation of resident documentation of neurovascular examinations for orthopaedic trauma patients. Am J Med Qual 2013 Jan;28(1):60-8. doi: 10.1177/1062860612447856. Epub 2012 Jul 13. PMID: 22798636
81. Xian L, Wu X, Pang L, Lou M, Rosen C, Qiu T, Crane J, Frassica F, Zhang L, Rodriguez JP, Jia X, Yakar S, Xuan S, Efstratiadis A, Wan M, Cao X. Matrix IGF-1 Regulates Bone Mass by Activation of mTOR in Mesenchymal Stem Cells. Nature Medicine 2012 18 (7), 1095-1101 Epub 2012 Jun 24. doi: 10.1038/nm.2793. PMID: 22729283 Highlighted in Nat Rev Rheumatol by Carney EF.Bone: modulation of IGF-1 might prevent osteoporosis. 2012 Aug;8(8):440. doi: 10.1038/nrrheum.2012.112. Epub 2012 Jul 10
82. Zhang D, Jia X, Ding H. The effect of anesthetic concentration on burst-suppression of the EEG in rats. Journal of Biomedical Engineering (Sheng Wu Yi Xue Gong Cheng Xue Za Zhi). 2012 Apr;29(2):223-8, 232. PMID: 22616162
83. Madhok J, Wu D, Xiong W, Geocadin RG, Jia X*. Hypothermia amplifies somatosensory evoked potentials in uninjured rats. J Neurosurg Anesthesiol. 2012 Jul;24(3):197-202 Equb 2012 Mar 20 PMID: 22441433
84. Wu D, Xiong W, Jia X, Geocadin RG, Thakor NV. Short- and Long-latency Somatosensory Neuronal Responses Reveal Selective Brain Injury and Effect of Hypothermia in Global Hypoxic-Ischemia. Journal of Neurophysiology 2012 Feb;107(4):1164-71. Epub 2011 Dec 7 PMID: 22157111
85. Dewan AK, Garzon-Muvdi J, Petersen SA, Jia X, McFarland EG. Intraarticular Abnormalities in Overhead Athletes Are Variable. Clin Orthop Relat Res 2012 Jun;470(6):1552-7 Epub 2011 Nov 18 PMID: 22095131
86. Ma Y, Hu Y, Valentin N, Geocadin R, Thakor NV, Jia X*. Time Jitter of Somatosensory Evoked Potentials in Recovery from Hypoxic-ischemic Brain Injury. Journal of Neuroscience Methods 2011 Oct 15;201(2):355-360. Epub 2011 Aug 22. PMID: 21878352
87. Jia X*, Peters PG, Schon L. The Use of Platelet-Rich Plasma in the Management of Foot and Ankle Conditions. Operative Techniques in Sports Medicine 2011 Sept 19(3) 177-184 DOI
88. Jia X, Yokota A, McCarty EC, Nicholson GP, Weber SC, McMahon PJ, Dunn WR, McFarland EG. Reproducibility and Reliability of the Snyder Classification of Superior Labral Anterior Posterior Lesions Among Shoulder Surgeons. Am J Sports Med 2011 May;39(5):986-91. Epub 2011 Feb 1 PMID: 21285446
89. Lewitus D, Vogelstein J, Zhen G, Choi YS, Kohn J, Harshbarger S, Jia X*. Designing Tyrosine-derived Polycarbonate Polymers for Biodegradable Regenerative Type Neural Interface Capable of Neural Recording. IEEE Trans Neural Syst Rehabil Eng. 2011 Apr;19(2):204-12. Epub 2010 Dec 10. PMID: 21147598
90. Wu D, Anastassios B, Xiong W, Madhok J, Jia X, Thakor NV. Study of the origins of short- and long-latency SSEP during recovery from brain ischemia in a rat model. Neuroscience Letters 2010 Nov 26;485(3):157-61. Epub 2010 Sep 21 PMID: 20816917
91. Jia X, Ji JH, Pannirselyam VK, Petersen S, McFarland EG. Does a Positive Neer Impingement Sign Reflect Rotator Cuff Contact with the Acromion? Clin Orthop Relat Res, 2011 Mar;469(3):813-8. Epub 2010 Sep 28 PMID: 20878281
92. Madhok J, Maybhate A, Xiong W, Geocadin RG, Jia X*, Thakor NV*. Quantitative Assessment of Somatosensory Evoked Potentials after Cardiac Arrest in Rats: Prognostication of Functional Outcomes. Critical Care Medicine 2010 Aug;38(8):1709-17. Epub 2010 Jun 3 PMID: 20526197 Highlighted in [Editorials] by Young GB. Promising prognostic potentials: perhaps. Crit Care Med. 2010 Aug;38(8):1753. doi: 10.1097/CCM.0b013e3181e8788c (* indicate Co-corresponding authors)
93. Choi Y, Koenig MA, Jia X, Thakor NV. Quantifying Time-varying Multiunit Neural Activity using Entropy based Measures. IEEE Tran. Biomedical Eng 2010 Nov 57(11):2771-7. May 10. [Epub ahead of print] PMID: 20460201
94. Xiong W, Koenig M, Madhok J, Jia X, Puttgen HA, Thakor NV, Geocadin RG. Evolution of Somatosensory Evoked Potentials after Cardiac Arrest Induced Hypoxic-Ischemic Injury. Resuscitation 2010 Jul;81(7):893-7. Epub 2010 Apr 24. PMID: 20418008 Highlighted in [Editorials] by Young GB. Somatosensory evoked potentials after cardiac arrest: a stimulus for investigation. Resuscitation. 2010 Jul;81(7):784-5. doi: 10.1016/j.resuscitation.2010.03.032. Epub 2010 Apr 24.
95. McFarland EG, Garzon-Muvdi J, Jia X, Desai P, Petersen SA. Clinical and Diagnostic Tests for Shoulder Disorders: A Critical Review. British Journal of Sports Medicine 2010;44(5):328-3320 Epub 2009 Dec 2. PMID: 19955165
96. Jia X, Petersen S, Khosravi AH, Almareddi V, Pannirselvam V, McFarland EG. Examination of the Shoulder: the Past, the Present, and the Future. The Journal of Bone and Joint Surgery (AM)  2009 91(Suppl 6):10-18 PMID: 19884407
