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201-220 of 321 results by Haney Mallemat

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Title: What's the Diagnosis? Written by Zachary Dezman

Category: Visual Diagnosis

Posted: 12/3/2012 by Haney Mallemat, MD (Updated: 12/3/2012)

Question

11 year-old boy presents with right knee pain and swelling after falling off of his bicycle. What's the diagnosis?

Show Answer

Answer: Fracture of the intercondylar eminence of the tibia; Meyers & McKeever Grade II (grading system described below)

 

Intercondylar Eminence Fracture

  • Avulsion of the insertion of the ACL because the ligament stronger than incompletely ossified bone in children
  • Incidence is 3 in 100,000 children
  • Most common injury mechanism
    • Falls from a bicycle
    • Motor vehicle crash
  • Meyers and McKeever’s classification system
    • I (non-displaced) - Generally treated non-operatively with long-leg casting
    • II (hinged fragment)  - Generally treated like Grade I
    • III (displaced) - Requires surgical fixation

 

 

Reference: Tudisco, C., et al Intercondylar eminence avulsion fracture in children: long-term follow-up of 14 cases at the end of skeletal growth, J Pediatr Orthop B 19:403–408 c 2010

Show References

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Title: What's the diagnosis? Case by Dr. Jennifer Guyther

Category: Visual Diagnosis

Posted: 11/26/2012 by Haney Mallemat, MD (Updated: 11/26/2012)

Question

2 year-old male with past medical history of asthma presents with fever and respiratory distress. CXR is shown below. What’s the diagnosis? (Hint: ...look beyond the obvious)

Show Answer

Answer #1: Multifocal opacities predominantly in left lower lobe representing pneumonia 

Answer #2 Healing left-sided rib fractures involving the lateral aspects of ribs 8 through 10th suspicious for non-accidental trauma (see X-ray below)

 

Pediatric CXR pearls

  • Always remember to thoroughly examine x-rays to screen for abnormal findings.
  • Posterior rib fractures are highly suspicious for abuse in pediatric patients as the differential is very small beyond accidental trauma.
  • General risk factors increasing the risk for pediatric rib fractures:
    • Gestational age less than 30 weeks
    • Low-birth weight
    • Chronic lung disease
    • Chronic diuretic use
    • Prolonged parenteral nutrition

Bottom line: Screen patients for the above risk factors when rib fractures have been identified, but always think of abuse and the child’s safety first….and don’t forget to thoroughly examine radiology despite finding one abnormal finding.

Reference: Cosway et al.  Diagnostic indicators for NAI in children with rib fractures: A retrospective study.  Arch Dis Child 2011; 96 (supplement)

Show References

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Title: How Low, Should You Go?

Category: Critical Care

Posted: 11/20/2012 by Haney Mallemat, MD

A low-tidal volume (or protective) strategy of mechanical ventilation (i.e., tidal volume of 6-8cc/kg of ideal body weight) has previously been demonstrated to be beneficial in patients with acute respiratory distress syndrome (ARDS).

A meta-analysis was recently performed to determine whether this strategy of mechanical ventilation is also beneficial for patients without lung injury prior to initiation of mechanical ventilation.

Dr. Neto, et al. performed a meta-analysis of 20 studies (total of 2,822 mechanically ventilated patients) comparing a conventional ventilation strategy (average tidal volume was 10.6 cc/kg) to a protective ventilation strategy (average tidal volume was 6.4 cc/kg) of mechanical ventilation.

The authors concluded that patients ventilated with a protective lung-strategy had reductions in:

  • Mortality
  • Lung injury and ARDS
  • Atelectasis
  • Pulmonary infections          
  • Length of hospital stay

Bottom-line: This meta-analysis supports the notion that a strategy of low-tidal volume ventilation may have benefits for patients without ARDS, however prospective studies are needed.

Show References

Neto, S. et al. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome. JAMA, Oct. 24/31; 308;16.

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Title: The Vascular Probe Protector

Category: Visual Diagnosis

Posted: 11/19/2012 by Haney Mallemat, MD

Do you like placing ultrasound-guided IV catheters? Check out this trick for covering the probe during the procedure.

http://ultrarounds.com/Ultrarounds/The_Vascular_Probe_Protector.html

or

https://www.youtube.com/watch?v=ZuOq6Ea_FbA&feature=plcp

Show References

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Title: What's the Diagnosis? Case submitted by Dr. Michael Bond

Category: Visual Diagnosis

Posted: 11/12/2012 by Haney Mallemat, MD

Question

33 year-old male found unconscious by EMS and complains of right shoulder pain upon waking up in the ED. Diagnosis? 

