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Of 925 ED headache patients in this meta analysis comparing extrapyramidal side effects of bolus vs. continuous infusion of metoclopremide the majority of the reactions occurred in the bolus group.
References
Ryuta Onodera, Yusuke Ito, Takahiro Itaya, Yoshie Yamada, Taku Iwami, Yusuke Ogawa,
Extrapyramidal symptoms and effectiveness of continuous vs bolus intravenous metoclopramide: A systematic review and meta-analysis,
The American Journal of Emergency Medicine,
Volume 103,
2026,
Pages 36-44,
ISSN 0735-6757,
https://doi.org/10.1016/j.ajem.2026.01.051.