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Rebecca J. Henry, PhD

Academic Title:

Research Associate

Primary Appointment:

Anesthesiology

Location:

STAR Research Laboratories, Department of Anesthesiology, University of Maryland School of Medicine, 655 West Baltimore Street, Room #6-017, Baltimore, MD 21201

Phone (Primary):

410-706-2984

Fax:

410-706-1639

Education and Training

2007-2011: Bachelor of Science (B.Sc Hons), Physiology, National University of Ireland, Galway (NUIG), Ireland

2011-2015: Graduate Student in the Department of Physiology, NUIG, Ireland

2015-2019: Postdoctoral Reserach Fellow in Star Center, University of Maryland School of Medicine 

Highlighted Publications

 

Peer-reviewed journal articles 

  1. Henry RJ, Doran S, Barrett JP, Meadows VE, Sabirzhanov B, Stoica BA, Loane DL, Faden Inhibition of miR-155 limits neuroinflammation and improves functional recovery after experimental traumatic brain injury in mice. Neurotherapeutics. 16(1):216-230, 2019. PMID 30225790.
  2. Kumar A, Henry RJ, Stoica B, Loane D, Abulwerdi G, Bhat S, Faden A. Neutral Sphingomyelinase Inhibition Alleviates LPS Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury. J Pharmacol Exp Ther 368(3):338-352, 2019/ PMID 30563941.
  3. Doran SJ, Ritzel RM, Glaser EP, Henry RJ, Faden AI, Loane DJ. Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells. J Neurotrauma 1;36(7):1040-1053, 2019. PMID 30259790.
  4. Sabirzhanov B, Faden A, Aubrecht T, Henry RJ, Stoica BA. miR-711 induced down-regulation of Angiopoietin-1 mediates neuronal cell death. J Neurotrauma. 15;35(20):2462-2481, 2018. PMID 29774773
  5. Ritzel R, Doran S, Barrett J, Henry RJ, Ma E, Faden A, Loane DL. Chronic alterations in systemic immune function after traumatic brain injury. J Neurotrauma 1;35(13):149-436, 2018. PMID 29421977.
  6. Barrett JP, Henry RJ, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury. J Neuroinflammation. 24; 14(1):65, 2017. PMID 28340575.
  7. Flannery LE, Henry RJ, Kerr DM, Finn DP, Roche M. FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signalling in the rat, independent of sex. J Neurosci Res. 20; 10. 1002, 2017. PMID 28726298.
  8. Lydon S, Healy O, Roche M, Henry RJ, Mulhern T, Hughes BM. Salivary cortisol levels and challenging behavior in children with autism spectrum disorder. Research in Autism Spectrum Disorders. Volume 10, 2015, Pages 78-92.
  9. Henry RJ, Kerr DM, Finn DP, Roche For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 4;64:167-80, 2016. PMID 25794989 (invited review).
  10. Henry RJ, Kerr DM, Flannery LE, Killilea M, Hughes EM, Corcoran L, Finn DP, Roche M#. Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1. Brain Behav Immun. 62:318-331, 2017. PMID 28237711.
  11. Henry RJ, Kerr DM, Finn DP, Roche FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. J Neuroimmunol. 15;276(1-2):126-34, 2014. PMID 25245162

Non-peer-reviewed journal articles

  1. Kerr DM, Henry R, Roche M. Anandamide Modulation of Endotoxin-Induced Inflammation. Anat Physiol 2013, 4:1(invited editorial).

 Manuscripts in preparation for peer-review (2019)

  1. Henry RJ, Ritzel RM, Doran SJ, Barrett JP, Faden AI, Loane DJ. Microglial depletion and repopulation during the chronic stages of experimental traumatic brain injury in mice improves long-term neurological recovery and reduces chronic neurodegeneration
  2. Henry RJ, Meadows VE, Loane DJ. Longitudinal assessment of sensorimotor behaviour following experimental traumatic brain injury.
  3. Barrett JP, Henry RJ, Doran SJ, Vogel SN, Faden AI, Loane DJ. Type I interferons drive pro-inflammatory neuroinflammation and neurodegenderation following experimental TBI in mice.
  4. Bhat S, Henry RJ, Ciesinski A, Stoica BA, Loane DJ, and Faden AI. Enhanced Akt/GSK-3b/CREB signaling underlies the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury
  5. Ritzel RM, Henry RJ, Doran SJ, Faden AI, Loane DJ. Aging microglial deletion and repopulation erases cellular dysfunction
  6. Doran SJ, Shirey KA, Henry RJ, Barrett JP, Ritzel RM, Lai W, Blanco J, Faden AI, Vogel SN, Loane DJ. Traumatic brain injury-induced immunosuppression inhibits monocyte response and increases mortality to Streptococcus pneumoniae lung infection.
  7. Ritzel, RM, Doran SJ, Henry RJ, Meadows V, Faden AI, Loane, DJ. Bone marrow progenitor cells exhibit dysfunction following TBI associated with motor and memory deficits
  8. Doran SJ, Ritzel RM, Henry RJ, Barrett JP, Braganca N, Polster B, Faden AI, Loane DJ. Lasting behavioral deficits coincide with chronic inflammatory and endothelial dysfunction one year after TBI

