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Title: Heparin is out, LMWH is first-line for acute PE

Category: Pharmacology & Therapeutics

Keywords: Pulmonary embolism, heparin, low-molecular-weight heparin, LMWH (PubMed Search)

Posted: 3/12/2026 by Ashley Martinelli (Updated: 7/21/2026)

The 2026 Acute Pulmonary Embolism Guidelines were recently released. They recommend low-molecular-weight heparin (LMWH) over heparin for hospitalized patients with acute PE who require initial parenteral therapy unless they are in Category E2 Acute PE Cardiopulmonary Failure (level 1B-R).

Top benefits include:

  • Reduce recurrent VTE
  • Reduce bleeding
  • More predictable response

References

2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | Circulation


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