97. McFarland EG, Tanaka MJ, Garzon-Muvdi J, Jia X, Petersen S. Clinical and imaging assessment for superior labrum anterior and posterior lesions. Curr Sports Med Rep. 2009 Sep-Oct;8(5):234-9 PMID: 19741350
98. Jia X, Ji JH, Petersen S, Freehill MT, McFarland EG. An Analysis of Shoulder Laxity in Patients Undergoing Shoulder Surgery. The Journal of Bone and Joint Surgery (AM) 2009 Sep;91(9):2144-50 PMID: 19723991
99. Zhang D, Jia X, Ding H, Ye D, and Thakor NV. Application of Tsallis Entropy to EEG: Quantifying the Presence of Burst Suppression after Asphyxial Cardiac Arrest in Rats. IEEE Tran. Biomedical Eng 2010 57 (4): 867 – 874 Epub 2009 Aug 18. PMID: 19695982
100. Kang X, Jia X, Geocadin RG, Thakor NV, Maybhate A. Multi-scale entropy analysis for assessment of post-cardiac arrest recovery under hypothermia. IEEE Tran. Biomedical Eng 2009 April 50 (4):1023-31 PMID: 19174339
101. Koenig MA, Jia X, Kang X, Velasquez A, Thakor NV, Geocadin RG. Intraventrcular Orexin-A Improves Arousal and EEG Entropy in Rats after Cardiac Arrest. Brain Res. 2009 Feb 19;1255:153-61. Epub 2008 Dec 16.   PMID: 19111527
102. Li N, Jia X, Murari K, Parlapalli R, Rege A, Thakor NV. High Spatiotemporal Resolution Imaging of the Neurovascular Response to Electrical Peripheral Trigeminal Nerve Stimulation as Revealed by in vivo Laser Speckle Contrast. Journal of Neuroscience Methods 2009 Jan;176(2):230-6. Epub 2008 Jul 25. PMID: 18706442
103. Jia X, Ji JH, Petersen S, Keefer J, McFarland EG. Clinical Evaluation of the Shoulder Shrug Sign. Clin Orthop Relat Res,  2008 Nov;466(11):2813-9 PMID: 18543050
104. Jia X*, Koenig MA, Venkatraman A, Thakor NV, Geocadin RG. Post-cardiac arrest temperature manipulation alters early EEG bursting in rats. Resuscitation 2008 Sep; 78, (3):367-373 PMID: 18597914
105. Shin HC, Jia X, Nickl R, Geocadin RG and Thakor NV. A Subband-based Information Measure of EEG During Brain Injury and Recovery After Cardiac Arrest, IEEE Tran. Biomedical Eng 2008 Aug;55(8):1985-90PMID: 18632361 Highlighted in Journal Cover Illustration
106. Geocadin RG, Koenig MA, Jia X, Stevens RD, Peberdy MA. Management of brain injury after resuscitation from cardiac arrest. Neurol Clin 2008 May 26 (2) 487-506 PMID: 18514823
107. Jia X*, Koenig MA, Nickl R, Zhen G, Thakor NV, Geocadin RG. Early Electrophysiologic Markers Predict Functional Outcome Associated with Temperature Manipulation after Cardiac Arrest in Rats. Critical Care Medicine 2008; 36 (6):1909-16 PMID: 18496359 Highlighted in [Editorials] by Tempelhoff, René MD; Yoder, Jeffrey MD. Monitoring the brain: Lack of tools or lack of will? Critical Care Medicine 2008; 36 (6):1983-1984
108. Jia X*, Zhen G, Puttgen A, Zhang J, Chen T. Improved long-term recording of nerve signal by modified intrafascicular electrodes in rabbits. Microsurgery 2008 28(3): 173-178 PMID: 18286654
109. McFarland EG, Srikumaran U, Petersen SA, Jia X and Fayad LM. How to make sense of shoulder MRI: determining when to treat and when to refer. J Musculoskelet Med 2007 24(12):500-506
110. Jia X*, Koenig MA, Shin HC, Zhen G, Pardo CA, Hanley DF, Thakor NV, Geocadin RG. Improving neurological outcomes post-cardiac arrest in a rat model: Immediate hypothermia and quantitative EEG monitoring. Resuscitation, 2008 March 76(3), 431-442 PMID: 17936492
111. Murari K, Li N, Rege A, Jia X, All A, Thakor NV. Contrast Enhanced Imaging of Cerebral Vasculature with Laser Speckle. Applied Optics. 2007 Aug 1, 46(22), 5340-5346 PMID: 17676149
112. Jia X*, Koenig MA, Zhang X, Zhang J, Chen T, Chen Z. Residual Motor Signal In Long-Term Human Severed Peripheral Nerves And Feasibility Of Neural Signal-Controlled Artificial Limb. The Journal of Hand Surgery (AM). 2007 May-June, 32(5), 657-666 PMID: 17482005
113. Jia X*, Koenig MA, Shin HC, Zhen G, Yamashita S, Thakor NV, Geocadin RG. Quantitative EEG and Neurological Recovery after therapeutic Hypothermia of Asphyxial Cardiac Arrest in Rats. Brain Research, 2006 September 21, 1111(1) 166-175 PMID: 16919609
114. Shin HC, Tong S, Yamashita S, Jia X, Geocadin RG, Thakor NV, Quantitative EEG and Effect of Hypothermia on Brain Recovery After Cardiac Arrest. IEEE Trans. on Biomedical Eng, 2006 Jun, 53 (6): 1016-1023 PMID: 16761828
115. Hu T, Zhang X, Zhang Z, Zhang J, Jia X, Zheng X, Yang Y, Chen Z, Xu X, Chen T. Initial detection and analysis of neuro-information from amputee. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2006 Feb; 23(1):1-5 PMID: 16532797

