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The use of seizure prophylaxes in moderate to severe head injury has been recommended for 7 days post-injury. In general, levetiracetam is used for seizure prophylaxes in this group of patients. This study looked retrospectively at high (over 500 mg BID) vs. low (500 mg bid) dosing and found there was no difference in seizure events in either group. Overall 6% of patients had a seizure in this seven day window even with medication given.
References
Mann A, Livers K, Frick CD, et al. Evaluation of levetiracetam dosing for seizure prophylaxis in traumatic brain injury. Trauma. 2024;0(0). doi:10.1177/14604086241230598