Epidemiology & Public Health
Howard Hall, 111
Education and Training
M.Sc., Fellowship and Assistantship Dalhousie University, Halifax, Nova Scotia, Canada
Ph.D., confirmed and approved by University of Toronto, Toronto, Canada by Comparative Education Service of Canada
Ph.D., State Technical University, Moscow, Russia, Engineering: Optimization of industrial processes
M.Sc., B.S., National University of Science and Technology, Moscow, Russia, Engineering: Development of advanced materials and technologies
Dr. Goloubeva's work focuses on the design and statistical analysis of preclinical studies and Phase I-III clinical trials; evaluation of diagnostic tests, biomarkers, and their combination; prognostic models of cancer and other diseases; longitudinal and hierarchical data modeling; and integration of data from proteomics and genomics into modeling of cancer patients' survival experience. She has been using a wide variety of biostatistical methods for quantitative cancer research augmented by knowledge of the principles of cancer biology and clinical management of cancer. Her special interest lies in designs and biomarker discovery studies including the analysis of high-dimensionality data sets and longitudinal modeling of marker changes in response to therapy. Recently, she developed interest in using population-based cancer registries linked SEER-Medicare database with claim information to study treatment of cancer, outcomes, and cost with the emphasis on disparities. The ongoing collaboration in research of many different cancers and diseases is reflected in her more than100 peer-reviewed publications since 2000.
Clinical trial design, population-based databases, bio-statistics
Aaron P. Rapoport, Edward A. Stadtmauer, Gwendolyn K. Binder-Scholl, Olga Goloubeva, Dan T. Vogl, Simon Lacey, Ashraf Z. Badros, Alfred Garfall, BrendanWeiss, Jeffre Finklestein, Irina Kulikovskaya, Sanjoy K. Sinha, ShariKronsberg, Minnal Gupta, Sarah Bond, Luca Melchiori, Joanna E. Brewer, AlanD. Bennett, Andrew B. Gerry, Nick J. Pumphrey, Daniel Williams, Helen K. Tayton-Martin, Lilliam Ribeiro, Tom Holdich, Saul Yanovich, Nancy Hardy, Jean Yared,Naseem Kerr, Sunita Philip, Sandra Westphal, Don L. Siegel, Bruce L. Levine, Bent K. Jakobsen, Michael Kalos, and Carl H. June. NY-ESO-1 specific engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma. Nature Medicine. 2015 Aug; 21(8): 914-21.(Data analysis, manuscript writing).
Weinstock C, Campassi C, Goloubeva O,Wooten K, Kesmodel S, Bellevance E, Ioffe O, Fiegenberg S, Tkaczuk KH. Breast magnetic resonance imaging (MRI) surveillance in breast cancer survivors. Springerplus. 2015 Aug 28; 4: 459. (Data analysis, manuscript writing).
Schech AJ, Yu S, Goloubeva O, McLenithan J, Sabnis GJ. A nude mouse model of obesity to study the mechanisms of resistance to aromatase inhibitors. Endocr Relat Cancer. 2015; Aug; 22(4): 645-56. (Data analysis, manuscript writing).
Evans CF, Iacono AT, Sanchez PG, Goloubeva O, Kim J, Timofte I, Chema FN, Pham SM, Grifith BP, Rajagopal K. Venous Thromboembolic Complications of Lung Transplantation: A Contemporary Single Institution Review. Ann Thorac Surg. 2015 Dec; 100(6): 2033-9. (Data analysis, manuscript writing).
Onukwugna E, Petrelli N, Castro KM, Gardner JF, Jayasekera J, Goloubeva O, Tan MT, McNamara E, Zaren H, Asfeld T, Bearden J, Salner A, Krasna M, Das IP, Clauser SB. ReCAP: Impact of multidisplinary care on processes of cancer care: a multi-institutional study. J Oncol Pract. 2016 Feb; 12(2): 155-156.