Show Answer

Answer: Posterior shoulder dislocation

Show References

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Title: Too much salt may NOT be sweet.

Category: Critical Care

Posted: 11/6/2012 by Haney Mallemat, MD

Previous pearls have described the increasing evidence against colloid (e.g., hydroxyethyl starch) use during resuscitation. Now it appears that the crystalloid 0.9% normal saline (NS) may be under fire. 

The use of large volumes of NS has been associated with hyperchloremic metabolic acidosis and harm in animal studies. The risk of harm in humans, however, has been less clear. 

Bellomo et al. conducted a prospective observational study in which patients being resuscitated in the control group received NS at the clinicians' discretion; i.e., chloride-liberal strategy. The use of NS was restricted in the intervention group, where other less chloride containing fluids were used for resuscitation (e.g., Ringer's Lactate); i.e., a chloride-restrictive strategy. 

The authors found that when compared to patients in the chloride-liberal group, the chloride-restrictive group had significantly less rise in baseline creatinine, less overall AKI, and a reduced need for renal replacement therapy.

Bottom line: Although this was only an observational study, the liberal use of normal saline during resuscitation may increase the risk of AKI and renal replacement therapy. 

Show References

Bellomo, R. et al. Association between a chloride-liberal vs. chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012 Oct 17;308(15):1566-72. doi: 10.1001/jama.2012.13356.

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Title: What's the Diagnosis? Case by Dr. Ryan Spangler

Category: Visual Diagnosis

Posted: 11/5/2012 by Haney Mallemat, MD

Question

11 year-old male is tackled and falls on his outstretched hand while playing football. X-rays are shown below. What's the diagnosis?

 

 

Show Answer

Answer: Salter-Harris Fracture - Type II 

 

Salter-Harris Fracture (SHF)

SHF are fractures through the growth plate (a.k.a. the physis), therefore are unique to pediatric patients.

Fractures are categorized according to involvement of the physis, metaphysis, and epiphysis. Proper injury classification is important because it affects both the treatment and potential long-term complications. Radiographic findings can sometimes be subtle; especially Type 1 SHF.

Occult SHF should be suspected when there is tenderness or swelling over an epiphyseal surface with X-rays negative for fracture. In this case, children should be splinted and urgently followed up.

SHF classification

  • Type I: Disruption along growth plate (or physis) without bony fracture; may be occult 
  • Type II (most common): Separation through growth plate and fracture through metaphysis
  • Type III:  Intra-articular fracture of epiphysis into growth plate 
  • Type IV: Intra-articular fracture of epiphysis through entire growth plate and metaphysis
  • Type V: Crush injury of growth plate

Bonus Pearl:

Use mnemonic SALTR to remember fracture type (Type I-Slipped, II-Above physis, III-Lower physis, IV-Through physis, V-Rammed)

emedicine.medscape.com/article/412956-overview

Salter, R and Harris R.  Injuries involving the Epiphyseal Plate. Journal of Bone and Joint Surgery.  Vol 45-A. Issue 3, April 1963.

fpnotebook.com/_media/OrthoFractureSalterHarris.jpg

Show References

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Title: What's the Diagnosis?

Category: Visual Diagnosis

Posted: 10/29/2012 by Haney Mallemat, MD

Question

33 year-old male in respiratory distress. What's the diagnosis?

Show Answer

Answer: Click here or here

Show References

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Title: Sugar isn't always so sweet

Category: Critical Care

Posted: 10/24/2012 by Haney Mallemat, MD (Updated: 10/24/2012)

A study by Perner, et al recently published in NEJM observed that using hydroxyethyl starch (HES) as a resuscitation fluid increased mortality and renal replacement therapy at 90 days as compared to lactated acetate.
 
Another recent trial, called the “Crystalloid versus Hydroxyethyl Starch Trial” (CHEST) was a prospective randomized control trial from Australia comparing the use of 6% HES and 0.9% sodium chloride as a resuscitation fluid in the critically ill. 
 
With 7,000 patients enrolled (3,500 in each group), the CHEST trial is the largest single-trial of HES to date; the primary outcome was 90-day mortality and secondary outcomes were acute kidney injury (AKI) and renal-replacement therapy
 
The study concluded that there was no difference between groups for either morality or renal failure, but significantly more patients in the HES group required renal replacement therapy.
 
Bottom line: There is still no convincing data that patients receiving HES as part of their resuscitation have better outcomes compared to crystalloid (normal saline or lactated ringers) and there is increased harm with their use. Furthermore, the increased cost of HES does not appear to justify their routine use.

