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Title: Frailty as troponin: an analogy

Category: Geriatrics

Keywords: frailty, geriatrics, troponin, syndrome (PubMed Search)

Posted: 8/27/2025 by Robert Flint, MD (Updated: 8/27/2025)

This editorial reminds us about the use of frailty measures in the geriatric population. 

The authors write that frailty “describes a state of vulnerability causing an impaired ability to maintain homeostasis due to reduced physiologic reserve. Frailty is associated with disability, multimorbidity, cognitive impairment, institutionalization, and mortality. **Analogous to troponin testing, frailty assessment has been used to risk stratify older adults.**”

They also remind us that frailty is a syndrome not a disease in and of itself. It impacts how disease affects the patient and should inform our care, but not generate ageism or therapeutic nihilism. 

Once frailty is identified, it allows for further assessment looking at the “Geriatric 5M's framework: Mind, Mobility, Medications, Multicomplexity, and Matters Most.”

References

Is Frailty the Geriatric Troponin? 

Jacqueline M. McMillan, Julian Falutz Journal of the American Geriatrics Society

First published: 12 March 2025 https://doi.org/10.1111/jgs.19423


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