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- Therapeutic concentration considered 10-20 mg/dL
- Some hospitals report in "mg/L" thus a level of 110 mg/L is therapeutic
- Symptoms of Toxicity usually > 40 mg/dL
- Consider Hemodialysis in any patient with a serum concentration >100 mg/dL
First Line Therapy: Urine Alkalinization (pH >7.5) by administrating NaHCO3
Other Indications for Hemodialysis in Salicylate Poisoned Patient:
- Renal Failure
- CHF
- Acute Lung Injury
- Persistent CNS disturbances
- Refractory metabolic acidosis or electrolyte abnormality
- Hepatic insufficiency with coagulopathy