Show References

Perner A., et al. Hydroxyethyl Starch 130/0.4 versus Ringer's Acetate in Severe Sepsis. NEJM. 2012 Jun 27.

 
MyBurgh, J. Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care. N Engl J Med. 2012 Oct 17.
 
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Title: What's the Diagnosis? Image submitted by Dr. Ali Farzad

Category: Visual Diagnosis

Posted: 10/22/2012 by Haney Mallemat, MD

Question

Trauma patient (...yes, that's the only history you're given). Diagnosis?

Show Answer

Answer: Inverted left hemidiaphragm (or deep sulcus sign) secondary to a tension pneumothorax. There is also a superimposed hemothorax.

Show References

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Title: What's the Diagnosis?

Category: Visual Diagnosis

Posted: 10/15/2012 by Haney Mallemat, MD

Question

35 year-old male unrestrained driver following motor vehicle crash presents with blunt chest injury. There are multiple injuries on CXR (can you find them all?), but what's up with his right lung?

 

Show Answer

Answer: Pulmonary contusion 

Blunt chest trauma may result in pulmonary contusion, a parenchymal lung injury resulting in blood and edema within the alveolar spaces.

The pathophysiologic effects result in reduced lung compliance and gas exchange (i.e., dead space ventilation and/or shunting), increased risk of ARDS, and increased pulmonary vascular resistance. The full pathophysiologic effects may take up to 48 hours to develop. Resolution usually occurs within 3-5 days.

Diagnosis is typically made on CXR, although early CXR may underestimate the severity of injury. CT scan is much more sensitive for diagnosis (see green arrows below).

Management is supportive and requires strict attention to oxygenation. Positive pressure ventilation is occasionally required for respiratory failure and is sometimes recommended prophylactically for elderly patients, because their pulmonary status can rapidly decline secondary to their reduced lung reserve.

Aggressive control of chest wall pain is also required. Pain reduces both the frequency and depth of respirations leading to atelectasis, a reduction in mucus clearance, and an increased risk of pneumonia. Analgesia should be administered systemically, by epidural, or by local nerve block at the level of injury.

Show References

Lively, M. Pulmonary contusion in a collegiate diver: a case report. J Med Case Rep. 2011 Aug 10;5:362.

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Title: What's the Diagnosis? Critical Care Edition

Category: Critical Care

Posted: 10/9/2012 by Haney Mallemat, MD

Question

70 year-old male recently treated for community-acquired pneumonia presents with bloody diarrhea, fever, and severe abdominal pain. Abdominal Xray is shown below. Diagnosis?  

Show Answer

Answer: Toxic Megacolon

Toxic megacolon (TM) is an acute colitis with segmental or total colonic dilation (>6cm) plus systemic toxicity.

Actual incidence is unknown, but it is believed that TM is rising because of increasing cases of Clostridium difficile and the aging population. 

The most common etiologies are ulcerative, chron, and pseudomembranous colitis, but other causes exist and can be categorized as:

  • Inflammatory (e.g., ulcerative colitis, Behcet's disease, etc.)
  • Infectious (e.g., Clostridium difficile, Salmonella, Shigella, CMV, etc.)
  • Ischemia  
  • Miscellaneous (chemotherapy, Kaposi sarcoma, etc.)

The diagnosis is made based on clinical evidence of colitis plus evidence of colonic dilation on abdominal XR (diameter > 6cm, loss of haustra, or free intraperitoneal air secondary to perforation) or CT scan (demonstrating dilation or perforation).

Treatment includes:

  • Aggressive fluid resuscitation and vasopressors/inotropes.
  • Broad-spectrum antibiotics
  • NPO, NG tube for bowel decompression, and avoiding medications reducing GI motility (e.g., narcotics)
  • Early surgical evaluation is required although definitive surgical care (including colectomy) may be delayed for up to 3 days while monitoring the response to conservative treatment.

Show References

Autenrieth, D et al. Toxic Megacolon Inflammatory Bowel Dis. 2011 Aug 29. 

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Title: What's the Diagnosis? Image by Dr. Jason Adler

Category: Visual Diagnosis

Posted: 10/8/2012 by Haney Mallemat, MD (Updated: 10/8/2012)

Question

26 year-old male from Indonesia presents with severe abdominal pain and weight loss for the past two months. He also states he found this "worm" in the toilet (see below) after a bowel movement. What is the medical treatment for this condition? 

Show Answer

Answer: Mebendazole or albendazole 

The image above shows an Ascaris Lumbricoides (AL), the most common intestinal roundworm infection in humans. It typically occurs in inhabitants of impoverished areas with poor sanitation. 