Zandberg DP, Liu S, Goloubeva O, Ord R, Strome SE, Suntharalingam M, Taylor R, Morales RE, Wolf JS, Zimrin A, Schumaker LM, Cullen KJ. Orapharungeal cancer (OPC) drives racial outcome disparities in squamous cell carcinoma of the head and neck (HNSCC): Ten year experience at the University of Maryland Greenebaum Cancer Center (UMGCC). Head and Neck. 2016 Apr; 38(4): 564-72. (Data analysis, manuscript writing).
Dancy JG, Wadajkar AS, Schneider CS, Mauban JR, Goloubeva OG, Woodworth GF, Winkles JA, Kim AJ. Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue.J Control Release. 2016 Jul 25; 238:139-148. (Data analysis, manuscript writing).
Kesmodel SB, Goloubeva OG, Rosenblatt PY, Heiss B, Bellavance EC, Chumsri S, Bao T, Thompson J, Nightingale G, Tait NS, Nichols EM, Feigenberg SJ, Tkaczuk KH. Patient-reported Adherence to Adjuvant Aromatase Inhibitor Therapy Using the Morisky Medication Adherence Scale: An Evaluation of Predictors.Am J Clin Oncol. 2016 Jun 17.
Kochel TJ, Goloubeva OG, Fulton AM. Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer. Breast Cancer (Auckl). 2016 May 25;10:61-70.
Jung S, Goloubeva O, Klifa C, LeBlanc ES, Snetselaar LG, Van Horn L, Dorgan JF. Dietary Fat Intake During Adolescence and Breast Density Among Young Women.Cancer Epidemiol Biomarkers Prev. 2016 Jun;25(6):918-26.0
Dr. Goloubeva's work focuses on the design and statistical analysis of preclinical studies and Phase I-III clinical trials; evaluation of diagnostic tests, biomarkers, and their combination; and prognostic models of cancer. Her main research interests include longitudinal and hierarchical data modeling; applied biostatistics; and integration of data from proteomics and genomics into modeling of cancer patients' survival experience.
Ethnic disparities in health care utilization among African American, Hispanic and Causian survivors of multiple myeloma and head and neck cancer
Behavioral treatment for low-income depressed smokers in the community
Inhibition of Pim Kinases in Acute Myeloid Leukemia
Transcriptional Regulation of Tumor Growth
Role of MicroRNAs in the Regulation of Chronic Myeloid Leukemia Stem Cell Survival and Self Renewal
American Institute for Cancer Research
Prospective Study of Diet in Youth and Adult Breast Density
The objective of this study is identify dietary factors in youth that influence breast density.
National Cancer Institute (NCI)
University of Maryland Cancer Center Support Grant
The goal of this grant is to provide infrastructure support to the University of Maryland UMGCC.
Mechanisms for sensitivity to PARP inhibitors in cancers involving ALT NHEJ
Local and National Service
- Reviewer, Cancer, Cancer Research, 2005-Present
- Reviewer, Cancer Chemotherapy and Pharmacology, 2011-Present
- Reviewer, Journal of Cancer Education, 2016-Present
- Statistical Consultant, NIH/NIA, 2008-2010
- Member, DSM Board for NIH/NIA Phase II trial (Alzheimer's disease), Baltimore, MD, 2010-Present
- Statistical Consultant, Alper Biotech, LLC, Rockville, MD, 2010-2011
- Statistical Consultant, BioMarker Strategies Company, Baltimore, MD, 2010-2012
- Statistical Consultant, SNBL Clinical Pharmacol Center, Baltimore, MD, 2010-2012
- Member, DSM Board for NIH/NIA trial in Phase I study (Alzheimer's disease), Baltimore, MD, 2012-Present
- Member, NIH/NIA IRP Scientific Review Committee, 2012-Present
- Reviewer and Member of a Panel, SBIR/STTR applications, NIH/NIDCR, Bethesda, MD, 2015
- International Topical Expert (Biostatistics & Bioinformatics) and Voting Member. Innsbruck, Austria (Cancer Centre Site Visit, September 13-15), 2011
- Statistician on HYPNO Trial, International Atomic Energy Agency (IAEA), Vienna, Austria, 2014-Present
- International Expert in Biostatistics and Bioinformatics, Swiss National Science Foundation (SNSF), Berne, Switzerland, 2015