 Published abstracts

  1. Burke NN, Henry R, Chui S, Finn DP, Roche M (2012). Alterations in nociceptive responding and prefrontal chemokines expression in a rat model of depression: effects of chronic amitriptyline. European Neuropsychopharmacology Vol 22 Supplement 2, Pages S120-S121
  2. Burke NN, Henry R, Chui S, Finn DP, Roche M (2012). Alterations in nociceptive responding and prefrontal chemokines expression in a rat model of depression: effects of chronic amitriptyline. European Neuropsychopharmacology Vol 22 Supplement 1 Pages S37-S38
  3. Henry R, Kerr DM, Finn DP, Roche M (2012). Pharmacological inhibition of FAAH alters poly I:C-induced increases in cytokine expression in the rat Irish Journal of Medical Science, volume 182, Issue 4 supplement, pp 117-142. ISSN: 1863-4362
  4. Henry R, Kerr DM, Finn DP, Roche M (2012). TLR-3 mediated cytokine expression in the rat hippocampus is altered following pharmacological inhibition of FAAH. 22nd Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, P3-32.
  5. Henry R, Kerr DM, Finn DP, Roche M (2013). Central inhibition of fatty acid amide hydrolase attenuates TLR-3 induced expression of interferon-gamma and related genes in the In press
  6. Henry R, Kerr DM, Finn DP, Roche M (2013). Central inhibition of fatty acid amide hydrolase modulates expression of inflammatory mediators in discrete brain regions following a systemic bacterial BPS conference abstracts pA2 online. ISSN: 1741-1157
  7. Henry R, Kerr DM, Finn DP, Roche M (2014). N-acylethanolamines modulate early but not late phase neuroinflammatory responses to TLR-3 activation. European Neuropsychopharmacology Volume 24, Supplement 1, Pages S11 (March 2014), P.1.010. 1016/S0924-977X(14)70012-4
  8. Henry R, Kerr DM, Finn DP, Roche M (2014). FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. 24th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, P3-10.
  9. Flannery L, Henry R, Kerr DM, Finn DP, Roche M (2014). Sex-dependent alterations in locomotor activity and interferon expression following TLR3 activation. Irish Journal of Medical Sciences (in press)
  10. Henry R, Kerr DM, Finn DP, Roche M (2014). FAAH mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. Irish Journal of Medical Sciences (in press)
  11. Henry R, Kerr DM, Finn DP, Roche M (2014). FAAH inhibition modulates TLR3-induced inflammatory responses in the periphery and brain: possible role for CB1 Journal of Neuroimmunology Volume 276, Issue 1-2, pages 126-134 (15 November 2014) Proceedings of the XII International Congress of Neuroimmunology (ISNI)