Dr. Jia's research interests include brain monitoring and therapeutic hypothermia, brain recovery after cardiac arrest, peripheral nerve injury and regeneration, the translational therapeutic model for neurological injuries, and the development and characterization of biomaterials for peripheral nerve and bone regeneration.

1. Brain Recovery after Cardiac Arrest 

This project will develop and optimize a novel glycan-based intervention via metabolic glycoengineering to promote neural stem cell interaction in vitro, and to improve neurological outcomes after cardiac arrest. It will track the fate of transplanted neural stem cells and explore related mechanisms with improved cell survival. We also focus on the development of novel translational tools for uncovering mechanisms of brain injury after cardiac arrest, monitoring and tracking neurological injuries, and guiding treatments like therapeutic hypothermia.

2. Peripheral Nerve Injury and regeneration

This project will enhance adipose stem cell adhesion and differentiation in vitro via stem cell surface modification, and improve nerve regeneration after critical-sized nerve repair with sugar analog treated adipose stem cells. Our lab will also investigate the effect of NCSC derived exosome therapy in peripheral nerve crush injury and nerve defect repair animal models.

3. Spinal cord injury

We aim to explore pathological mechanisms of spinal cord injury, monitor and track neurological injuries, and develop novel therapeutic methods to promote neuroregeneration and neuroprotection.

