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Anuj Gupta, MD, F.A.C.C., F.S.C.A.I.

Academic Title:

Associate Professor

Primary Appointment:

Medicine

Administrative Title:

Director Of The Cath Lab

Location:

Paca Pratt, 7-S-162

Phone (Primary):

(410) 328-9098

Fax:

(410) 328-1717

Education and Training

1994  B.A. Biology, Johns Hopkins University, Baltimore, MD

1998  M.D., University of Maryland School of Medicine, Baltimore, MD

1998 – 2001  Internship/Residency, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY

2001 - 2003   Fellowship, Weill Medical College, Cornell University, New York, NY

Howard Gilman Institute for Valvular Heart Disease Cardiovascular Research Fellow, Division of  Cardiovascular Pathophysiology, Department of Medicine             

2003 - 2006   Cardiology Fellowship, Temple University Hospital

2006 – 2008   Fellowship, Interventional Cardiology, New York Presbyterian Hospital, Columbia University Medical Center 

Biosketch

Anuj Gupta, MD, is an Associate Professor at the University of Maryland School of Medicine. An interventional cardiologist, he serves as director of the Cardiac Catheterization Laboratory at the University of Maryland School of Medicine. His primary focus is on the treatment of severe aortic stenosis in patients who are eligible for transcatheter aortic valve replacement (TAVR). In his role evaluating TAVR and related therapies, he is the site principal investigator for the PARTNER 2 trial, Early TAVR Trial, Galileo Trial, and the Medtronic low-risk, randomized trial for TAVR. In addition, he is involved in renal denervation studies, including the SYMPLICITY-HTN3 trial and Reduce HTN: Reinforce trial.

He is a past Governor of the Maryland Chapter of the American College of Cardiology, the professional society for cardiologists and related cardioavascular specialists. He is a principal in the Maryland Academic Consortium for Percutaneous Coronary Intervention Appropriateness and Quality (MACPAQ), a joint initiative between Johns Hopkins University School of Medicine and the University of Maryland School of Medicine to create a system of external peer review for PCI in the state of Maryland. External peer review, a state requirement for providing PCI services, demonstrates that hospitals in Maryland are providing appropriate, high-quality PCI services.

Research/Clinical Keywords

Aortic Stenosis TAVR Aortic Balloon Valvuloplasty Acute Coronary Syndrome

Highlighted Publications

  1. Guo L, Akahori H, Harari E1, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R1, Mori H1, Kutyna MD1, Torii S1, Sakamoto A1, Choi CU2, Cheng Q1, Grove ML6, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV.  CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.  J Clin Invest. 2018 Feb 19.
  2. Gupta A, Yeh R, Tamis-Holland JE, Patel SH, Guyton RA, Klein LW, Rab T, Kirtane AJ.  Implications of Public Reporting of Risk-
  3. Adjusted Mortality following PCI: Misperceptions and Potential Consequences for High-Risk Patients including the Non-Surgical Patient.  JACC Intervention  Accepted  August 11th, 2016
  4. Ghasemi Z, Kim CS, Ginsberg E, Duell J, Gupta A, Hahn JH.  Estimation of Central Aortic Blood Pressure From Non-Invasive Cuff Pressure Oscillation Signals Via System Identification.  Dynamic Systems and Controls Conference, Proceedings of the ASME.  October 12-14, 2016
  5. Kirtane AJ, Gupta A, Iyengar S, Moses JW, Leon MB, Applegate R, Brodie B, Hannan E, Harjai K, Jensen LO, Park SJ, Perry R, Racz M, Saia F, Tu JV, Waksman R, Lansky AJ, Mehran R, Stone GW.  Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies.  Circulation. 2009 Jun 30;119(25):3198-3206
  6. Gupta A, Mancini D, Kirtane AJ, Kaple RK, Apfelbaum MA, Kodali SK, Marboe C, Leon MB, Moses JW, Rabbani LE.  Value of drug-eluting stents in cardiac transplant recipients.  Am J Cardiol. 2009 Mar 1;103(5):659-66

