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Paul M. Luethy, PhD

Academic Title:

Assistant Professor

Primary Appointment:


Secondary Appointment(s):

Medical and Research Technology

Administrative Title:

Associate Director, Clinical Microbiology Laboratory, UMMC Laboratories of Pathology



Phone (Primary):

(410) 328-3789


(410) 328-1120

Education and Training

BS: Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan (2006-2010)
Ph.D.: Molecular Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas (2010-2015)
Fellowship: Medical and Public Health Laboratory Microbiology, Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland (2015-2017)


Dr. Luethy is an Assistant Professor at the University of Maryland School of Medicine, Department of Pathology. He is also the Associate Director of the Clinical Microbiology and Virology Laboratories at the University of Maryland Medical Center. He completed a CPEP-accredited fellowship in Medical and Public Health Laboratory Microbiology at the National Institutes of Health Clinical Center and is a Diplomate of the American Board of Medical Microbiology with expertise in the diagnosis of infectious disease.

Dr. Luethy is the Program Director of the CPEP-accredited Medical and Public Health Microbiology Fellowship at the University of Maryland School of Medicine. In addition, he performs research evaluating current and novel infectious disease diagnostics for their utility in the clinical laboratory and for improving patient care. He also is interested in developing molecular tools, including Next Generation Sequencing (NGS), for use in the clinical laboratory.

Research/Clinical Keywords

Microbiology; Molecular diagnostics for infectious diseases; Next Generation Sequencing (NGS) of infectious diseases; Laboratory and hospital utility of clinical microbiology diagnostics

Highlighted Publications

Hauser N, Kim JJ, Luethy PM, Schmalzle SA, Bork JT. Multicenter retrospective cohort study of the clinical significance of Staphylococcus lugdunensis isolated from a single blood culture set. Diagn Microbiol Infect Dis. 2020. 99 (3): 115261. PMID: 33290922

Luethy PM and Johnson JK. The use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the identification of pathogens causing sepsis. The Journal of Applied Laboratory Medicine. 2019. 3 (4): 675-685. PMID: 31639735

Luethy PM and Zelazny AM. Rapid one-step extraction method for the identification of molds using MALDI-TOF MS. Diagn Microbiol Infect Dis. 2018. 91 (2): 130-135. PMID: 29454652

Luethy PM, Murphy SC, Seilie AM, Xie YL, Lau CY, Tisdale JF, Hsieh MM, Reinhardt JL, Lau AF, Fahle GA. Diagnostic challenges of prolonged post-treatment clearance of Plasmodium nucleic acids in a pre-transplant autosplenectomized patient with sickle cell disease. Malar J. 2018. 17 (1): 23. PMID: 29321025

Hesse SE, Luethy PM, Beigel JH, Zelazny AM. 2017. Penicillium citrinum: Opportunistic pathogen or idle bystander? A case analysis with demonstration of galactomannan cross-reactivity. Med Mycol Case Rep.17: 8-10. PMID: 28580236



Additional Publication Citations

Luethy PM, Huynh S, Ribardo DA, Winter SE, Parker CT, Hendrixson DR. 2017. Microbiota-derived short-chain fatty acids modulate expression of Campylobacter jejuni determinants required for commensalism and virulence. mBio 8: e00407-17. PMID: 28487428

Luethy PM,Huynh S, Parker CT, Hendrixson DR. Analysis of the Activity and Regulon of the Two-component Regulatory System Composed by Cjj1484 and Cjj1483 of Campylobacter jejuni. J Bacteriol. 2015. 197(9):1592-1605. PMID: 21257775

Zhang Y, Luethy PM, Zhou R, Kroos L. 2013. Residues in Conserved Loops of Intramembrane Metalloprotease SpoIVFB Interact with Residues near the Cleavage Site in Pro-σK. J Bacteriol. 195(21):4936-4946. PMID: 23995631

Lee JS, Son B, Viswanathan P, Luethy PM, Kroos L. 2011. Combinatorial regulation of fmgD by MrpC2 and FruA during Myxococcus xanthus development. J Bacteriol. 193(7):1681-1689. PMID: 25691530