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This case report reminds us that vasculitis is an inflammatory process that attacks blood vessels leading to organ dysfunction. The etiology can be a hypersensitivity reaction (think drugs) or an IgA mediated process secondary to infection (Strep or Mycoplasma). In this case, concomitate use of NSAIDS (very common etiology of hypersensitivity) and Mycoplasma lead to vasculitis. Treatment ranges from supportive care, to steroids to immunosuppressive agents such as azathioprine.
References
Elaine Yu, Akousa Osei-Tutu, Rachna Subramony,
Small Vessel Vasculitis from Mycoplasma Infection and Concurrent Topical Nonsteroidal Anti-Inflammatory Drug (NSAID) Medication,
The Journal of Emergency Medicine,
Volume 82,
2026,
Pages 88-93,
ISSN 0736-4679,
https://doi.org/10.1016/j.jemermed.2025.12.003.