Skip to main content

James P. Barrett, PhD

Academic Title:

Research Associate

Primary Appointment:

Anesthesiology

Location:

Bressler Research Building 655 West Baltimore Street, Room 6-010 Baltimore, MD 21201

Phone (Primary):

410-706-5183

Fax:

410-706-1639

Education and Training

2006-2010: BA., Mod in Natural Science (Physiology) Trinity College Dublin, Ireland

2010-2014: PhD, Neuroscience, Trinity College Dublin, Ireland

2014-2017: Research Fellow, Shock, Trauma and Anestehsiology Research Center, University of Maryland School of Medicine 

2017-2019: Postdoctoral Fellow, Shock, Trauma and Anestehsiology Research Center, University of Maryland School of Medicine 

 

Highlighted Publications

Peer Reviewed Journal Articles

  1. Minogue AM, Barrett JP, Lynch MA. LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner. J Neuroinflammation. 9, 126. PMID: 22697788. 2012.
  2. Loane DJ, Stoica BA, Tchantchou F, Kumar A, Barrett JP, Akintola T, Xue F, Conn PJ, Faden AI. Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury. Neurotherapeutics. 11(4), 857-69. PMID: 25096154. 2014.
  3. Barrett JP, Minogue AM, Jones RS, Ribeiro C, Kelly RJ, Lynch MA. Bone marrow-derived macrophages from AβPP/PS1 mice are sensitized to the effects of inflammatory stimuli. J. Alzheimers Dis.. 44(3), 949-62. PMID: 25374107. 2015.
  4. Barrett JP, Costello DA, O'Sullivan J, Cowley TR, Lynch MA. Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli. J Neuroinflammation. 12, 67. PMID: 25890218. 2015.
  5. Barrett JP, Minogue AM, Falvey A, Lynch MA. Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages. Exp. Cell Res.. 335(2), 258-68. PMID: 26022664. 2015.
  6. Kumar A, Barrett JP, Alvarez-Croda DM, Stoica BA, Faden AI, Loane DJ. NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury. Brain Behav Immun. 58, 291-309. PMID: 27477920. 2016.
  7. Barrett JP, Henry RJ, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury. J Neuroinflammation. 14(65). PMID: 28340575. 2017.
  8. Srivastava S, Katorcha E, Makarava N, Barrett JP, Loane DJ, Baskakov IV. Inflammatory response microglia to prions is controlled by sialylation of PrPSc. Scientific Reports. PMID: 30054538. 2018.
  9. Ritzel RM, Doran SJ, Barrett JP, Henry RJ, Ma EL, Faden AI, Loane DJ. Chronic Alterations in Systemic Immune Function after Traumatic Brain Injury. J. Neurotrauma. 35(13), 1419-1436. PMID: 29421977. 2018.

Proffered Communications

  1. Barrett JP, Henry R, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ#. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for acute brain injury. National Capital Area TBI Research Symposium. Bethesda. MD. .
  2. Barrett JP, Minogue AM, Lynch MA#. Janus Kinase (JAK) plays a role in LPS-induced microglial activation. Cytokines in the brain: The good, the bad and the ugly. Dublin. Ireland. 2011.
  3. Barrett JP, Minogue AM, Lynch MA#. The role of JAK/STAT on the LPS-induced activation of microglia. Recent Advances in Multiple Sclerosis Block-MS Ireland. Dublin. Ireland. 2011.
  4. Barrett JP, Minogue AM, Lynch MA#. The role of JAK/STAT on the LPS-induced activation of microglia. Cost Action Inflammation in Brain Disease. Dublin. Ireland. 2011.
  5. Barrett JP, Lynch MA#, . Aging and the Inflammatory Response. School of Medicine Postgraduate Research Day. Dublin. Ireland. 2011.
  6. Barrett JP, Lynch MA#, . The Impact of Aging on Macrophage Activitation State and Function. School of Medicine Postgraduate Research Day. Dublin. Ireland. 2012.
  7. Barrett JP, Lynch MA#. The Impact of Aging on Macrophage Activation. British Neuroscience Association (BNA) Festival of Neuroscience. London. United Kingdom. 2013.
  8. Barrett JP, Henry R, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ#. NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for acute brain injury. Neurotrauma. Salt Lake City. UT. 2017.