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Free Biostatistics Software Options
EpiCalc 2000 – available for Windows. Capabilities include sample size calculation, inferential statistics (p values, 95% CI), simple stratified analysis, paired and independent analyses. Right clicking allows you to do many things. (http://www.brixtonhealth.com/epicalc.html). I've had the most experience with this one.
Epi Info – supported by CDC. Available for Windows and for hand-held. (https://www.cdc.gov/epiinfo/index.html)
P/S – Power and Sample Size Calculation – available for Mac and Window. Supported by Vanderbilt biostatistics. (https://biostat.app.vumc.org/wiki/Main/PowerSampleSize)
References
Epicalc: http://www.brixtonhealth.com/epicalc.html
Epi Info: https://www.cdc.gov/epiinfo/index.html
P/S: https://biostat.app.vumc.org/wiki/Main/PowerSampleSize