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This large retrospective database study compared those receiving antibiotics after anterior nasal packing to those that did not. There was no difference in clinically significant infection between the groups leading the authors to conclude prophylactic antibiotics after anterior nasal packing is not required.
References
Tran QK, Vashee I, Vanga R, Camp S, Rallo MK, Najafali D, Bontempo LJ, Pourmand A. Is antibiotic prophylaxis necessary for anterior epistaxis with packing? Insights from a large database. Am J Emerg Med. 2025 Mar 19;93:64-72. doi: 10.1016/j.ajem.2025.03.040. Epub ahead of print. PMID: 40147155.