 Proffered Communications 

  1. Henry R, Kerr D, Finn DP, Roche M (2012). Receptor mechanisms underlying the effects of fatty acid amide hydrolase inhibition on TLR-3 induced cytokine expression in the rat frontal cortex. 7th Annual Neuroscience Ireland Meeting, Royal College of Surgeons, Dublin (Poster).
  2. Henry R, Kerr D, Finn DP, Roche M (2012). Receptor mechanisms underlying the effects of fatty acid amide hydrolase inhibition on TLR-3 induced cytokine expression in the rat frontal cortex. Galway Neuroscience Research Day, NUIG (Poster).
  3. Henry R, Ni Fhatharta C, Kerr D, Finn DP, Roche M (2013). Inhibition of fatty acid amide hydrolase does not modulate TLR-3 induced neuroinflammation or reductions in hippocampal BDNF expression. 8th Annual Neuroscience Ireland Meeting, UCC, Cork (poster).
  4. Henry R, Kerr D, Finn DP, Roche M (2013). Central inhibition of fatty acid amide hydrolase modulates expression of inflammatory mediators in discrete brain regions following a systemic bacterial infection. Presented at College of Science Research Day, NUIG, April (Poster).
  5. Henry R, Kerr D, Finn DP, Roche M (2013). Central inhibition of fatty acid amide hydrolase modulates expression of inflammatory mediators in discrete brain regions following a systemic bacterial infection.  College of Medicine Research Day, NUIG, May 2013 (Poster).
  6. Henry R, Kerr D, Finn DP, Roche M (2013). Inhibition of Fatty acid amide hydrolase does not modulateTLR3-induced neuroinflammation or reductions in hippocampal BDNF expression (2013). Young Life Scientists’ Symposium 2013 – Cell signalling (Poster).
  7. Henry R, Kerr DM, Finn DP, Roche M . Central inhibition of fatty acid amide hydrolase attenuates TLR-3 induced expression of interferon-gamma and related genes in the rat (2013). Galway Neuroscience Research Day, NUIG (Poster).
  8. Henry R, Kerr D, Finn DP, Roche M (2014) N-acylethanolamines modulate early but not late phase neuroinflammatory responses to TLR-3 activation. Presented at Young Life Scientists, Ireland, TCD, Dublin (Poster).
  9. Henry R, Kerr D, Finn DP, Roche M (2014). FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus. College of Medicine Research Day May 2014 (Talk).
  10. Henry R, Kerr D, Finn DP, Roche M (2014). FAAH inhibition modulates TLR3-induced inflammatory responses in the periphery and brain: possible role for CB1 Careers in Neuroscience Symposium, NUIG (poster).
  11. Flannery L, Henry RJ, Kerr DM, Finn DP, Roche M. TLR3-induced inflammatory responses in the hypothalamus are attenuated following FAAH, but not MAGL; an effect independent of sex. College of Medicine Research Day, NUIG, May 2015 (Poster).
  12. Fitzgibbon M, Henry RJ, Kerr DM, Finn DP, Roche M. Characterisation of the endocannabinoid system in the descending pain pathway in a mouse model of IFN-α induced hyperalgesia. College of Medicine Research Day, NUIG, May 2015 (Poster).
  13. Lydon, S., Healy, O., Roche, M., Henry, R., Mulhern, T., & Hughes, B. M. (2015).  Salivary cortisol levels and challenging behavior in children with autism spectrum disorder. 9th Annual Autism Conference of the Association for Behavior Analysis International (ABAI). Las Vegas, NV, USA (Poster).
  14. Henry R, Kerr D, Finn DP, Roche M (2015). Increasing Fatty acid amide hydolase substrates attenuates TLR4-induced neuroinflammation independent of central cannabinoid receptor activation. British Neuroscience Association (Poster).
  15. Henry RJ, Loane DJ, Sabirzhanov, Stoica, BA, Faden AI (2016). Administration of miR-155 antagomir following experimental traumatic brain injury (TBI) attenuates post-traumatic neuroinflammatory responses and improves neurological recovery. SFN (Poster)
  16. Henry RJ, Loane DJ, Barrett JP, Doran S, Sabirzhanov, Stoica, BA, Faden AI (2017). Delayed And Continual Central Infusion Of miR-155 Antagomir Is Associated With Attenuated Expression of Pro-inflammatory Mediators And Improvements In Motor Function Outcomes Following Experimental Traumatic Brain Injury. National Capital Area TBI Research Symposium (Poster)
  17. Henry RJ, Loane DJ, Barrett JP, Doran S, Sabirzhanov, Stoica, BA, Faden AI (2017). Delayed And Continual Central Infusion Of miR-155 Antagomir Is Associated With Attenuated Expression of Pro-inflammatory Mediators And Improvements In Motor Function Outcomes Following Experimental Traumatic Brain Injury. National Neurotrauma Society (Poster)
  18. Henry RJ, Ritzel RR, Barrett JP, Doran S, Stoica, BA, Faden AI, Loane DJ (2019). Microglia depletion and repopulation during the chronic stages of experimental traumatic brain injury in mice improves long-term neurological recovery and reduces chronic neurodegeneration. National Capital Area TBI Research Symposium (Oral communication)
  19. Henry RJ, Ritzel RR, Barrett JP, Doran S, Stoica, BA, Faden AI, Loane DJ (2019). Microglia depletion and repopulation during the chronic stages of experimental traumatic brain injury in mice improves long-term neurological recovery and reduces chronic neurodegeneration. The Department of Anesthesiology Research Retreat Program (Poster).