Additional Publication Citations

  1. Jain VK, Gupta A, Magrath IT.  A rapid screening method for bacteria containing firefly luciferase plasmids. Biotechniques, 1993 Oct; 15(4): 600-2
  2. Gupta A, Carter JN, Truter SL, Leer EH, Herrold EM, Borer JS.  Cellular response of human cardiac fibroblasts to mechanically simulated aortic regurgitation.  Am J Ther. 2006 Jan-Feb; 13 (1): 8-11.  
  3. Supino PG, Borer JS, Schuleri K, Gupta A, Hochreiter C, Kligfield P, Herrold EM, Preibisz JJ.  Prognostic value of exercise tolerance testing in asymptomatic chronic nonischemic mitral regurgitation.   Am J Cardiol. 2007 Oct 15;100(8):1274-81
  4. Solinas E, Dangas G, Kirtane AJ, Lansky AJ, Franklin-Bond T, Boland P, Syros G, Kim YH, Gupta A, Mintz G, Fahy M, Collins M, Kodali S, Stone GW, Moses JW, Leon MB, Mehran R.  Angiographic patterns of drug-eluting stent restenosis and one-year outcomes after treatment with repeated percutaneous coronary intervention.  Am J Cardiol. 2008 Aug 1;102(3):311-315
  5. Gupta A, Mancini D, Kirtane AJ, Kaple RK, Apfelbaum MA, Kodali SK, Marboe C, Leon MB, Moses JW, Rabbani LE.  Value of drug-eluting stents in cardiac transplant recipients.  Am J Cardiol. 2009 Mar 1;103(5):659-662
  6. Kirtane AJ, Gupta A, Iyengar S, Moses JW, Leon MB, Applegate R, Brodie B, Hannan E, Harjai K, Jensen LO, Park SJ, Perry R, Racz M, Saia F, Tu JV, Waksman R, Lansky AJ, Mehran R, Stone GW.  Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies.  Circulation. 2009 Jun 30;119(25):3198-3206
  7. Sanidas EA, Maehara A, Mintz GS, Kubo T, Gupta A, Apfelbaum MA, Hakim D, Moses JW, Mancini DM, Rabbani LE. Volumetric intravascular ultrasound assessment of mechanisms and results of stent expansion in heart transplant patients. Catheter Cardiovasc Interv. 2012 Mar 28
  8. Remo BF, Preminger M, Bradfield J, Mittal S,  Boyle N, Gupta A, Shivkumar K, Steinberg JS, Dickfeld T.  Safety and Efficacy of Renal Denervation as a Novel Treatment for Ventricular Tachycardia Storm in Patients with Cardiomyopathy.  Heart Rhythm 2014 Apr;11(4):541-546
  9. Gupta A, Yeh R, Tamis-Holland JE, Patel SH, Guyton RA, Klein LW, Rab T, Kirtane AJ.  Implications of Public Reporting of Risk-Adjusted Mortality following PCI: Misperceptions and Potential Consequences for High-Risk Patients including the Non-Surgical Patient.  JACC Intervention  Accepted  August 11th, 2016
  10. Ginsberg E, Chahal D, Kligerman S, Jeudy J, Seliger S, George P, Storck C, Meeks A, Srivastava M, Stafford L, Vesely M, Lee T, Gupta A.  Low Contrast Dose CTA for TAVR Evaluation Using a Central PA Catheter.  Submitted, Cardiology 2016. 

 