• Society of Critical Care Medicine Star Research Achievement Award, 2022
• Society of Critical Care Medicine Presidential Citation Award, 2022
• Society of Critical Care Medicine Star Research Achievement Award, 2021
• Society of Critical Care Medicine Neuroscience Section Congress Scholarship, 2021
• Society of Critical Care Medicine Anesthesiology Section Congress Scholarship, 2021
• Society of Critical Care Medicine Bronze Snapshot Awards, 2020
• Highlight in NIH Research Matters and NIH Research Highlights, 2015
• Best Abstract Presentations, 5th International Hypothermia Symposium, 2014
• Finalist of Student Paper Competition Award at the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC), 2013 (as sponsor Faculty and corresponding author)
• Highlight as a significant advance based on animal research at the 65th American Academy of Neurology (AAN) Annual Meeting, 2013
• Best Presentation Winner for Clinicians in the 2nd Annual Safer Symposium in Johns Hopkins Bayview Medical Center, 2010
• Top 20 Scientific Exhibits Award of the American Academy of Orthopaedic Surgeons (AAOS), 2009
• Finalist of the Best Overall Poster Award of American Academy of Orthopaedic Surgeons (AAOS), 2008
• Recipient of Annual Research Award of American Association for Hand Surgery (AAHS) (Three awarded nationally), 2008
• Finalist of Research Citation Award of the Society of Critical Care Medicine, 2008
• American Heart Association (AHA) CPCC Junior Investigator travel award, 2007
• Selected Presentation for the Press Book of The 36th Annual Meeting of the Society for Neuroscience, 2006

NIH/NINDS 5 RO1
X Jia (PI)
08/1/2022 - 7/31/2027
Improving Brain Recovery Through Glycoengineering  

NIH/NINDS 5 RO1
X Jia (PI)
01/15/2021 - 12/31/2025
Stem Cell Surface Modification to Promote Nerve Regeneration Recovery 

Maryland Stem Cell Research Fund (MSCRF) Discovery Program
X Jia (PI)
7/01/20 - 6/30/22 NCE 6/30/23
Developing Human iPSC-Derived Exosome Therapy to Improve Recovery after Peripheral Nerve Injury

NIH/NINDS 5 RO1
X Jia (PI)
9/30/2018 - 6/30/2023
Brain Recovery after Cardiac Arrest with Metabolic Glycoengineered Stem Cells

Completed

Maryland Stem Cell Research Fund (MSCRF) Discovery Program
X Jia (PI)
7/01/18 - 6/30/20 NCE 6/30/2021
Novel 3D bioprinted scaffolds to promote neural crest cell-mediated nerve regeneration

Institute for Clinical & Translational Research Award 
X Jia (PI)
12/23/19 - 6/21/21
Impact of temperature on brain glucose metabolism after cardiac arrest with hypothermia

NIH/NHLBI 5 RO1
X Jia (PI)
7/1/2013 - 11/30/2018 NCE 11/30/2020
Brain Monitoring and Therapeutic Hypothermia after Cardiac Arrest

Maryland Stem Cell Research Fund (MSCRF)
X Jia (Subaward PI)
7/1/2014 – 6/30/2017
PDGF-Modified Fibrin Hydrogels for ASC-Mediated Bone Repair

Maryland Stem Cell Research Fund (MSCRF)
X Jia (PI)
7/01/13 - 6/30/15 NCE 6/30/16
Electrical Stimulation on Neural Crest Stem Cell Transplantation in Nerve Regeneration

American Heart Association
09SDG2110140
X Jia (PI)
7/1/2009-6/30/2013 NCE 6/30/2014
Quantitative Somatosensory Evoked Potential: Novel approach to Monitoring Neurologic Recovery Post Cardiac Arrest

Jan 2021: Dr. Jia was elected as the Chair, Research Section, Member of the Discovery Steering Committee, Member of the Discovery Oversight Committee, the Society of Critical Care Medicine (SCCM).

Feb 2020: Dr. Jia was elected as the Chair-elect, Research Section, Member of the Discovery Steering Committee, Member of the Discovery Oversight Committee, the Society of Critical Care Medicine (SCCM).

Dr. Jia was elected as a fellow of the American College of Critical Care Medicine (FCCM) from 2019.

