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Title: Clinical Significance of Brain Atrophy

Category: Neurology

Keywords: brain atrophy, stroke, Alzheimer's Disease (PubMed Search)

Posted: 4/7/2010 by Aisha Liferidge, MD (Updated: 7/21/2026)

  • Nonspecific brain atrophy is a common finding on Head CT's, sometimes without any clearly articulated clinical significance for the emergency physician.
  • Generally speaking, brain atrophy is the manifestation of the effects of atherosclerosis.
  • Radiographically, it typically presents as widened sulci and dilated ventricles.
  • In patients with vague mental status abnormalities and limited access to medical history, consider the following brain atrophy clues in your management:

              --  Multiple areas of local cortical brain atrophy (wedge-shaped

                   appearance) suggests multi-infarct dementia.

              --  Disproportionate atrophy in the frontal and temporal lobes may be a 

                   sign of Alzheimer's Disease.


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