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** Fosphenytoin (Cerebyx) is a pro-drug of Phenytoin (Dilantin).
** Differences between fosphenytoin and phenytoin are primarily due to fosphenytoin being more water soluble.
Fosphenytoin versus Phenytoin:
• Fosphenytoin > less risk for cardiac-related adverse effects (propylene glycol not required for solubilization)
• Fosphenytoin > lower risk of local skin and subcutaneous irritation during infusion
• Fosphenytoin > can be given intramuscularly
• Fosphenytoin > can be infused at a faster rate (20 mg/kg phenytoin equivalents (PE’s) load at a rate of 100 to 150 mg of PE’s/minute) due to its safer side/adverse effects profile.