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Currently Approved LMWHs for the Treatment of Acute PE:
- Enoxaparin-1 mg/kg every 12 hours subcut
- Tinzaparin 175 Units/kg once daily subcut
- The pentasaccharide: Fondaparinux- at a dose of 5 mg for body weight <50 kg, 7.5 mg for 50-100 kg, and 10 mg for >100 kg, once daily
Make sure to monitor platelet counts regardless of agent chosen.
References
Konstantinides. Acute pulmonary embolism revisited. Heart. June 2008