Humans acquire AL from ingesting eggs from infected food or soil. Eggs hatch into larvae within the small intestine and then migrate through the mucosa to vascular beds of the alveoli within the lung. Larvae then migrate up the respiratory tree and are swallowed into the GI tract where they mate and more eggs are laid, maturing here or migrating to other organs within the body. 

Most infections are asymptomatic, but signs and symptoms can range from nonspecific pulmonary (first two weeks secondary to larval migration into lungs) to severe (after six weeks secondary to the mechanical effects of high parasite load in the gut). Symptoms include: 

  • Dyspnea, cough, wheezing, fever, etc. (migration of larvae through the lungs)
  • Malnourishment, iron-deficiency anemia, weight loss, GI obstruction, etc. (mechanical effects of a large parasite load)

Treatment during early infection is challenging because AL is non-specific and difficult to diagnose; symptomatic and supportive care is required. When the diagnosis is made, medications such as mebendazole and albendazole can be used to eradicate AL directly within the gut. Situations where worms cause intestinal obstruction, require manual debulking using scopes (e.g., colonoscopy) or surgery.

Show References

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Title: A Safer Way to Suture?

Category: Visual Diagnosis

Posted: 10/2/2012 by Haney Mallemat, MD (Updated: 10/2/2012)

Do you place central-lines?

Do you suture your central-lines into place?

Do you ever get worried that you are going to stick yourself with that needle?

If you answered yes to any of these questions, then maybe this pearl is for you; click here

Show References

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Title: Does a cuff-leak mean anything?

Category: Critical Care

Posted: 9/25/2012 by Haney Mallemat, MD

Intubated patients may occasionally meet certain criteria for extubation while in the Emergency Department. Extubation is not without its risk, however, as up to 30% of patients have respiratory distress secondary to laryngeal and upper airway edema, with some patients requiring re-intubation.

Prior to extubation, Intensivists use a brief “cuff-leak” test (deflation of the endotracheal balloon to assess the presence or absence of an air-leak around the tube) to indirectly screen for the presence of upper airway edema and ultimately the risk of re-intubation. The cuff-leak test is performed by deflating the endotracheal balloon followed by one or more of the following maneuvers:

  • Using the ventilator to measure the difference between inspired and expired tidal volumes; if there is a difference in the measured volumes, then air is “leaking” around the endotracheal tube, implying minimal airway edema.
  • Auscultation for an air “leak” around the tube during mechanical ventilation; auscultation of a leak implies that air is passing around the tube and minimal airway edema is present.
  • Disconnecting the patient from the ventilator and occluding the endotracheal tube during spontaneous breathing; auscultation of a leak implies that there is air passing around the tube and minimal airway edema is present.

Ochoa et al. performed a systematic review to determine the accuracy of the “cuff-leak” test to predict upper airway edema prior to extubation. The authors concluded that a positive cuff-leak test (i.e., absence of an air-leak) indicates an elevated risk of upper airway obstruction and re-intubation. A negative cuff-leak test (i.e., presence of an air-leak), however, does not reliably exclude the presence of upper airway edema or the need for subsequent re-intubation.

Bottom line: No test prior to extubation reliably predicts the absence of upper airway edema. Patients extubated in the Emergency Department require close observation with airway equipment located nearby.

 

Show References

Ochoa, ME et al. Cuff-leak test for the diagnosis of upper airway obstruction in adults: A systematic review
and meta-analysis. Intensive Care Med (2009) 35:1171–1179

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Title: Quick trick for guide-wire disposal

Category: Visual Diagnosis

Posted: 9/24/2012 by Haney Mallemat, MD

Guide-wires can be challenging to dispose of after central-line insertion because they are difficult to keep on the field, hard to place in the sharps box, and can splash nearby observers.

Click here for this little guide-wire disposal trick.

Show References

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Title: What's the Diagnosis? Written by Zachary Dezman

Category: Visual Diagnosis

Posted: 9/17/2012 by Haney Mallemat, MD

Question

27 year-old woman with AIDS presents complaining of a painful, puritic, and papular rash. What's the diagnosis?

