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In this retrospective study of 4635 patients, continuing oral beta blocker within 48 hours of presentation for patients with sepsis was associated with a reduced risk of all-cause mortality within 90 days of hospital admission (hazard ratio 0.77; 95% CI, 0.61–0.98; p = 0.03), and a shorter hospital stay (incidence rate ratio 0.39; 95% CI, 0.38–0.41; p < 0.001).
Therefore, it is reasonable to consider Beta-blocker if patients are adequately resuscitated.
References
Christian-Miller N, Lee KT, Pashun R, Ballut K, Prescott H, Cascino T, Taylor SP, Ansari S, Sjoding MW, Nagle M, Admon AJ. Continuing vs. Withholding Home Beta-Blockers at Admission for Suspected Infection: A Target Trial Emulation. Crit Care Med. 2026 Sep 1;54(9):2350-2360. doi: 10.1097/CCM.0000000000007229. Epub 2026 Jun 9. PMID: 42262489