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Tracy H. Hazen, PhD

Academic Title:

Research Associate

Primary Appointment:

Microbiology and Immunology

Location:

Health Sciences Facility III, 670 West Baltimore St, Baltimore 21201

Phone (Primary):

410-706-2376

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Education and Training

B.S., 2004, University of California, Davis

Ph.D., 2009, Georgia Institute of Technology

 

Biosketch

During my Ph.D. I studied microbial ecology and the contribution of plasmids and phages to the genetic diversity of bacteria in coastal marine environments.  I developed an interest in learning bioinformatics techniques that lead me to do my postdoctoral training at the Institute for Genome Sciences with Dr. David Rasko.  Since starting at IGS I have been using comparative genomics and transcriptomics to investigate the genomic diversity of pathogenic E. coli.  I have also been investigating the antibiotic resistance mechanisms of Klebsiella and Acinetobacter species.  As a Research Associate at IGS I am interested in the genetic diversity of plasmids and their role in the development of disease and antibiotic resistance of enterics.

Research/Clinical Keywords

E. coli, genomics, evolution, antibiotic resistance

Highlighted Publications

    1. Hazen, T.H., J.W. Sahl, M.S. Donnenberg, C.M. Fraser, F. Scheutz, and D.A. Rasko.  2013.  Refining the pathovar paradigm via phylogenomics of the attaching and effacing Escherichia coli.  Proc. Natl. Acad. Sci. USA, 110:12810-12815. (PMID: 23858472)
    2. Subashchandrabose, S., T.H. Hazen, A.R. Brumbaugh, S.D. Himpsl, S.N. Smith, R.D. Ernst, D.A. Rasko, and H. Mobley.  2014.  Human-specific induction of Escherichia coli fitness genes during clinical urinary tract infection.  Proc. Natl. Acad. Sci. USA 111: 18327-32. (PMID: 25489107)
    3. Hazen, T.H., L. Zhao, M.A. Boutin, G. Robinson, A.D. Harris, D.A. Rasko, and J.K. Johnson.  2014.  Comparative genomics of an IncA/C multidrug resistance plasmid from Escherichia coli and Klebsiella species isolated from ICU patients: the utility of whole genome sequencing in healthcare settings.  Antimicrob. Agents Chemother. 58: 4814-4825. (PMID: 24914121)
    4. Hazen, T.H., J.B. Kaper, J.P. Nataro, and D.A. Rasko.  2015.  Comparative genomics provides insight into the diversity of the attaching and effacing Escherichia coli (AEEC) virulence plasmids. Infect. Immun. 83:4103-4117. (PMID: 26238712)
    5. Hazen, T.H., M.S. Donnenberg,S. Panchalingam, M. Antonio, A. Hossain, I. Mandomando, J.B. Ochieng, T. Ramamurthy, B. Tamboura, S. Qureshi, F. Quadri, A. Zaidi, K.L. Kotloff, M.M. Levine, E.M. Barry, J.B. Kaper, D.A. Rasko, and J.P. Nataro.  2016.  Genomic diversity of EPEC associated with clinical presentations of differing severity.  Nat. Microbiol. (PMID: 27571975)