Show Answer

Answer: Herpes zoster ophthalmicus

Herpes Zoster Ophthalmicus

  • Zoster involving the ophthalmic branch (V1) of the trigeminal nerve
  • Concomitant nasal rash is called Hutchinson's sign and heralds involvement of the eye (specifically the cornea); the nasociliary nerve innervates both the nose and eye
  • Must perform a thorough evaluation of the eye including slit lamp and fluorescein
  • Consider admission if:
    • symptoms are severe 
    • 2 or more dermatomes are involved
    • patients are immunocomprosmised
  • ​Treatment is with ​acyclovir, valacyclovir, or famciclovir

Show References

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Title: Non-Cardiogenic Pulmonary Edema

Category: Critical Care

Posted: 9/11/2012 by Haney Mallemat, MD

Question

40 year-old male with severe uncontrolled hypertension presents with altered mental status (head CT below). The CXR is from the same patient. What's the connection?

Show Answer

Answer: Neurogenic pulmonary edema (NPE)

NPE is defined as acute pulmonary edema following central nervous system (CNS) insult; NPE has been recognized for over 100 years, but its incidence is underreported due to a lack objective clinical criteria. 

The pathophysiology of NPE is poorly understood but it is generally believed that both cardiogenic and non-cardiogenic pulmonary edema play a role. CXR (see above) demonstrates a pattern similar to acute respiratory distress syndrome (i.e., bilateral interstitial infiltrates). 

CNS insults that are abrupt, rapidly progressive, and increase intracranial pressure (e.g., subarachnoid hemorrhage, intraparenchymal hemorrhage, traumatic brain injury, subdural, etc.) have the highest risk for NPE. Neural injury leads to sympathetic activation, the release of catecholamines, and one or all of the following:

  • Direct myocardial injury and cardiac dysfunction
  • Increased systemic afterload causing left ventricular dysfunction
  • Increased pulmonary vascular permeability and leak 

Treatment of NPE includes:

  • Reversing and treating the underlying disorder
  • Supplemental oxygen with positive pressure ventilation as necessary
  • Low-tidal volume  ventilation (if mechanically ventilated) with appropriate PEEP
  • Cautious use of diuretics, as adequate intravascular volume is needed for cerebral perfusion
  • Specific pharmacologic measures (eg. alpha blockers) have been studied but their efficacy is unclear and are not recommended as symptoms typically resolve within 72 hours

Show References

Davidson, D. et al. Neurogenic pulmonary edema. Crit Care. 2012 Mar 20;16(2):212.

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Title: What's the diagnosis? Case submitted by Dr. Ali Farzad and Joseph Martinez.

Category: Visual Diagnosis

Posted: 9/10/2012 by Haney Mallemat, MD

Question

40 year-old male with severe uncontrolled hypertension presents with altered mental status. Head CT is shown here. Name three common anatomic locations generally seen for non-traumatic intracerebral hemorrhage. 

 

Show Answer

Answer: The most common anatomic sites for intra-cerebral hemorrhage are:

  1. Basal ganglia (40-50%)
  2. Intralobar (20-50%)
  3. Thalamus (10-15%)
  4. Pons (5-12%)
  5. Cerebellum (5-10%), 

...and, don't forget the most common causes of non-traumatic intra-cerebral hemorrhage: 

  • Systemic hypertension (essential, drug use, ecclampsia)
  • Rupture of arteriovenous malformation or aneurysm 
  • Arterial disease (e.g., cerebral amyloid angiopathy)
  • Congenital or acquired coagulopathy
  • CNS tumor with necrosis and hemorrhagic conversion

Show References

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Title: What's the Diagnosis? Case submitted by Dr. Ali Farzad

Category: Visual Diagnosis

Posted: 9/3/2012 by Haney Mallemat, MD

Question

32 year-old female presents with 5 days of fever, chills, and flank pain. She is hypotensive on presentation and urinalysis shows pyuria. Click here for the non-contrast CT scan. What's the diagnosis and what type of antibiotics should be started empirically?

Show Answer

Answer: Staghorn caliculi secondary to struvite stone. Broad-spectrum antibiotics to cover anaerobic bacteria should be initiated.

  • Staghorn caliculi are upper urinary stones involving both the renal pelvis and at least 2 calyces.
  • Any category of renal stone can form a staghorn calculi, but most are magnesium-ammonium-phosphate stones (i.e., struvite stones); struvite stones are typically associated with urinary tract infections secondary to urease-producing bacteria (e.g., Proteus species).
  • Struvite stones may result in several types of urinary tract infections; perinephric abscess, pyelonephritis, and in severe cases, sepsis.
  • Management includes:
    • Early broad-spectrum antibiotics covering both aerobic and anaerobic bacteria until culture and sensitivities are available
    • Complete removal of stone is necessary (e.g., extracorporeal-shockwave lithotripsy, surgery, etc.)
  • The CT shown here demonstrates a left kidney struvite stone with associated air (green arrows) suggesting an anaerobic infection.

Show References

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