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These authors looked at survival to discharge pre and post-implementation of a single dose epinephrine protocol for out of hospital cardiac arrest as it relates to age ranges. They found that older patients had a survival rate of 12% in the single dose protocol compared to 6% in the multidose protocol. Younger and middle aged patients had no difference in survival pre and post-implementation. At least in older adults, epinephrine does not seem to offer much benefit when given more than one time during cardiac arrest.
References
Single Dose Epinephrine Protocol Is Associated With Improved Survival of Older Adults With Out-Of-Hospital Cardiac Arrest
Ethan J. Lilien, Nicklaus P. Ashburn, Tyler S. George, Anna C. Snavely, Bryan P. Beaver, Casey G. Costa, Michael A. Chado, Harris A. Cannon, James E. Winslow, R. Darrell Nelson … See all authors
First published: 25 September 2025 Academic Emergency Medicine
https://doi.org/10.1111/acem.70154