Non Peer Reviewed Journal Articles

  1. Borer JS, Truter S, Herrold EM, Supino PG, Carter JN, Gupta A.  The cellular and molecular basis of heart failure in regurgitant valvular diseases: the myocardial extracellular matrix as a building block for future therapy.  Advances in Cardiology 2002; 39: 7-14.
  2. Borer J, Supino P, Truter S, Herrold E, Hochreiter C, Gupta A, Yin A, Lee E, Pitlor L, Krieger K, Isom O. Aortic regurgitation: contractility as primary prognosticator and basis of the contractile deficit. Proceedings of 3rd International Congress on Heart Disease – New Trends in Research, Diagnosis and Treatment (Kimchi A, ed), Monduzzi Editore (Bologna), 2003, pp. 449-453.
  3. Supino, PG, Schuleri K, Gupta A, Borer JS. Management of valvular heart disease in the elderly. Cardiology Review 2003;20:24-31.
  4. Borer JS, Truter SL, Gupta A, Herrold EM, Carter JN, Lee E, Pitlor L.  Heart failure in aortic regurgitation: the role of primary fibrosis and its cellular and molecular pathophysiology.  Adv Cardiol. 2004; 41: 16-24.
  5. Gupta A, Burke JA, and Bove A.  Coronary Artery Revascularization—Past, Present Future. Part 1: Historical Trials.  Clin. Cardiol. 29, 341–344 (2006)
  6. Gupta A, Burke JA, and Bove A.  Coronary Artery Revascularization—Past, Present Future. Part 2: Newer Technologies.  Clin. Cardiol. 29, 290–294 (2006)
  7. Gupta A, Bersin R.  Percutaneous Treatment of Abdominal Aortic Aneurysms.  Science Innovation Synergy Yearbook 2007, Chapter 10.
  8. Gupta A, Moussa I.  Clinical Outcomes following Use of Sirolimus Eluting Stents: An Update.  In: Interventional Cardiology.  London, England: Touch Cardiology, October 2007: 31-34.
  9. Truter SL, Catanzaro DF, Supino PG, Gupta A, Carter J, Herrold EM, Dumlao TF, Borer JS.  Differential expression of matrix metalloproteinases and tissue inhibitors and extracellular matrix remodeling in aortic regurgitant hearts.  Cardiology. 2009;113(3):161-168
  10. Truter SL, Catanzaro DF, Supino PG, Gupta A, Carter J, Ene AR, Herrold EM, Dumlao TF, Beltran F, Borer JS.  Fibronectin gene expression in aortic regurgitation: relative roles of mitogen-activated protein kinases.  Cardiology. 2009;113(4):291-298
  11. Cilingiroglu M, Gupta A.  The laa occlusion paradigm: are we there yet?  Catheter Cardiovasc Interv. 2011 Nov 15;78(6):974-5
  12. Godiwala T, Srivastava M, Gupta A.  Reperfusion Strategies and Systems of Care in ST- Elevation Myocardial Infarction.  Cardiology Clinics 2012: 30 (4), 629-637
  13. Motwani M, Motlagh M, Gupta A, Berman DS, Slomka P.  Reasons and implications of agreements and disagreements between coronary flow reserve, fractional flow reserve, and myocardial perfusion imaging.  Journal of Nuclear Cardiology.  Online December 29, 2015
  14. Rollor J, Feldmeier R, Jerome S, Gupta A.  Reconciling discordant myocardial perfusion imaging and coronary angiography.  Journal of Nuclear Cardiology.  Accepted December 18th, 2015
  15. Gupta A, Rajagopalan S.  Letter by Gupta regarding article, "Coronary Heart Disease Mortality Declines in the United States From 1979 Through 2011: Evidence for Stagnation in Young Adults, Especially Women".  Circulation.  Accepted November 29th, 2015
  16. Ghasemi Z, Kim CS, Ginsberg E, Duell J, Gupta A, Hahn JH.  Estimation of Central Aortic Blood Pressure From Non-Invasive Cuff Pressure Oscillation Signals Via System Identification.  Dynamic Systems and Controls Conference, Proceedings of the ASME.  October 12-14, 2016

Research Interests

Multicenter clinical trials evaluating the efficacy of transcatheter aortic valve replacement systems for the treatment of severe, symptomatic aortic stenosis in patients at various risk for surgical aortic valve replacement forms the bulwark of my research efforts.

In addition, efforts to reduce renal toxicity by contrast preservation methods in patients being evaluated for TAVR has formed a secondary interest.  These patients, often elderly with renal dysfunction, benefit from efforts to reduce contrast exposure.

As external peer review establishes itself in the state of Maryland, future efforts will evaluate Appropriate Use Criteria in the context of interventional cardiology reviewed PCI procedures.

Clinical Specialty Details

My main clinical specialties include treatment of coronary disease for acute coronary syndrome, cardiogenic shock, and cardiac arrest, as well as patients declined by cardiac surgery due to patient's high surgical risk.  In addition, I have established, since its inception and along with my surgical colleagues, the Transcatheter Aortic Valve Replacement program at the University of Maryland.

Awards and Affiliations

2001  Outstanding Achievement in the Teaching of Medical Students, Leo M. Davidoff Society of the Albert Einstein College of Medicine of Yeshiva University

2012  Teacher of the Year Award, University of Maryland Division of Cardiology 

2008-Present  Fellow of the American College of Cardiology

2008-Present  Fellow of the Society for Coronary Angiography and Intervention