Search
Patient
-
Single Center, double-blinded, randomized trial.
-
Patients with cancer and septic shock
Intervention
-
4% albumin + lactate ringer bolus in 10 minutes
-
180 patients
Comparison:
-
Lactate ringer bolus in 10 minutes
-
180 patients
Outcome:
-
Primary: Any mortality within 7 days of randomization.
-
Secondary: Mortality within 28 days, renal replacement therapy (RRT)
Results:
-
7-day mortality: 46 (25%) for LR + albumin vs. 40 (22%) for LR only
-
28-day mortality: 96 (53%) for LR + albumin vs. 83 (46%) for LR only
-
RRT: 16 (9%) for LR + albumin vs. 12 (7) for LR only
Conclusion:
Adding albumin for early resuscitation to crystalloids did not improve mortality in cancer patients with septic shock.
References
Lactated Ringer's Versus 4% Albumin on Lactated Ringer's in Early Sepsis Therapy in Cancer Patients: A Pilot Single-Center Randomized Trial.
Crit. Care Med. 2019 Oct;47(10):e798-e805.