670 W. Baltimore Street, HSF III, 8th Floor
Education and Training
- University of Virginia, BA, Neurobiology, 1980-1984
- University of Virginia School of Medicine, MD, 1985-1989
- University of Pittsburgh, Resident, Emergency Medicine, 1989-1992
- Children’s Hospital, Boston, Fellow, Pediatric Emergency Medicine, 1992–1994
- Children’s Hospital, Boston, Resident, Pediatric Emergency Medicine, 1994–1996
- Children’s Hospital, Boston, Fellow, Pediatric Critical Care, 1996-1999
Allan Doctor, MD is Professor of Pediatrics at the University of Maryland School of Medicine, where he directs the Center for Blood Oxygen Transport and Hemostasis. He is a Pediatric Intensivist and previously led Pediatric Critical Care at Washington University and St Louis Children’s Hospital for 10 years, stepping down and then transitioning to UMB to focus on a rapidly expanding research program and on development of a novel bio-synthetic artificial red cell.
His laboratory studies the role of red blood cell-based signaling in the control of regional blood flow, related pathophysiology arising from acquired red cell injuries, blood substitute design, and on translational transfusion medicine in critical illness.
pediatric critical care medicine, pediatric emergency medicine, red blood cell-based signaling, blood substitute, resuscitation, nitric oxide, metabolomics, translational transfusion medicine
Doctor A, Platt R, Sheram ML, Eischeid A, McMahon T, Maxey T, Doherty J, Axelrod M, Kline J, Gurka M, Gow A and Gaston B. Hemoglobin conformation couples S-nitrosothiol content in erythrocytes to O2 gradients Proc Natl Acad Sci. 2005;102:5709-14. PMID:15824313
Rogers S, Said A, Corcuera D, Kanter J, McLaughlin D, Kell P, Doctor A. Hypoxia limits antioxidant capacity in red blood cells by altering glycolytic pathway dominance. FASEB J. 2009;23(9):3159-70. PMID:19417084
Rogers S, Ross J, Gibbons L, McLaughlin D, Hassan M, Griffin S, Neumayr T, DeBaun M and Doctor A. Sickle hemoglobin disturbs normal coupling between erythrocyte O2content, glycolysis and antioxidant capacity. Blood. 2013;121(9):1651-62. PMID: 23297128
Guilliams K, Fields M, Ragan D, Eldeniz C, Binkley M, Doctor A, Hulbert M, Shimony J, Vo K, McKinstry R, An H, Lee J and Ford A. Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell disease. Blood. 2018;131(9):1012-1021. PMID: 29255068.
Mistry N, Mazer J, Lazarus A, Cahill L, Solish M, Zhou Y, Romanova N, Hare A, Doctor A, Fisher J, Brunt K, Simpson J, and Hare G. Cardiovascular and Hypoxic Cellular Responses to Moderate Anemia Induced by a Red Blood Cell-Specific Antibody. Am J Physiol. 2018;314(4):R611-R622. PMID: 29351418
Spinella P, Sniecinski R, Trachtenberg F, Inglis H, Ranganathan G, Heitman J, Szlam F, Danesh A, Stone M, Keating S, Levy J, Assmann S, Steiner M, Doctor A, and Norris P. Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery. Transfusion. 2019;59(4):1209-1222.
Rogers SC, Moynihan FT 4th, McDonough R, Timm DD, Hovmand-Warner E, Frazier E, Thomas KA, Spinella PC, Doctor A. Effect of plasma processing and storage on microparticle abundance, nitric oxide scavenging, and vasoactivity. Transfusion. 2019;59(S2):1568-1577.
Doctor A. and Stamler JS. NO Transport in Blood: A third gas in the respiratory cycle. In: Comprehensive Physiology: Respiratory Physiology. Wagner P and Hlastala M, Ed’s. American Physiological Society. Compr Physiol1:541-568, 2011. PMID: 23737185
Said A, Rogers SC and Doctor A. Red Cell Physiology and Signaling Relevant to the Critical Care Setting. Curr Opin in Pediatrics. 2015. Jun;24(3):267-76. PMID: 25888155
Doctor A, Cholette J, Remy K, Carson J, Valentine S, Bateman S, Lacroix J. Recommendations on Red Blood Cell Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds from the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018.19(9S Suppl 1):S98-113. PMID: 30161064
- NIH/NIGMS Career Development Award
- ASCI/AAP Award, American Society of Clinical Investigation
- Best Doctors in America, Best Doctors in Saint Louis (each year since 2013)
- Winner, LEAP Entrepreneurship Competition, Washington University
- Gregory Mark Taubin Visiting Professor, Children’s National Medical Center
- Faculty Member of the Year, Skandalaris Ctr for Innovation
- 1999-2005: Associate Professor of Pediatrics & Anesthesia, Univ. of Virginia, Charlottesville, VA
- 2006-2014: Professor of Pediatrics & Biochemistry (with tenure), Washington Univ., St. Louis, MO
- 2006-2016: Director, Division of Pediatric Critical Care Medicine, Washington Univ., St. Louis
- 2014-2019: Professor of Pediatrics (with tenure), Washington University, St. Louis, MO