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Libin Wang, BM, MM, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Medicine

Education and Training

Education

  • Bachelor of Medicine (equivalent M.D.) Department of Medicine, Tianjin Medical University, Tianjin, China, 1995.
  • Master of Medicine (equivalent M.S. ) Department of Medicine, Tianjin Medical University, Tianjin, China, 1995.
  • Ph.D. of Genetics, Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas, 2002.

Training

  • Cardiovascular Disease Fellowship: Johns Hopkins University, Baltimore, Maryland. 2016.
  • Internal Medicine Residency: University of Miami, Jackson Health System, Miami, Florida. 2012.
  • Postdoctoral Research Associate: Harvard Medical School, Department of Genetics and Brigham and Women’s Hospital, Howard Hughes Medical Institute, Boston, Massachusetts. 2009.

Biosketch

Dr. Libin Wang is an assistant professor of medicine in the Division of Cardiovascular Medicine at the University of Maryland, School of Medicine.  He finished premedical training at Nankai University and obtained medical degrees from Tianjin Medical University in China (Bachelor of Medicine, MD equivalent, and Master of Medicine, 1995).

He came to the United States in 1996 for graduate school and received PhD in genetics from Texas A&M University in 2002.  He subsequently conducted postdoctoral researches in cardiovascular disease genetics at Brigham and Women’s Hospital, Harvard Medical School and Howard Hughes Medical Institute (2009).  His passion about patient care had driven him to completed internal medicine residency at Jackson Memorial Hospital, University of Miami (2012) and cardiovascular disease fellowship at Johns Hopkins University (2016).  Dr. Wang joined the University of Maryland faculty in July 2016.

His clinical interests are in general cardiology, dilated cardiomyopathy, hypertrophic cardiomyopathy, and echocardiography.  His main research interest focuses on the genetics of cardiovascular diseases. Dr. Wang’s research has been published in New England Journal of MedicineNature GeneticsCell, Annals of Internal Medicine, and Journal of Clinical Investigation.  His work has been recognized with Thomas W. Smith Award at Harvard Medical School and Howard S. Silverman Award at Johns Hopkins University.  

Research/Clinical Keywords

general cardiology, dilated cardiomyopathy, hypertrophic cardiomyopathy, echocardiography, genetics of cardiovascular diseases

Highlighted Publications

Cainzos-Achirica M., Desai C.S., Wang L., Blaha M.J., Lopez-Jimenez F., Kopecky S.L., Blumenthal R.S., Martin S.S. (2015).  Pathways Forward in Cardiovascular Disease Prevention One and a Half Years After Publication of the 2013 ACC/AHA Cardiovascular Disease Prevention Guidelines.  Mayo Clin Proc. 90(9):1262-1271.

Costa, M.W., Guo, G., Wolstein, O., Vale, M., Castro, M.L., Wang, L., Otway, R., Riek, P., Cochrane, N., Furtado, M., Semsarian, C., Weintraub, R.G., Yeoh, T., Hayward, C., Keogh, A., Macdonald, P., Feneley, M., Graham, R.M., Seidman, J.G., Seidman, C.E., Rosenthal, N., Fatkin, D., Harvey, R.P. (2013).  Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.  Circ Cardiovasc Genet.  6(3):238-247.

Chrispin, J., Martin, S.S., Hasan, R.K., Joshi, P.H., Minder, C.M., McEvoy, J.W., Kohli, P., Johnson, A.E., Wang, L., Blaha, M.J., Blumenthal, R.S. (2013).  Landmark lipid-lowering trials in the primary prevention of cardiovascular disease.  Clin Cardiol. 36(9):516-523.

Herman, D.S., Lam, L., Taylor, M.R.G., Wang, L., Teekakirikul, P., Christodoulou, D., Conner, L., DePalma, S.R., McDonough, B., Sparks, E., Teodorescu, D.L., Cirino, A.L., Banner, N.R., Pennell, D.J., Graw, S., Merlo, M., Lenarda, A.D., Sinagra, G., Bos, J.M., Ackerman, M.J., Mitchell, R.N., Murry, C.E., Lakdawala, N.K., Ho, C.Y., Barton, P.J.R., Cook, S.A., Mestroni, L., Seidman, J.G., and Seidman, C.E.  (2012).  Truncations of Titin Causing Dilated Cardiomyopathy. N Engl J Med. 366(7): 619-628.