    Additional Publication Citations

    1. Hazen, T.H., D. Wu, J.A. Eisen, and P.A. Sobecky.  2007.  Sequence characterization and comparative analysis of three plasmids isolated from environmental Vibrio spp.  Appl. Env. Microbiol. 73:7703-7710. (PMID: 17921277)
    2. Criminger, J.D., T.H. Hazen, P.A. Sobecky, and C.R. Lovell.  2007.  Nitrogen fixation by Vibrio parahaemolyticus and its implications for a new ecological niche.  Appl. Env. Microbiol.73:5959-5961. (PMID: 17675440)
    3. Hazen, T.H., K.D. Kennedy, S. Chen, S.V. Yi, and P.A. Sobecky.  2009. Inactivation of mismatch repair increases the diversity of Vibrio parahaemolyticus.  Environ. Microbiol. 11:1254-1266. (PMID: 19161434)
    4. Sobecky, P.A., and T.H. Hazen.  2009.  Horizontal gene transfer and mobile genetic elements in marine systems.  Horizontal gene transfer:  genomes in flux.  Humana Press.  Eds. M.B. Gogarten et al. 532:435-453. (PMID: 19271200)
    5. Hazen, T.H., R.J. Martinez, Y. Chen, P.C. Lafon, N.M. Garrett, M.B. Parsons, C.A. Bopp, M.C. Sullards, and P.A. Sobecky.  2010.  Rapid identification of Vibrio parahaemolyticus by whole-cell matrix assisted laser desorption ionization-time of flight mass spectrometry.  Appl. Environ. Microbiol.75:6745-6756. (PMID: 19749061)
    6. Hazen, T.H., L. Pan, J.D. Gu, and P.A. Sobecky.  2010.  Contribution of mobile genetic elements to the ecology and evolution of Vibrios.  FEMS Microbiol. Ecol.Review. 74:485-499. (PMID: 20662928)
    7. Hazen, T.H., G. Robinson, A.D. Harris, D.A. Rasko, J.K. Johnson.  2012.  Genome sequence of Klebsiella oxytoca 11492-1, a nosocomial isolate possessing a FOX-5 AmpC β-lactamase.  J. Bacteriol. 194:3028-3029. (PMID: 22582383)
    8. Hazen, T.H., J.W. Sahl, J. Redman, C. Morris, S. Daugherty, M. Chibucos, N. Sengamalay, C. Fraser-Liggett, H. Steinsland, T. Whittam, B. Whittam, S. Manning, and D.A. Rasko.  2012.  Draft genome sequence of diarrheagenic Escherichia coli collection.  J. Bacteriol.  194:3026-3027. (PMID: 22582382)
    9. Subashchandrabose, S., T.H. Hazen, D.A. Rasko, and H. Mobley.  2013.  Draft genome sequences of five recent human uropathogenic Escherichia coli isolates.  Pathogens Dis. (PMID: 23821517)
    10. Nisa, S., T.H. Hazen, L. Assatourian, J.P. Nougayrède, D.A. Rasko, and M.S. Donnenberg.  2013.  In vitro evolution of an archetypal enteropathogenic Escherichia coli strain. J. Bacteriol. 195:4476-4483. (PMID: 23913321)
    11. Hazen, T.H., J.W. Sahl, C.M. Fraser, M.S. Donnenberg, F. Scheutz, and D.A. Rasko.  2013.  Draft genome sequences of three O157 enteropathogenic Escherichia coli isolates.  Genome Announc.  (PMID: 23868135)
    12. Hazen, T.H., J.W. Sahl, M.S. Donnenberg, C.M. Fraser, F. Scheutz, and D.A. Rasko.  2013.  Refining the pathovar paradigm via phylogenomics of the attaching and effacing Escherichia coli.  Proc. Natl. Acad. Sci. USA, 110:12810-12815. (PMID: 23858472).
    13. Levine, J.A., A.M. Hansen, J.M. Michalski, T.H. Hazen, D.A. Rasko, and J. Kaper.  2014.  H-NST induces LEE expression and the formation of attaching and effacing lesions in enterohemorrhagic Escherichia coli. Plos One, 9(1):e86618.  (PMID: 24466172)
    14. Sanjar, F., T. Hazen, S. Shah, S. Koenig, S. Agrawal, S. Daugherty, L. Sadzewicz, L. Tallon, M. Mammel, P. Feng, R. Soderlund, P. Tarr, C. DebRoy, E. Dudley, T. Cebula, J. Ravel, C. Fraser, D. Rasko, and M. Eppinger.  2014.  Genome sequence of Escherichia coli O157:H7 strain 2886-75 associated with the first reported case of human infection in the United States. Genome Announc. 2: e01120-13.  (PMID: 24407635)
    15. Hazen, T.H., L. Zhao, J.W. Sahl, G. Robinson, A.D. Harris, D.A. Rasko, and J.K. Johnson.  2014. Characterization of Klebsiella sp. 10982, a colonizer of humans that contains novel antibiotic resistance alleles and exhibits genetic similarities to plant and clinical Klebsiella isolates.  Antimicrob. Agents Chemother.  58: 1879-88. (PMID: 24395222)
    16. Hazen, T.H., L. Zhao, M.A. Boutin, G. Robinson, A.D. Harris, D.A. Rasko, and J.K. Johnson.  2014.  Comparative genomics of an IncA/C multidrug resistance plasmid from Escherichia coli and Klebsiellaspecies isolated from ICU patients: the utility of whole genome sequencing in healthcare settings.  Antimicrob. Agents Chemother. 58: 4814-4825. (PMID: 24914121)