Feb 2019: Dr. Jia has been elected into the Society of Critical Care Medicine (SCCM) Research Section Board as a Secretary/Treasurer after being a member at large for three years. SCCM is a quite large multidiscipline community with 16,000 members in more than 100 countries. This will be a 1-year appointment, with a transition to chair-elect for one year, chair for one year, and immediate past chair for one year.

Journal Editor:

Editor-in-Chief, International Journal of Molecular Sciences (2021 Impact Factor – 6.208), section "Molecular Pathology, Diagnostics, and Therapeutics"

Co-Executive Editor-in-Chief, Journal of Translational Critical Care Medicine

Associate Editor, Multiple Sclerosis and Neuroimmunology Section, Frontiers in Immunology (2021 Impact factor 8.786)

Associate Editor, Translational Neuroscience section, Frontiers in Neuroscience (2021 Impact factor 5.152)

Associate Editor, Multiple Sclerosis and Neuroimmunology, Frontiers in Neurology (2021 Impact factor 4.086)

Guest Editor:

Frontiers in Cell and Developmental Biology -- Cell Death and Survival (2020 Impact factor 6.684)

Special Issue: Programmed Cell Death and Central Nervous System (CNS) Trauma, 2021-present

Frontiers in Immunology -- Multiple Sclerosis and Neuroimmunology (2021 Impact factor 8.786)

Special Issue: Neuro-Immune Interactions and Neuroinflammation in Neurocritical Care, 2021-present

Frontiers in Bioengineering and Biotechnology --Biomaterials (2021 Impact factor 6.064)

Special Issue: 3D-printed Biomaterials in Osteochondral Repair, 2021-present

Frontiers in Cell and Developmental Biology -- Cell Growth and Division (2020 Impact factor 6.684)

Special Issue: The Interplay Between the Skeletal and Nervous System During Development and Aging, 2021-present

Frontiers in Bioengineering and Biotechnology – Biomaterials (2021 Impact factor 6.064)

Special Issue: Functionally-adapted Biomaterials for Diagnosis, Treatment and Prevention. 2022-present

International Journal of Molecular Sciences:

Special Issue: Neurological Injuries’ Monitoring, Tracking, and Treatment, 2013-2016

Special Issue: Neurological Injuries’ Monitoring, Tracking, and Treatment, 2016-present

Special Issue: Peripheral Nerve Regeneration: From Bench to Bedside, 2016-present

BioMed Research International: Lead Guest Editor: 

Special Issue on Peripheral Nerve Regeneration: Mechanism, Cell Biology, and Therapies, 2013-2014

Editorial Board:

Scientific Reports

International Journal of Molecular Sciences

Behavioural Neurology

Selected Invited Conference Abstract Grader and Reviewer

5th International Neural Regeneration Symposium (INRS2016) and the 10th Asia Pacific Symposium on Neural Regeneration (APSNR2016)

The 4-5th International Conference of Rehabilitation Medicine and Engineering, 2015

The 2015 Biomedical Engineering Society (BMES) Annual Meeting, Orthopaedic and Rehabilitation Engineering track, 2015

The 6-7^th International IEEE Engineering in Medicine and Biology Society (EMBS) Conference on Neural Engineering, 2013-2015

The 38^th - 45^th Society of Critical Care Medicine annual Congress, 2008-2016

Selected Invited Conference Moderator:

Section Chair, 2021 Congress of The International Society of Physical and Rehabilitation Medicine (ISPRM), 06/2021            

Moderator, The 50th Critical Care Congress,  Virtual Event, January 31 - February 12, 2021, USA

Co Section Chair, 41st International Engineering in Medicine and Biology Conference (EMBC 2019). Berlin, Germany • 23-27 July 2019.

Judge, 3rd Annual Conference of Chinese Stroke Association (CSA) & Tiantan International Stroke Conference 2017 (TISC 2017), Beijing, China

International program committee, The 8^th International IEEE Engineering in Medicine and Biology Society (EMBS) Conference on Neural Engineering, 2017

Judge, 2016 Zhu Jia-kai best case report on microsurgery, Sun Yat-sen Medicine Forum 2016, Sept 23-25, Guangzhou, China

5th International Neural Regeneration Symposium (INRS2016) and the 10th Asia Pacific Symposium on Neural Regeneration (APSNR2016)

International Committee Co-Chair, Section Chair, Moderator, The 3rd-5th International Conference of Rehabilitation Medicine and Engineering, 2014-2016

Professor Walk Round Moderator in the 39^th - 44^th Society of Critical Care Medicine Annual Congress, 2009-2015

Johns Hopkins University 14th Annual ACCM Research Day, 2013