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When compared to saline(!) trauma patients with a high injury severity score who received ketamine via pca for pain control had better quality of life indicators at 1,3, and 6 months post injury.
References
Trevino, C. , Carver, T. , Tomas, C. , Larson, C. , Mantz-Wichman, M. , Peppard, W. & deRoon-Cassini, T. (2026). Acute traumatic pain treatment with ketamine decreased PTSD and anxiety symptoms 6 months post hospital discharge. Journal of Trauma and Acute Care Surgery, 100 (2), 215-220. doi: 10.1097/TA.0000000000004835.