    17. Hazen, T.H., M.S. Humphrys, B. Ochieng, M. Parsons, C.A. Bopp, E. Mintz, C. O’Reilly, and D.A. Rasko.  2014.  Draft genome sequences of nine enteropathogenic Escherichia coli from Kenya.  Genome Announc. e00582-14 (PMID: 24926061)
    18. Sadiq, S.M., T.H. Hazen, D.A. Rasko, M. Eppinger.  2014.  EHEC Genomics: Past, present and future.  Microbiol. Spectr.  (PMID: 26104203)
    19. Doi, Y., T.H. Hazen, M. Boitano, Y-C. Tsai, T.A. Clark, J. Korlach, D.A. Rasko.  2014.  Whole genome assembly of a Klebsiella pneumoniae strain co-producing NDM-1 and OXA-232 carbapenemases using single-molecule, real-time sequencing.  Antimicrob. Agents Chemother. 58: 5947-53. (PMID: 25070096)
    20. Subashchandrabose, S., T.H. Hazen, A.R. Brumbaugh, S.D. Himpsl, S.N. Smith, R.D. Ernst, D.A. Rasko, and H. Mobley.  2014.  Human-specific induction of Escherichia coli fitness genes during clinical urinary tract infection.  Proc. Natl. Acad. Sci. USA 111: 18327-32. (PMID: 25489107)
    21. Brumbaugh, A., S. Smith, S. Subashchandrabose, S. Himpsl, T. Hazen, D. Rasko, and H. Mobley.  2015.  Blocking yersiniabactin import attenuates extraintestinal pathogenic Escherichia coli in cystitis and pyelonephritis and represents a novel target to prevent urinary tract infection.  Infect. Immun. 83: 1443-50. (PMID: 25624354)
    22. Hazen, T.H., P.C. Lafon, N.M. Garrett, T.M. Lowe, D.J. Silberger, L.A. Rowe, M. Frace, M.B. Parsons, C.A. Bopp, D.A. Rasko, and P.A. Sobecky.  2015.  Insights into the environmental reservoir of pathogenic Vibrio parahaemolyticus using comparative genomics.  Front. Microbiol. (PMID: 25852665)
    23. Donnenberg, M., T.H. Hazen, T.H. Farag, S. Panchalingam, M. Antonio, A. Hossain, I. Mandomando, J.B. Ochieng, T. Ramamurthy, B. Tamboura, A. Zaidi, M.M. Levine, K. Kotloff, D.A. Rasko, and J.P. Nataro.  2015.  Bacterial factors associated with lethal outcome of enteropathogenic Escherichia coli infection: genomic case-control studies.  Submitted to Plos Negl. Trop. Dis. (PMID: 25978422)
    24. Sanjar, F., B. Rusconi, T. Hazen, S. Eppinger, M. Mammel, P. Feng, D. Rasko, and M. Eppinger.  2015.  Characterization of the pathogenome and phylogenomic classification of enteropathogenic Escherichia coli of the O157:non-H7 serotypes.  Pathog. Dis. (PMID: 25962987)
    25. Hazen, T.H., S.C. Daugherty, A.C. Shetty, A.A. Mahurkar, O. White, J.B. Kaper, and D.A. Rasko.  2015.  RNA-Seq analysis of isolate- and growth phase-specific differences in the global transcriptomes of enteropathogenic Escherichia coli prototype strains.  Front. Microbiol. (PMID: 26124752)
    26. Hazen, T.H., J.B. Kaper, J.P. Nataro, and D.A. Rasko.  2015.  Comparative genomics provides insight into the diversity of the attaching and effacing Escherichia coli (AEEC) virulence plasmids. Infect. Immun. 83:4103-4117. (PMID: 26238712)
    27. Kessler, R., S. Nisa, T.H. Hazen, A. Horneman, A. Amoroso, D.A. Rasko, and M.S. Donnenberg.  2015.  Diarrhea, bacteremia and multiorgan dysfunction due to an extraintestinal pathogenic Escherichia coli strain with divergent enteropathogenic E. coli genes. Pathog. Dis. (PMID: 26410828)
    28. Hazen, T.H., M.S. Donnenberg,S. Panchalingam, M. Antonio, A. Hossain, I. Mandomando, J.B. Ochieng, T. Ramamurthy, B. Tamboura, S. Qureshi, F. Quadri, A. Zaidi, K.L. Kotloff, M.M. Levine, E.M. Barry, J.B. Kaper, D.A. Rasko, and J.P. Nataro.  2016.  Genomic diversity of EPECassociated with clinical presentations of differing severity.  Nat. Microbiol. (PMID: 27571975)
    29. Kania, D.A., T.H. Hazen, A. Hossain, J.P. Nataro, and D.A. Rasko.  2016.  Genome dynamics of Shigella boydii.  Pathog. Dis. (PMID: 27056949)
    30. Hazen, T.H., S.R. Leonard, K.A. Lampel, D.W. Lacher, A.T. Maurelli, and D.A. Rasko.  2016.  Investigating the relatedness of enteroinvasive Escherichia coli to other E. coli and Shigella using comparative genomics.  Infect. Immun. 84:2362-71 (PMID: 27271741)
    31. Chibucos, M.C., S. Soliman, T. Ghebremarimam, H. Lee, S. Daugherty, J. Orvis, A.C. Shetty, J. Crabtree, T.H. Hazen, K.A. Etienne, P. Kumari, T.D. O’Connor, D.A. Rasko, C.M. Fraser, S.R. Lockhart, C.D. Skory, A.S. Ibrahim, and V.M. Bruno.  2016.  An integrated genomic and transcriptomic survey of mucormycosis-causing fungi.  Nat. Commun. (PMID: 27447865)
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