Norton, N., Li, D., Rieder, M.J., Siegfried, J.D., Rampersaud, E., Züchner, S., Mangos, S., Gonzalez-Quintana, J., Wang, L., McGee, S., Reiser, J., Martin, E., Nickerson, D.A., Hershberger, R.E. (2011).  Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy.  Am J Hum Genet. 88(3): 273-282. 

Alcalai, R., Wakimoto, H., Arad, M., Planer, D., Konno, T., Wang, L., Seidman, J.G., Seidman, C.E., and Berul, C.I.  (2011).  Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.  J Cardiovasc Electrophysiol. 22(3): 316-324. 

Konno, T., Chen, D., Wang, L., Wakimoto, H., Teekakirikul, P., Nayor, M., Kawana, M., Eminaga, S., Gorham, J.M., Pandya, K., Smithies, O., Naya, F.J., Olson, E.N., Seidman, J.G., Seidman, C.E. (2010). Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 107(42): 18097-18102.

Teekakirikul, P., Eminaga, S., Toka, O., Alcalai, R., Wang, L., Wakimoto, H., Nayor, M., Konno, T., Gorham, J.M., Wolf, C.M., Kim, J.B., Schmitt, J.P., Molkentin, J.D., Norris, R.A., Tager, A.M., Hoffman, S.R., Markwald, R.R., Seidman, C.E., Seidman, J.G. (2010).  Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-beta.  J. Clin Invest. 120(10): 3520-3529.

Wang, L., Seidman, J.G., and Seidman C. E. (2010).  Harnessing molecular genetics for diagnosis & management in hypertrophic cardiomyopathy.  Annals of Internal Medicine 152(8): 513-520.

Wang LB, Seidman JG, Seidman CE. (2009).  Using molecular genetics to guide the diagnosis and treatment of hypertrophic cardiomyopathy.  Zhonghua Xin Xue Guan Bing Za Zhi 37(12):1063-1068. Chinese.

Mobine, H.R., Baker, A.B., Wang, L., Wakimoto, H., Jacobsen, K.C., Seidman, C.E., Seidman, J.G., and Edelman, E.R. (2009).  Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of cell-secreted factors.  Circ Heart Fail 2(2): 121-128.

Wang, L., Sewell, W. F., Kim, S. D., Shin, J. T., MacRae, C. A., Zon, L. I., Seidman, J.G., and Seidman C. E. (2008).  Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish.  Development 135(20): 3425-3434.

Wolf, C. M., Wang, L., Alcalai, R., Pizard, A., Burgon, P. G., Ahmad, F., Sherwood, M. C., Branco, D. M., Wakimoto, H., Fishman, G. I., See, V., Stewart, C. L., Connor, D. A., Berul, C. I., Seidman, C. E., and Seidman, J. G. (2008).  Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. Journal of Molecular and Cellular Cardiology 44(2): 293-303.

Wang, L. *, Schönberger, J. *, Shin, J. T., Kim, S. D., Depreux F. F. S., Zhu, H., Zon, L., Kim, J. B., MacRae, C. A., Mungall, A. J., Seidman, C. E., and Seidman, J. G. (2005).  Mutation in the transcriptional co-activator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.  Nature Genetics 37(4): 418-422.  * These authors contributed equally to this work.

Karamysheva, Z., Wang, L., Shrode, T., Bednenko, J., Hurley, L. A., and Shippen, D. E. (2003).  Developmentally programmed gene elimination in Euplotes crassus facilitates a switch in the telomerase catalytic subunit.  Cell 113(5): 565-576.

Wang, L. Dean, S.R., and Shippen, D. E. (2002).  Oligomerization of the telomerase reverse transcriptase from Euplotes crassusNucleic Acids Research 30(18): 4032-4039.

Ray, S., Karamysheva, Z., Wang, L., Shippen, D. E., and Price, C. M. (2002).  Interactions between telomerase and primase physically link the telomere and chromosome replication machinery.  Molecular and Cellular Biology 22(16): 5859-5868.

Awards and Affiliations

  • Howard S. Silverman Award for Originality and Creativity in Medical Research, School of Medicine, Johns Hopkins University. 
  • Professionalism Award for Integrity and Altruism in the Practice of Internal Medicine, Department of Medicine, University of Miami. 
  • Thomas W. Smith Fellowship Award, Brigham and Women’s Hospital, Harvard Medical School. 
  • Regent’s Fellowship, Texas A&M University. 
  • Kechang Wang Scholarship, Nankai University, China. 

Links of Interest

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