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Building on Dr. Winter's pearl from a couple of weeks ago, this is more evidence that a one-size-fits-all approach to fluid volume for resuscitation in sepsis doesn't fit.
This update to a previous systematic review and meta-analysis of 17 trials concluded that lower-volume IV fluid goals "probably result in little to no difference in all-cause mortality" or "little to no difference in serious adverse events" compared with higher IVF volumes.
Summary: This is yet another study suggesting that a lower fluid volume goal is probably better, or at least isn't harmful, but is not the pratice-changing paper everyone is looking for.
Happy Thanksgiving Everyone!
References
https://pubmed.ncbi.nlm.nih.gov/37142091/